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Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13288 Marseille, France
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Academic Editor: Marco Falasca
Int. J. Mol. Sci. 2021, 22(9), 4970; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094970
Received: 8 April 2021 / Revised: 4 May 2021 / Accepted: 5 May 2021 / Published: 7 May 2021
(This article belongs to the Special Issue Pancreatic Fibrosis in Inflammation and Cancer)
Pancreatic fibrosis is caused by the excessive deposits of extracellular matrix (ECM) and collagen fibers during repeated necrosis to repair damaged pancreatic tissue. Pancreatic fibrosis is frequently present in chronic pancreatitis (CP) and pancreatic cancer (PC). Clinically, pancreatic fibrosis is a pathological feature of pancreatitis and pancreatic cancer. However, many new studies have found that pancreatic fibrosis is involved in the transformation from pancreatitis to pancreatic cancer. Thus, the role of fibrosis in the crosstalk between pancreatitis and pancreatic cancer is critical and still elusive; therefore, it deserves more attention. Here, we review the development of pancreatic fibrosis in inflammation and cancer, and we discuss the therapeutic strategies for alleviating pancreatic fibrosis. We further propose that cellular stress response might be a key driver that links fibrosis to cancer initiation and progression. Therefore, targeting stress proteins, such as nuclear protein 1 (NUPR1), could be an interesting strategy for pancreatic fibrosis and PC treatment. View Full-Text
Keywords: pancreatic fibrosis; pancreatitis; pancreatic cancer; NUPR1 pancreatic fibrosis; pancreatitis; pancreatic cancer; NUPR1
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MDPI and ACS Style

Huang, C.; Iovanna, J.; Santofimia-Castaño, P. Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer. Int. J. Mol. Sci. 2021, 22, 4970. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094970

AMA Style

Huang C, Iovanna J, Santofimia-Castaño P. Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer. International Journal of Molecular Sciences. 2021; 22(9):4970. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094970

Chicago/Turabian Style

Huang, Can, Juan Iovanna, and Patricia Santofimia-Castaño. 2021. "Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer" International Journal of Molecular Sciences 22, no. 9: 4970. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094970

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