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Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors

Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India
Dabur Research Foundation, 22 Site IV, Sahibabad, Ghaziabad - 201010 U.P, India
Department of Biotechnology, Faculty of Science, Jamia Hamdard (Hamdard University), New Delhi - 110062, India
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2007, 8(9), 894-919;
Received: 2 May 2007 / Revised: 25 July 2007 / Accepted: 30 July 2007 / Published: 3 September 2007
(This article belongs to the Special Issue The Chemical Bond and Bonding)
Flavoprotein monoamine oxidase is located on the outer membrane ofmitochondria. It catalyzes oxidative deamination of monoamine neurotransmitters such asserotonin, norepinephrine and dopamine and hence is a target enzyme for antidepressantdrugs. MAO (mono amine oxidase) has two isoforms, namely MAO-A and MAO-B.MAO-A isoform has higher affinity for serotonin and norepinephrine, while; MAO-Bpreferentially deaminates phenylethylamine and benzylamine. These important propertiesdetermine the clinical importance of MAO inhibitors. Selective MAO-A inhibitors are usedin the treatment of neurological disorders such as depression. In this article we havedeveloped a Hypogen pharmacophore for a set of 64 coumarin analogs and tried to analyzethe intermolecular H-bonds with receptor structure. View Full-Text
Keywords: MAO-A; pharmacophore; docking MAO-A; pharmacophore; docking
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MDPI and ACS Style

Sairam, K.V.V.M.; Khar, R.K.; Mukherjee, R.; Jain, S.K. Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors. Int. J. Mol. Sci. 2007, 8, 894-919.

AMA Style

Sairam KVVM, Khar RK, Mukherjee R, Jain SK. Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors. International Journal of Molecular Sciences. 2007; 8(9):894-919.

Chicago/Turabian Style

Sairam, Kalapatapu V.V.M., Roop K. Khar, Rama Mukherjee, and Swatantra K. Jain 2007. "Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors" International Journal of Molecular Sciences 8, no. 9: 894-919.

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