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EVs from BALF—Mediators of Inflammation and Potential Biomarkers in Lung Diseases

1
Chair and Department of Biochemistry, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland
2
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Andreas Spittler
Int. J. Mol. Sci. 2021, 22(7), 3651; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073651
Received: 28 February 2021 / Revised: 26 March 2021 / Accepted: 27 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Extracellular Vesicles in Inflammation)
Extracellular vesicles (EVs) have been identified as key messengers of intracellular communication in health and disease, including the lung. EVs that can be found in bronchoalveolar lavage fluid (BALF) are released by multiple cells of the airways including bronchial epithelial cells, endothelial cells, alveolar macrophages, and other immune cells, and they have been shown to mediate proinflammatory signals in many inflammatory lung diseases. They transfer complex molecular cargo, including proteins, cytokines, lipids, and nucleic acids such as microRNA, between structural cells such as pulmonary epithelial cells and innate immune cells such as alveolar macrophages, shaping mutually their functions and affecting the alveolar microenvironment homeostasis. Here, we discuss this distinct molecular cargo of BALF-EVs in the context of inducing and propagating inflammatory responses in particular acute and chronic lung disorders. We present different identified cellular interactions in the inflammatory lung via EVs and their role in lung pathogenesis. We also summarize the latest studies on the potential use of BALF-EVs as diagnostic and prognostic biomarkers of lung diseases, especially of lung cancer. View Full-Text
Keywords: extracellular vesicles (EVs); bronchoalveolar lavage fluid (BALF); inflammatory lung diseases; lung cancer; exosomes; biomarker extracellular vesicles (EVs); bronchoalveolar lavage fluid (BALF); inflammatory lung diseases; lung cancer; exosomes; biomarker
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MDPI and ACS Style

Zareba, L.; Szymanski, J.; Homoncik, Z.; Czystowska-Kuzmicz, M. EVs from BALF—Mediators of Inflammation and Potential Biomarkers in Lung Diseases. Int. J. Mol. Sci. 2021, 22, 3651. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073651

AMA Style

Zareba L, Szymanski J, Homoncik Z, Czystowska-Kuzmicz M. EVs from BALF—Mediators of Inflammation and Potential Biomarkers in Lung Diseases. International Journal of Molecular Sciences. 2021; 22(7):3651. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073651

Chicago/Turabian Style

Zareba, Lukasz, Jacek Szymanski, Zuzanna Homoncik, and Malgorzata Czystowska-Kuzmicz. 2021. "EVs from BALF—Mediators of Inflammation and Potential Biomarkers in Lung Diseases" International Journal of Molecular Sciences 22, no. 7: 3651. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073651

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