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Article

Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties

1
Laboratory for Experimental Hypertension, Institute for Medical Research, Department for Cardiovascular Research, University of Belgrade, National Institute of the Republic Serbia, 11000 Belgrade, Serbia
2
Department for Experimental Toxicology and Pharmacology, National Poison Control Centre, Military Medical Academy, 11000 Belgrade, Serbia
3
Medical Faculty of the Military Medical Academy, University of Defence, 11000 Belgrade, Serbia
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Department of Chemistry, Faculty of Science, University of Hradec Kralove, 500 30 Hradec Kralove, Czech Republic
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Institute of Pathology and Forensic Medicine, Military Medical Academy, 11000 Belgrade, Serbia
6
Institute for Medical Research, Department for Biomedical Engineering and Biophysics, University of Belgrade, National Institute of the Republic Serbia, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Academic Editor: Christophe Guignabert
Int. J. Mol. Sci. 2021, 22(9), 5006; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22095006
Received: 23 March 2021 / Revised: 28 April 2021 / Accepted: 28 April 2021 / Published: 8 May 2021
(This article belongs to the Special Issue Health Benefits of Resveratrol 3.0)
Hypertension is one of the most prevalent and powerful contributors of cardiovascular diseases. Malignant hypertension is a relatively rare but extremely severe form of hypertension accompanied with heart, brain, and renal impairment. Resveratrol, a recently described grape-derived, polyphenolic antioxidant molecule, has been proposed as an effective agent in the prevention of cardiovascular diseases. This study was designed to examine chronic resveratrol administration on blood pressure, oxidative stress, and inflammation, with special emphasis on cardiac structure and function in two models of experimental hypertension. The experiments were performed in spontaneously (SHRs) and malignantly hypertensive rats (MHRs). The chronic administration of resveratrol significantly decreased blood pressure in both spontaneously and malignant hypertensive animals. The resveratrol treatment ameliorated morphological changes in the heart tissue. The immunohistochemistry of the heart tissue after resveratrol treatment showed that both TGF-β and Bax were not present in the myocytes of SHRs and were present mainly in the myocytes of MHRs. Resveratrol suppressed lipid peroxidation and significantly improved oxidative status and release of NO. These results suggest that resveratrol prevents hypertrophic and apoptotic consequences induced by high blood pressure with more pronounced effects in malignant hypertension. View Full-Text
Keywords: resveratrol; spontaneously and malignant hypertension; heart resveratrol; spontaneously and malignant hypertension; heart
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MDPI and ACS Style

Grujić-Milanović, J.; Jaćević, V.; Miloradović, Z.; Jovović, D.; Milosavljević, I.; Milanović, S.D.; Mihailović-Stanojević, N. Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties. Int. J. Mol. Sci. 2021, 22, 5006. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22095006

AMA Style

Grujić-Milanović J, Jaćević V, Miloradović Z, Jovović D, Milosavljević I, Milanović SD, Mihailović-Stanojević N. Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties. International Journal of Molecular Sciences. 2021; 22(9):5006. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22095006

Chicago/Turabian Style

Grujić-Milanović, Jelica, Vesna Jaćević, Zoran Miloradović, Djurdjica Jovović, Ivica Milosavljević, Sladjan D. Milanović, and Nevena Mihailović-Stanojević. 2021. "Resveratrol Protects Cardiac Tissue in Experimental Malignant Hypertension Due to Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Properties" International Journal of Molecular Sciences 22, no. 9: 5006. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22095006

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