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Review

A Bioinformatics Systems Biology Analysis of the Current Oral Proteomic Biomarkers and Implications for Diagnosis and Treatment of External Root Resorption

1
Department of Endodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA
2
Department of Emergency Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Alberto Spisni
Int. J. Mol. Sci. 2021, 22(6), 3181; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063181
Received: 1 March 2021 / Revised: 15 March 2021 / Accepted: 17 March 2021 / Published: 20 March 2021
(This article belongs to the Special Issue Human Saliva as a Source of Biomarkers for Oral Diseases)
External root resorption (ERR) is a silent destructive phenomenon detrimental to dental health. ERR may have multiple etiologies such as infection, inflammation, traumatic injuries, pressure, mechanical stimulations, neoplastic conditions, systemic disorders, or idiopathic causes. Often, if undiagnosed and untreated, ERR can lead to the loss of the tooth or multiple teeth. Traditionally, clinicians have relied on radiographs and cone beam computed tomography (CBCT) images for the diagnosis of ERR; however, these techniques are not often precise or definitive and may require exposure of patients to more ionizing radiation than necessary. To overcome these shortcomings, there is an immense need to develop non-invasive approaches such as biomarker screening methods for rapid and precise diagnosis for ERR. In this review, we performed a literature survey for potential salivary or gingival crevicular fluid (GCF) proteomic biomarkers associated with ERR and analyzed the potential pathways leading to ERR. To the best of our knowledge, this is the first proteomics biomarker survey that connects ERR to body biofluids which represents a novel approach to diagnose and even monitor treatment progress for ERR. View Full-Text
Keywords: external root resorption; invasive cervical resorption; dentin sialoprotein; dentin phosphoproteins; dentin sialophosphoprotein; dentin matrix acidic phosphoprotein 1; dental trauma and biomarkers external root resorption; invasive cervical resorption; dentin sialoprotein; dentin phosphoproteins; dentin sialophosphoprotein; dentin matrix acidic phosphoprotein 1; dental trauma and biomarkers
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MDPI and ACS Style

Mona, M.; Abbasi, Z.; Kobeissy, F.; Chahbandar, A.; Pileggi, R. A Bioinformatics Systems Biology Analysis of the Current Oral Proteomic Biomarkers and Implications for Diagnosis and Treatment of External Root Resorption. Int. J. Mol. Sci. 2021, 22, 3181. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063181

AMA Style

Mona M, Abbasi Z, Kobeissy F, Chahbandar A, Pileggi R. A Bioinformatics Systems Biology Analysis of the Current Oral Proteomic Biomarkers and Implications for Diagnosis and Treatment of External Root Resorption. International Journal of Molecular Sciences. 2021; 22(6):3181. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063181

Chicago/Turabian Style

Mona, Mahmoud, Zunnaira Abbasi, Firas Kobeissy, Abdulrahman Chahbandar, and Roberta Pileggi. 2021. "A Bioinformatics Systems Biology Analysis of the Current Oral Proteomic Biomarkers and Implications for Diagnosis and Treatment of External Root Resorption" International Journal of Molecular Sciences 22, no. 6: 3181. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22063181

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