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Article

Postnatal Catch-Up Growth Programs Telomere Dynamics and Glucose Intolerance in Low Birth Weight Mice

Departamento de Reproducción Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), 28040 Madrid, Spain
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Manfredi Rizzo, Anca Pantea Stoian and Ali Abbas Rizvi
Int. J. Mol. Sci. 2021, 22(7), 3657; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073657
Received: 12 March 2021 / Revised: 23 March 2021 / Accepted: 26 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Metabolic Syndrome: From Molecular Mechanisms to Novel Therapies)
Low birth weight and rapid postnatal weight gain are independent predictors of obesity and diabetes in adult life, yet the molecular events involved in this process remain unknown. In inbred and outbred mice, this study examines natural intrauterine growth restriction (IUGR) in relation to body weight, telomere length (TL), glucose tolerance, and growth factor gene (Igf1, Igf2, Insr, Igf1r, and Igf2r) mRNA expression levels in the brain, liver, and muscle at 2- and 10 days of age and then at 3- and 9 months of age. At birth, ~15% of the animals showed IUGR, but by 3 and 9 months, half of these animals had regained the same weight as controls without IUGR (recuperated group). At 10 days, there was no difference in TL between animals undergoing IUGR and controls. However, by 3 and 9 months of age, the recuperated animals had shorter TL than the control and IUGR-non recuperated animals and also showed glucose intolerance. Further, compared to controls, Igf1 and Igf2 growth factor mRNA expression was lower in Day 2-IUGR mice, while Igf2r and Insr mRNA expression was higher in D10-IUGR animals. Moreover, at 3 months of age, only in the recuperated group were brain and liver Igf1, Igf2, Insr, and Igf2r expression levels higher than in the control and IUGR-non-recuperated groups. These data indicate that catch-up growth but not IUGR per se affects TL and glucose tolerance, and suggest a role in this latter process of insulin/insulin-like growth signaling pathway gene expression during early development. View Full-Text
Keywords: fetal growth restriction; telomere shortening; sex; inbred; outbred fetal growth restriction; telomere shortening; sex; inbred; outbred
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MDPI and ACS Style

Pericuesta, E.; Gutiérrez-Arroyo, J.L.; Sánchez-Calabuig, M.J.; Gutiérrez-Adán, A. Postnatal Catch-Up Growth Programs Telomere Dynamics and Glucose Intolerance in Low Birth Weight Mice. Int. J. Mol. Sci. 2021, 22, 3657. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073657

AMA Style

Pericuesta E, Gutiérrez-Arroyo JL, Sánchez-Calabuig MJ, Gutiérrez-Adán A. Postnatal Catch-Up Growth Programs Telomere Dynamics and Glucose Intolerance in Low Birth Weight Mice. International Journal of Molecular Sciences. 2021; 22(7):3657. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073657

Chicago/Turabian Style

Pericuesta, Eva, Julia L. Gutiérrez-Arroyo, Maria J. Sánchez-Calabuig, and Alfonso Gutiérrez-Adán. 2021. "Postnatal Catch-Up Growth Programs Telomere Dynamics and Glucose Intolerance in Low Birth Weight Mice" International Journal of Molecular Sciences 22, no. 7: 3657. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073657

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