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Review

Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction

Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
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Academic Editor: Micheline Misrahi
Int. J. Mol. Sci. 2021, 22(7), 3312; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073312
Received: 9 February 2021 / Revised: 9 March 2021 / Accepted: 20 March 2021 / Published: 24 March 2021
(This article belongs to the Special Issue Gonadotropin-Releasing Hormone Receptor Signaling and Functions 2.0)
The proper expression of gonadotropin-releasing hormone receptors (GnRHRs) by pituitary gonadotropes is critical for maintaining maximum reproductive capacity. GnRH receptor expression must be tightly regulated in order to maintain the normal pattern of expression through the estrous cycle in rodents, which is believed to be important for interpreting the finely tuned pulses of GnRH from the hypothalamus. Much work has shown that Gnrhr expression is heavily regulated at the level of transcription. However, researchers have also discovered that Gnrhr is regulated post-transcriptionally. This review will discuss how RNA-binding proteins and microRNAs may play critical roles in the regulation of GnRHR expression. We will also discuss how these post-transcriptional regulators may themselves be affected by metabolic cues, specifically with regards to the adipokine leptin. All together, we present evidence that Gnrhr is regulated post-transcriptionally, and that this concept must be further explored in order to fully understand the complex nature of this receptor. View Full-Text
Keywords: gonadotropin-releasing hormone receptor; post-transcriptional control; leptin gonadotropin-releasing hormone receptor; post-transcriptional control; leptin
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MDPI and ACS Style

Odle, A.K.; MacNicol, M.C.; Childs, G.V.; MacNicol, A.M. Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction. Int. J. Mol. Sci. 2021, 22, 3312. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073312

AMA Style

Odle AK, MacNicol MC, Childs GV, MacNicol AM. Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction. International Journal of Molecular Sciences. 2021; 22(7):3312. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073312

Chicago/Turabian Style

Odle, Angela K., Melanie C. MacNicol, Gwen V. Childs, and Angus M. MacNicol. 2021. "Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction" International Journal of Molecular Sciences 22, no. 7: 3312. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073312

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