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Review

Preventive Aspects of Early Resveratrol Supplementation in Cardiovascular and Kidney Disease of Developmental Origins

1
Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
2
School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 811, Taiwan
4
Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
5
Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Manfredi Rizzo
Int. J. Mol. Sci. 2021, 22(8), 4210; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084210
Received: 7 March 2021 / Revised: 8 April 2021 / Accepted: 16 April 2021 / Published: 19 April 2021
(This article belongs to the Special Issue Health Benefits of Resveratrol 3.0)
The increase in the incidence of cardiovascular diseases (CVDs) and kidney disease has stimulated research for strategies that could prevent, rather than just treat, both interconnected disorders. Resveratrol, a polyphenolic compound with pleiotropic biofunctions, has shown health benefits. Emerging epidemiological data supports that early life environmental insults are regarded as increased risks of developing CVDs and kidney disease in adulthood. Conversely, both disorders could be reversed or postponed by shifting interventions from adulthood to earlier stage by so-called reprogramming. The purpose of this review is first to highlight current epidemiological studies linking cardiovascular and renal programming to resulting CVD and kidney disease of developmental origins. This will be followed by a summary of how resveratrol could exert a positive influence on CVDs and kidney disease. This review also presents an overview of the evidence documenting resveratrol as a reprogramming agent to protect against CVD and kidney disease of developmental origins from animal studies and to outline the advances in understanding the underlying molecular mechanisms. Overall, this review reveals the need for future research to further clarify the reprogramming effects of resveratrol before clinical translation. View Full-Text
Keywords: resveratrol; oxidative stress; chronic kidney disease; cardiovascular disease; hypertension; developmental origins of health and disease (DOHaD); gut microbiota; nitric oxide resveratrol; oxidative stress; chronic kidney disease; cardiovascular disease; hypertension; developmental origins of health and disease (DOHaD); gut microbiota; nitric oxide
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MDPI and ACS Style

Hsu, C.-N.; Hou, C.-Y.; Tain, Y.-L. Preventive Aspects of Early Resveratrol Supplementation in Cardiovascular and Kidney Disease of Developmental Origins. Int. J. Mol. Sci. 2021, 22, 4210. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084210

AMA Style

Hsu C-N, Hou C-Y, Tain Y-L. Preventive Aspects of Early Resveratrol Supplementation in Cardiovascular and Kidney Disease of Developmental Origins. International Journal of Molecular Sciences. 2021; 22(8):4210. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084210

Chicago/Turabian Style

Hsu, Chien-Ning, Chih-Yao Hou, and You-Lin Tain. 2021. "Preventive Aspects of Early Resveratrol Supplementation in Cardiovascular and Kidney Disease of Developmental Origins" International Journal of Molecular Sciences 22, no. 8: 4210. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084210

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