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Review

PET Molecular Imaging: A Holistic Review of Current Practice and Emerging Perspectives for Diagnosis, Therapeutic Evaluation and Prognosis in Clinical Oncology

1
Department of Biophysics and Nuclear Medicine-Molecular Imaging, Hôpitaux Universitaires Paris Saclay, Assistance Publique-Hôpitaux de Paris, CHU Bicêtre, 94270 Le Kremlin-Bicêtre, France
2
Service Hospitalier Frédéric Joliot-CEA, 91401 Orsay, France
3
Université Paris Saclay, CEA, CNRS, Inserm, BioMaps, 91401 Orsay, France
4
School of Medicine, Université Paris Saclay, 94720 Le Kremlin-Bicêtre, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Giorgio Treglia
Int. J. Mol. Sci. 2021, 22(8), 4159; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084159
Received: 3 April 2021 / Revised: 14 April 2021 / Accepted: 15 April 2021 / Published: 16 April 2021
PET/CT molecular imaging has been imposed in clinical oncological practice over the past 20 years, driven by its two well-grounded foundations: quantification and radiolabeled molecular probe vectorization. From basic visual interpretation to more sophisticated full kinetic modeling, PET technology provides a unique opportunity to characterize various biological processes with different levels of analysis. In clinical practice, many efforts have been made during the last two decades to standardize image analyses at the international level, but advanced metrics are still under use in practice. In parallel, the integration of PET imaging with radionuclide therapy, also known as radiolabeled theranostics, has paved the way towards highly sensitive radionuclide-based precision medicine, with major breakthroughs emerging in neuroendocrine tumors and prostate cancer. PET imaging of tumor immunity and beyond is also emerging, emphasizing the unique capabilities of PET molecular imaging to constantly adapt to emerging oncological challenges. However, these new horizons face the growing complexity of multidimensional data. In the era of precision medicine, statistical and computer sciences are currently revolutionizing image-based decision making, paving the way for more holistic cancer molecular imaging analyses at the whole-body level. View Full-Text
Keywords: PET; quantification; molecular imaging; theranostics; multimodality; computer science PET; quantification; molecular imaging; theranostics; multimodality; computer science
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MDPI and ACS Style

Duclos, V.; Iep, A.; Gomez, L.; Goldfarb, L.; Besson, F.L. PET Molecular Imaging: A Holistic Review of Current Practice and Emerging Perspectives for Diagnosis, Therapeutic Evaluation and Prognosis in Clinical Oncology. Int. J. Mol. Sci. 2021, 22, 4159. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084159

AMA Style

Duclos V, Iep A, Gomez L, Goldfarb L, Besson FL. PET Molecular Imaging: A Holistic Review of Current Practice and Emerging Perspectives for Diagnosis, Therapeutic Evaluation and Prognosis in Clinical Oncology. International Journal of Molecular Sciences. 2021; 22(8):4159. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084159

Chicago/Turabian Style

Duclos, Valentin, Alex Iep, Léa Gomez, Lucas Goldfarb, and Florent L. Besson 2021. "PET Molecular Imaging: A Holistic Review of Current Practice and Emerging Perspectives for Diagnosis, Therapeutic Evaluation and Prognosis in Clinical Oncology" International Journal of Molecular Sciences 22, no. 8: 4159. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084159

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