Blood–Brain Barrier and Neurovascular Unit In Vitro Models for Studying Mitochondria-Driven Molecular Mechanisms of Neurodegeneration
Abstract
:1. Introduction
2. Mitochondrial Dysfunction and NVU/BBB Impairment in Alzheimer’s Type Neurodegeneration
2.1. Aberrant Mitochondrial Function and Dynamics in Neurons
2.2. Dysfunctional Mitochondria in Astroglial Cells
2.3. Mitochondrial Dynamics and Metabolic Control in BMECs and Pericytes
3. Application of In Vitro NVU/BBB Models for Studying Mitochondria-Related Changes in Cell Metabolism: Current Trends and Challenges
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Salmina, A.B.; Kharitonova, E.V.; Gorina, Y.V.; Teplyashina, E.A.; Malinovskaya, N.A.; Khilazheva, E.D.; Mosyagina, A.I.; Morgun, A.V.; Shuvaev, A.N.; Salmin, V.V.; et al. Blood–Brain Barrier and Neurovascular Unit In Vitro Models for Studying Mitochondria-Driven Molecular Mechanisms of Neurodegeneration. Int. J. Mol. Sci. 2021, 22, 4661. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094661
Salmina AB, Kharitonova EV, Gorina YV, Teplyashina EA, Malinovskaya NA, Khilazheva ED, Mosyagina AI, Morgun AV, Shuvaev AN, Salmin VV, et al. Blood–Brain Barrier and Neurovascular Unit In Vitro Models for Studying Mitochondria-Driven Molecular Mechanisms of Neurodegeneration. International Journal of Molecular Sciences. 2021; 22(9):4661. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094661
Chicago/Turabian StyleSalmina, Alla B., Ekaterina V. Kharitonova, Yana V. Gorina, Elena A. Teplyashina, Natalia A. Malinovskaya, Elena D. Khilazheva, Angelina I. Mosyagina, Andrey V. Morgun, Anton N. Shuvaev, Vladimir V. Salmin, and et al. 2021. "Blood–Brain Barrier and Neurovascular Unit In Vitro Models for Studying Mitochondria-Driven Molecular Mechanisms of Neurodegeneration" International Journal of Molecular Sciences 22, no. 9: 4661. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094661