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Review

Pregnancy-Related Extracellular Vesicles Revisited

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Department of Obstetrics and Gynecology, Polizu Clinical Hospital, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania
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Alessandrescu-Rusescu National Institute for Mother and Child Health, Fetal Medicine Excellence Research Center, 020395 Bucharest, Romania
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Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Carol Davila University of Medicine and Pharmacy, 011171 Bucharest, Romania
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Division of Molecular Diagnostics and Biotechnology, Antisel RO SRL, 024095 Bucharest, Romania
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Department of Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania
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Division of Obstetrics, Gynecology and Neonatology, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania
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Department of Obstetrics and Gynecology, Polizu Clinical Hospital, Alessandrescu-Rusescu National Institute for Mother and Child Health, 020395 Bucharest, Romania
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Department of Surgical Oncology, Prof. Dr. Alexandru Trestioreanu Oncology Institute, Carol Davila University of Medicine and Pharmacy, 252 Fundeni Rd., 022328 Bucharest, Romania
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Authors to whom correspondence should be addressed.
Academic Editors: Paola Lanuti and Maurizio Muraca
Int. J. Mol. Sci. 2021, 22(8), 3904; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22083904
Received: 15 February 2021 / Revised: 20 March 2021 / Accepted: 7 April 2021 / Published: 9 April 2021
(This article belongs to the Special Issue Extracellular Vesicles as a New Source of Liquid Biopsy 2.0)
Extracellular vesicles (EVs) are small vesicles ranging from 20–200 nm to 10 μm in diameter that are discharged and taken in by many different types of cells. Depending on the nature and quantity of their content—which generally includes proteins, lipids as well as microRNAs (miRNAs), messenger-RNA (mRNA), and DNA—these particles can bring about functional modifications in the receiving cells. During pregnancy, placenta and/or fetal-derived EVs have recently been isolated, eliciting interest in discovering their clinical significance. To date, various studies have associated variations in the circulating levels of maternal and fetal EVs and their contents, with complications including gestational diabetes and preeclampsia, ultimately leading to adverse pregnancy outcomes. Furthermore, EVs have also been identified as messengers and important players in viral infections during pregnancy, as well as in various congenital malformations. Their presence can be detected in the maternal blood from the first trimester and their level increases towards term, thus acting as liquid biopsies that give invaluable insight into the status of the feto-placental unit. However, their exact roles in the metabolic and vascular adaptations associated with physiological and pathological pregnancy is still under investigation. Analyzing peer-reviewed journal articles available in online databases, the purpose of this review is to synthesize current knowledge regarding the utility of quantification of pregnancy related EVs in general and placental EVs in particular as non-invasive evidence of placental dysfunction and adverse pregnancy outcomes, and to develop the current understanding of these particles and their applicability in clinical practice. View Full-Text
Keywords: extracellular vesicles; placenta; gestation; pregnancy disorders; liquid biopsy extracellular vesicles; placenta; gestation; pregnancy disorders; liquid biopsy
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MDPI and ACS Style

Condrat, C.E.; Varlas, V.N.; Duică, F.; Antoniadis, P.; Danila, C.A.; Cretoiu, D.; Suciu, N.; Crețoiu, S.M.; Voinea, S.C. Pregnancy-Related Extracellular Vesicles Revisited. Int. J. Mol. Sci. 2021, 22, 3904. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22083904

AMA Style

Condrat CE, Varlas VN, Duică F, Antoniadis P, Danila CA, Cretoiu D, Suciu N, Crețoiu SM, Voinea SC. Pregnancy-Related Extracellular Vesicles Revisited. International Journal of Molecular Sciences. 2021; 22(8):3904. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22083904

Chicago/Turabian Style

Condrat, Carmen E., Valentin N. Varlas, Florentina Duică, Panagiotis Antoniadis, Cezara A. Danila, Dragos Cretoiu, Nicolae Suciu, Sanda M. Crețoiu, and Silviu C. Voinea 2021. "Pregnancy-Related Extracellular Vesicles Revisited" International Journal of Molecular Sciences 22, no. 8: 3904. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22083904

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