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Reprogramming of Plant Central Metabolism in Response to Abiotic Stresses: A Metabolomics View
Review

Advances in Plant Metabolomics and Its Applications in Stress and Single-Cell Biology

1
Department of Biological Sciences, Florida A & M University, Tallahassee, FL 32307, USA
2
Department of Biology, University of Florida, Gainesville, FL 32611, USA
3
University of Florida Genetics Institute (UFGI), University of Florida, Gainesville, FL 32610, USA
4
Plant Molecular and Cellular Biology Program, University of Florida, Gainesville, FL 32610, USA
5
Proteomics and Mass Spectrometry, Interdisciplinary Center for Biotechnology Research (ICBR), University of Florida, Gainesville, FL 32610, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Manish Kumar Patel and Lam-Son Phan Tran
Int. J. Mol. Sci. 2022, 23(13), 6985; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23136985
Received: 26 April 2022 / Revised: 19 June 2022 / Accepted: 19 June 2022 / Published: 23 June 2022
In the past two decades, the post-genomic era envisaged high-throughput technologies, resulting in more species with available genome sequences. In-depth multi-omics approaches have evolved to integrate cellular processes at various levels into a systems biology knowledge base. Metabolomics plays a crucial role in molecular networking to bridge the gaps between genotypes and phenotypes. However, the greater complexity of metabolites with diverse chemical and physical properties has limited the advances in plant metabolomics. For several years, applications of liquid/gas chromatography (LC/GC)-mass spectrometry (MS) and nuclear magnetic resonance (NMR) have been constantly developed. Recently, ion mobility spectrometry (IMS)-MS has shown utility in resolving isomeric and isobaric metabolites. Both MS and NMR combined metabolomics significantly increased the identification and quantification of metabolites in an untargeted and targeted manner. Thus, hyphenated metabolomics tools will narrow the gap between the number of metabolite features and the identified metabolites. Metabolites change in response to environmental conditions, including biotic and abiotic stress factors. The spatial distribution of metabolites across different organs, tissues, cells and cellular compartments is a trending research area in metabolomics. Herein, we review recent technological advancements in metabolomics and their applications in understanding plant stress biology and different levels of spatial organization. In addition, we discuss the opportunities and challenges in multiple stress interactions, multi-omics, and single-cell metabolomics. View Full-Text
Keywords: metabolomics technologies; abiotic and biotic stresses; multi-omics; single-cell metabolomics; spatial metabolomics metabolomics technologies; abiotic and biotic stresses; multi-omics; single-cell metabolomics; spatial metabolomics
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MDPI and ACS Style

Katam, R.; Lin, C.; Grant, K.; Katam, C.S.; Chen, S. Advances in Plant Metabolomics and Its Applications in Stress and Single-Cell Biology. Int. J. Mol. Sci. 2022, 23, 6985. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23136985

AMA Style

Katam R, Lin C, Grant K, Katam CS, Chen S. Advances in Plant Metabolomics and Its Applications in Stress and Single-Cell Biology. International Journal of Molecular Sciences. 2022; 23(13):6985. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23136985

Chicago/Turabian Style

Katam, Ramesh, Chuwei Lin, Kirstie Grant, Chaquayla S. Katam, and Sixue Chen. 2022. "Advances in Plant Metabolomics and Its Applications in Stress and Single-Cell Biology" International Journal of Molecular Sciences 23, no. 13: 6985. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23136985

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