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Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises

by 1, 1,2,3,4,5 and 1,2,5,6,*
1
Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan
2
Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
3
Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County 35053, Taiwan
4
Comprehensive Cancer Center, Department of Biochemistry and Molecular Medicine, University of California at Davis, Sacramento, CA 95817, USA
5
TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan
6
Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas Andl
Int. J. Mol. Sci. 2021, 22(9), 4903; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094903
Received: 28 March 2021 / Revised: 30 April 2021 / Accepted: 3 May 2021 / Published: 5 May 2021
(This article belongs to the Special Issue LncRNAs in Health and Disease)
Oral cancer is one of the leading malignant tumors worldwide. Despite the advent of multidisciplinary approaches, the overall prognosis of patients with oral cancer is poor, mainly due to late diagnosis. There is an urgent need to develop valid biomarkers for early detection and effective therapies. Long non-coding RNAs (lncRNAs) are recognized as key elements of gene regulation, with pivotal roles in various physiological and pathological processes, including cancer. Over the past few years, an exponentially growing number of lncRNAs have been identified and linked to tumorigenesis and prognosis outcomes in oral cancer, illustrating their emerging roles in oral cancer progression and the associated signaling pathways. Herein, we aim to summarize the most recent advances made concerning oral cancer-associated lncRNA, and their expression, involvement, and potential clinical impact, reported to date, with a specific focus on the lncRNA-mediated molecular regulation in oncogenic signaling cascades and oral malignant progression, while exploring their potential, and challenges, for clinical applications as biomarkers or therapeutic targets for oral cancer. View Full-Text
Keywords: oral cancer; long non-coding RNA; tumorigenesis; cancer progression; metastasis oral cancer; long non-coding RNA; tumorigenesis; cancer progression; metastasis
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MDPI and ACS Style

Lei, C.-S.; Kung, H.-J.; Shih, J.-W. Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises. Int. J. Mol. Sci. 2021, 22, 4903. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094903

AMA Style

Lei C-S, Kung H-J, Shih J-W. Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises. International Journal of Molecular Sciences. 2021; 22(9):4903. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094903

Chicago/Turabian Style

Lei, Cing-Syuan, Hsing-Jien Kung, and Jing-Wen Shih. 2021. "Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises" International Journal of Molecular Sciences 22, no. 9: 4903. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094903

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