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Peer-Review Record

Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure

Int. J. Mol. Sci. 2021, 22(7), 3321;
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2021, 22(7), 3321;
Received: 1 March 2021 / Revised: 22 March 2021 / Accepted: 22 March 2021 / Published: 24 March 2021
(This article belongs to the Special Issue Metabolic Therapies for Heart Failure)

Round 1

Reviewer 1 Report

Review is focused on an actual and important topic. I have some questions and comments:

1. In Table 1 are presented suggested daily doses of nutraceuticals for prevention and control of VH/HF. I assume that the presented doses represent summary of data obtained in several studies. The corresponding references for presented data should be included into the Table.


Minor comments:

In review you mentioned several times Nrf2. The abbreviation and function of this protein could be explained more in detail.

Please correct nrf2 to Nrf2.

Check in text the formula of Hydrogen sulfide – sometimes is H2S and not H2S.

Author Response

As requested, I have added citations to each of the cited nutraceuticals in Table 1 to provide the reader with insight regarding the basis of the dose ranges I suggest.

I have added text to page 4 (highlighted in yellow) which explains the meaning and function of Nrf2.  I have also corrected the mentions of Nrf2 and H2S throughout the manuscripts.  

Many thanks for your careful attention to this lengthy submission. 



Reviewer 2 Report

The review  article "Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure" summarized the existing evidence on the effects of nutraceuticals, diet and lifestyle on left ventricular hypertrophy and heart failure

The paper is well organized and written

Minor points

1) Please add a research strategy of the studies selected for the review 

2) Table 2 should be modified as follow 

 Nutrauceticals for VH/HF prevention  .. .. .. Nutrauceticals for VH/HF "treatment"  .. .. ..

Author Response

At the end of the abstract, I have added a sentence (highlighted in yellow) that explains my use of PubMed as the source of the research papers whose findings I cite.

I have revised the titles on Table 2 as suggested. 

Many thanks for making the effort to review this lengthy manuscript. 


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