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Review

Role of Adipose Tissue in Inflammatory Bowel Disease

1
Department of Pediatrics, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, 77900 Olomouc, Czech Republic
2
Department of Clinical Biochemistry, University Hospital Olomouc, 77900 Olomouc, Czech Republic
3
Third Department of Internal Medicine—Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, 77900 Olomouc, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Robert Bucki
Int. J. Mol. Sci. 2021, 22(8), 4226; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084226
Received: 7 March 2021 / Revised: 5 April 2021 / Accepted: 16 April 2021 / Published: 19 April 2021
Inflammatory bowel diseases (IBDs), chronic inflammatory disorders affecting the gastrointestinal tract, include Crohn’s disease and ulcerative colitis. There are increasing clinical and experimental data showing that obesity, especially visceral adiposity, plays a substantial role in the pathogenesis of IBD. Obesity seems to be an important risk factor also for IBD disease severity and clinical outcomes. Visceral adipose tissue is an active multifunctional metabolic organ involved in lipid storage and immunological and endocrine activity. Bowel inflammation penetrates the surrounding adipose tissue along the mesentery. Mesenteric fat serves as a barrier to inflammation and controls immune responses to the translocation of gut bacteria. At the same time, mesenteric adipose tissue may be the principal source of cytokines and adipokines responsible for inflammatory processes associated with IBD. This review is particularly focusing on the potential role of adipokines in IBD pathogenesis and their possible use as promising therapeutic targets. View Full-Text
Keywords: adipokines; visceral obesity; mesenteric fat; inflammatory bowel disease; microbiome adipokines; visceral obesity; mesenteric fat; inflammatory bowel disease; microbiome
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MDPI and ACS Style

Karaskova, E.; Velganova-Veghova, M.; Geryk, M.; Foltenova, H.; Kucerova, V.; Karasek, D. Role of Adipose Tissue in Inflammatory Bowel Disease. Int. J. Mol. Sci. 2021, 22, 4226. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084226

AMA Style

Karaskova E, Velganova-Veghova M, Geryk M, Foltenova H, Kucerova V, Karasek D. Role of Adipose Tissue in Inflammatory Bowel Disease. International Journal of Molecular Sciences. 2021; 22(8):4226. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084226

Chicago/Turabian Style

Karaskova, Eva, Maria Velganova-Veghova, Milos Geryk, Hana Foltenova, Veronika Kucerova, and David Karasek. 2021. "Role of Adipose Tissue in Inflammatory Bowel Disease" International Journal of Molecular Sciences 22, no. 8: 4226. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22084226

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