Next Article in Journal
Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARβ/δ
Next Article in Special Issue
Effects of Maternal Resveratrol Intake on the Metabolic Health of the Offspring
Previous Article in Journal
Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism
Previous Article in Special Issue
Preventive Aspects of Early Resveratrol Supplementation in Cardiovascular and Kidney Disease of Developmental Origins
Review

Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease

by 1,2,†,‡, 1,2,†,‡ and 1,2,*,†
1
Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada
2
Centre for Neuroscience, Brock University, St. Catharines, ON L2S 3A1, Canada
*
Author to whom correspondence should be addressed.
Current address: Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
These authors contributed equally to this work.
Academic Editor: Antonio L. Teixeira
Int. J. Mol. Sci. 2021, 22(9), 4628; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094628
Received: 31 March 2021 / Revised: 20 April 2021 / Accepted: 26 April 2021 / Published: 28 April 2021
(This article belongs to the Special Issue Health Benefits of Resveratrol 3.0)
Alzheimer’s disease (AD) has traditionally been discussed as a disease where serious cognitive decline is a result of Aβ-plaque accumulation, tau tangle formation, and neurodegeneration. Recently, it has been shown that metabolic dysregulation observed with insulin resistance and type-2 diabetes actively contributes to the progression of AD. One of the pathologies linking metabolic disease to AD is the release of inflammatory cytokines that contribute to the development of brain neuroinflammation and mitochondrial dysfunction, ultimately resulting in amyloid-beta peptide production and accumulation. Improving these metabolic impairments has been shown to be effective at reducing AD progression and improving cognitive function. The polyphenol resveratrol (RSV) improves peripheral metabolic disorders and may provide similar benefits centrally in the brain. RSV reduces inflammatory cytokine release, improves mitochondrial energetic function, and improves Aβ-peptide clearance by activating SIRT1 and AMPK. RSV has also been linked to improved cognitive function; however, the mechanisms of action are less defined. However, there is evidence to suggest that chronic RSV-driven AMPK activation may be detrimental to synaptic function and growth, which would directly impact cognition. This review will discuss the benefits and adverse effects of RSV on the brain, highlighting the major signaling pathways and some of the gaps surrounding the use of RSV as a treatment for AD. View Full-Text
Keywords: resveratrol; metabolic dysregulation; Alzheimer’s disease; neuroinflammation; SIRT1; AMPK; neuronal health; synaptic plasticity; PGC1-α resveratrol; metabolic dysregulation; Alzheimer’s disease; neuroinflammation; SIRT1; AMPK; neuronal health; synaptic plasticity; PGC1-α
Show Figures

Figure 1

MDPI and ACS Style

Yang, A.J.T.; Bagit, A.; MacPherson, R.E.K. Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease. Int. J. Mol. Sci. 2021, 22, 4628. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094628

AMA Style

Yang AJT, Bagit A, MacPherson REK. Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease. International Journal of Molecular Sciences. 2021; 22(9):4628. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094628

Chicago/Turabian Style

Yang, Alex J.T., Ahmed Bagit, and Rebecca E.K. MacPherson 2021. "Resveratrol, Metabolic Dysregulation, and Alzheimer’s Disease: Considerations for Neurogenerative Disease" International Journal of Molecular Sciences 22, no. 9: 4628. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094628

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop