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Review

Ancient Faunal History Revealed by Interdisciplinary Biomolecular Approaches

1
Department of Archaeology and Ancient History, Lund University, Helgonavägen 3, P.O. Box 192, 22100 Lund, Sweden
2
Centre for Palaeogenetics, Svante Arrhenius Väg 20C, 10691 Stockholm, Sweden
3
Molecular Biology Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babeș-Bolyai University, 400271 Cluj-Napoca, Romania
4
Doctoral School of Agricultural Engineering Sciences, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania
5
“Emil Racoviță” Institute of Speleology of the Romanian Academy, Calea 13 Septembrie, nr. 13, Sector 5, 050711 Bucharest, Romania
6
Department of Zoology, Stockholm University, 10691 Stockholm, Sweden
7
Department of Bioinformatics and Genetics, Swedish Museum of Natural History, 10405 Stockholm, Sweden
8
EPOC, UMR 5805, Université de Bordeaux, Allée Geoffroy St Hilaire, CEDEX, CS 50023 Pessac, France
9
Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babeș-Bolyai University, 400006 Cluj-Napoca, Romania
10
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden
11
Emil. G. Racoviță Institute, Babeș-Bolyai University, Clinicilor 5-7, 400006 Cluj-Napoca, Romania
*
Authors to whom correspondence should be addressed.
Submission received: 9 July 2021 / Revised: 3 August 2021 / Accepted: 5 August 2021 / Published: 10 August 2021

Abstract

:
Starting four decades ago, studies have examined the ecology and evolutionary dynamics of populations and species using short mitochondrial DNA fragments and stable isotopes. Through technological and analytical advances, the methods and biomolecules at our disposal have increased significantly to now include lipids, whole genomes, proteomes, and even epigenomes. At an unprecedented resolution, the study of ancient biomolecules has made it possible for us to disentangle the complex processes that shaped the ancient faunal diversity across millennia, with the potential to aid in implicating probable causes of species extinction and how humans impacted the genetics and ecology of wild and domestic species. However, even now, few studies explore interdisciplinary biomolecular approaches to reveal ancient faunal diversity dynamics in relation to environmental and anthropogenic impact. This review will approach how biomolecules have been implemented in a broad variety of topics and species, from the extinct Pleistocene megafauna to ancient wild and domestic stocks, as well as how their future use has the potential to offer an enhanced understanding of drivers of past faunal diversity on Earth.

1. Introduction

Animals have always been a part of and shaped human history. Additionally, people have played a crucial role in shaping the diversity and dynamics of animal populations, not least in modern times. Through competition for shared resources, early humans are considered to have had limited impact on fauna and its genetic diversity. However, in more recent history, human pressure has intensified, to the great benefit of some species (e.g., domesticates, commensals) and detriment of others (e.g., through habitat degradation and loss, decrease in diversity), leaving several species at risk of extinction.
Consequently, it is increasingly important for us to gain an understanding of the diversity and dynamics of the palaeofauna, some of which we only know from fossils and the artistic representations made by prehistoric humans millennia ago [1]. Although still methodologically challenging owing to the noise introduced by postmortem damage of the molecules, continuous advances in palaeomics and palaeoecology are making it possible for us to investigate increasingly more ancient faunal diversity (see [2,3]).
To date, a wide range of biomolecules, including proteins, nucleic acids, and lipids, preserved in fossils, artefacts, sediments, and other substrates, have been utilised [2,4,5,6]. Initial studies focused on reconstructing the palaeoecology and inferring the past diets of ancient fauna from isotopic signatures in bulk collagen (N(15N)/N(14N) that represents the ratio for nitrogen, abbreviated herein as δ15N, and on N(13C)/N(12C) that represents the ratio for carbon, abbreviated herein as δ13C), or the δ13C composition of bone apatite [7] and, in the last decade, the δ15N values of individual amino acids from collagen [8]. Simultaneously, in the 1980s, the first ancient DNA (aDNA) sequence fragment was successfully recovered from the extinct quagga (Equus quagga quagga) [9]. Roughly three decades later, the first complete high-quality genome of the woolly mammoth (Mammuthus primigenius) was sequenced [10]. In parallel with these developments, the analysis of collagen and non-collagenous proteins and proteomes extracted from ancient bones has developed at a rapid pace [11]. Lipids have been retrieved from frozen carcasses of Late Pleistocene mammoths, horses, and bison [12,13], as well as from ceramic vessels from the transition to agriculture, and have proven useful in determining patterns of animal food consumption by different populations [14,15]. Recently, the epigenetic memory (somatically heritable chemical modifications of the DNA that do not involve modifications of the sequence itself), which is plastic and responsive to the environment, has opened new avenues to the study of the regulatory changes underlying divergence, speciation, and extinction in ancient fauna [16,17,18]. RNA, a molecule until recently considered an improbable source of information for studying ancient fauna, has provided some first insights into the taxonomy and tissue-specific gene regulation of Late Pleistocene canids [19]. More recently, studies have begun to focus on palaeovirology as a means to elucidate the role of ancient viruses in ancient faunal evolutionary history (e.g., extinctions, island isolations, migrations), in addition to modern consequences on extant species [20,21].
These breakthroughs in ancient biomolecular research over the last decades are instrumental in opening up new perspectives on extinct and extant diversity and their deep-time population histories, ecology, and evolutionary patterns [22,23,24,25,26,27,28,29] not accessible through the analysis of modern molecules alone [30]. With ancient biomolecular research methods becoming increasingly available and powerful, in what ways would multiproxy approaches contribute to a more complete picture of past faunal diversity and evolutionary history?
The aim of this review is to explore the potential of integrated use of multi-biomolecular data identified by the authors for addressing complex questions related to ancient faunal diversity. Within a geochronological and palaeoclimatological context corresponding to the time period before and after the Pleistocene/Holocene transition (~11,700 years before present), estimated to roughly mark the point at which the size of the human population started to increase [31], we intend to consider some major evolutionary events in selected taxa reconstructed through biomolecular research. Ultimately, we will discuss the ways in which multiproxy biomolecular approaches may further our understanding of the evolution and extinction of some emblematic Pleistocene species on the one hand, and of the faunal transformations starting around the Pleistocene/Holocene transition on the other (the most profound being the domestication of a number of species).

2. Evolution and Extinction during the Pleistocene

During the Pleistocene period, from about 2.6 million to 11,700 years ago, the Earth’s climate went through cycles with extreme fluctuations between glacial and interglacial conditions. These climatic oscillations forced species to retreat into and expand from refugial areas, still visible in the genetic diversity and current distribution patterns of extant species [32,33,34]. At the end of the Pleistocene and beginning of the Holocene, the combined impact of these climatic fluctuations [35,36] and human expansion [35,37] disproportionately affected some large mammals, leading to their decline and final extinction (i.e., woolly mammoth, giant deer, woolly rhinoceros, and cave bear) [38]. Below, we will begin by describing two megafaunal species extensively studied from a biomolecular perspective: the cave bear (Ursus spelaeus sensu lato) and the woolly mammoth (Mammuthus primigenius) (Figure 1), from which abundant remains have been retrieved from circumstances particularly favourable for biological preservation, e.g., cave sediments and permafrost. These pioneering studies, ranging from method development to palaeoecology and population palaeogenomics, effectively laid the foundation for the field of research on biomolecules. Accordingly, these two species may be used as model systems for illustrating how the processes preceding extinction and the contribution to modern species’ genomes have been studied.
To further broaden the perspective on the impact of environmental changes on species’ diversity and evolution, additional representative Pleistocene taxa will be discussed: the woolly rhinoceros (Coelodonta antiquitatis), adapted to the cold of the last ice age, and the bison (Bison sp.), which managed not only to survive the other megafaunal species, but to thrive in their wake well into modern times.

2.1. Cave Bears

Cave bears are by far one of the most extensively studied extinct Pleistocene species [39]. They are closely related to the brown bear (Ursus arctos) and polar bear (Ursus maritimus), from which they diverged some 1.5 million years ago [40]. In contrast to its sister species, the brown bear, with whom cave bears coexisted sympatrically in Eurasia during the Pleistocene, the cave bear was not able to cope with changes in its environment and became extinct around 25,000 years ago [41].
From a biomolecular perspective, traditional isotopic methods based on δ15N and δ13C from bulk protein (collagen), and more recently δ15N analyses of individual amino acids, were used to reconstruct the cave bear’s dietary preferences. These studies essentially support a herbivorous diet across its range [41,42,43,44,45]. Palaeogenomic studies have revealed a complex evolutionary history within the cave bear species complex with three major groups: the Caucasian group including praekudarensis and kudarensis taxa; the European group including spelaeus, ingressus, eremus, and kanivetz from the Ural Mountains; and the Ural-specific group made up by rossicus [40].
Apart from focusing on cave bear palaeoecology and evolutionary history, studies based on isotopes and aDNA have also tried to answer one of the open-ended questions related to cave bear extinction: why did the cave bear go extinct, while the brown bear survived the unstable climate and human expansion in the Late Pleistocene? Consequently, comparative studies on sympatric and/or syntopic cave bear and brown bear populations have been conducted. Palaeodietary inferences showed an omnivorous diet for contemporaneous brown bears that might have played an important role in ensuring species survival, while an apparent lack of dietary flexibility might have made the cave bear vulnerable to decreases in plant biomass quantity and quality related to colder climates [43].
Comparative studies of population dynamics have mainly utilised mitochondrial markers. The first such study compared the demographic history of the extinct cave bear versus that of the extant brown bear, and revealed a constant population size in brown bears during the Late Pleistocene and a drastic decline in cave bears starting about 50,000 years ago [46]. Another study uncovered homing behaviour in cave bears from patterns of population structure contrasting greater spatial flexibility in brown bears [47], a difference in sociality between the two taxa that might have contributed to the extinction of cave bears.
Even though advances have been made in understanding cave bear’s palaeobiology and evolutionary history, the causes leading to cave bear extinction remain elusive. The debate is ongoing, with most studies suggesting human impact as the major factor based on an apparent absence of associated substantial climatic changes [39,48,49,50]. However, palaeoclimate records indicate harsh conditions contemporaneous to inferred evolutionary events that might have contributed to cave bear population decline that started approximately 50,000–40,000 years ago. For instance, the Heinrich 4 event and Campanian Ignimbrite volcanic eruption were two such major events that dramatically changed the landscape of Europe (Figure 2). Studies have shown that the Heinrich 4 event was exceptionally cold and dry [51]. Coupled with one of the most explosive eruptions in the Late Pleistocene, the Campanian Ignimbrite volcanic eruption, which affected large areas of Europe [52], it triggered catastrophic impacts on ecosystems (i.e., diminished food resources, fluoride poisoning), hypothesised to have affected large herbivores and other mammals, including Neanderthals [53,54]. Following the Heinrich 4 event, large areas of Europe experienced a climatic deterioration and progressive continentalization characterized by less precipitation, colder winters, and an open steppe ecosystem, lasting until about 27,000 years ago [55,56,57], possibly contributing to the loss of genetic diversity inferred in cave bear populations across Europe [39,49,58,59].
Few studies thus far have combined isotopes and aDNA to shed light on cave bear’s ecology, evolutionary history, and extinction [45,49,60,61] (Figure 3).

2.2. Woolly Mammoth

One of the most abundant and widespread herbivore species of the last glacial period was the woolly mammoth. They inhabited the productive and cold steppe-tundra that extended from western Europe through Asia into northern North America [62]. At the end of the Pleistocene, however, the woolly mammoth underwent a rapid population decline, and disappeared from most of its former range [63]. Two populations survived into the Holocene, isolated on two small islands: Wrangel Island in northeastern Siberia and St. Paul Island in Alaska [64,65], until the mammoth finally went extinct ca. 4000 years ago (Figure 2).
Both their iconic status and good preservation conditions in the northernmost parts of their distribution range have made woolly mammoths a popular subject for aDNA studies, including the use of their remains to explore evolutionary patterns in endogenous retrovirus-like elements across time [66] (Figure 1 and Figure 3). Early DNA work on the woolly mammoth, however, focused on its evolutionary relationship with extant proboscideans.
Complete mitogenomes and nuclear sequences revealed that it is most closely related to the Asian elephant (Elephas maximus) [67,68,69,70]. More recent studies have tried to unravel the genetic structure and population size changes within woolly mammoths through time. Whereas the first studies mainly used small nuclear markers, or short stretches of mitochondrial DNA (mtDNA), to tackle these topics [71,72,73,74,75], complete mitogenomes have now become the norm [68,76,77,78,79,80,81]. Moreover, in their study, the authors of [82] used DNA from samples more than one million years old to explore the genetic relationships between woolly and Columbian mammoths (Mammuthus columbi) and their direct ancestors.
These studies have revealed a complex evolutionary history characterized by multiple replacement and local introgression events. Three highly divergent and geographically structured matrilineal clades have been described, but the timing and geographic origins of these clades remain debated [83]. Furthermore, around 25,000 years ago, only one clade persisted after it had replaced the clades endemic to Siberia and Europe in an east-to-west fashion [74,75]. Whether the replacement of mitochondrial clades throughout the woolly mammoth distribution was caused by genetic drift, selective advantage, or coincided with climatic and/or anthropogenic disturbances remains unclear [71,74,75,79].
To study behaviour, palaeodiet, and social structure, stable isotope analysis has been a popular tool. Nevertheless, studies have also used biases in sex ratios derived from genomic data [92], comparisons of the ratio of mitochondrial and nuclear coalescent dates [93], and testosterone from ancient hair shafts to study social structure and life history traits in woolly mammoths [94].
Woolly mammoths had a distinct diet rich in C3 plants such as grasses and sedges (e.g., [95,96]), characterised by elevated δ15N prints. Multiple hypotheses have been postulated to explain the high δ15N values coupled with depleted δ13C values, including niche partitioning and coprophagy [95,97,98,99,100]. While this pattern is observed in mammoths on both sides of the Bering land bridge, geographic variation in isotopic signatures does exist, reflecting regional differences in precipitation and vegetation [101,102].
A well-studied topic within woolly mammoth research is the timing and cause of its extinction. Two phases within the extinction process have received considerable attention [103]: a first one during the Pleistocene/Holocene transition when mammoths went extinct on the mainland, and a second one during the Holocene when two mammoth populations isolated on islands went extinct, marking the global extinction of the woolly mammoth.
To determine the ultimate cause of the disappearance of the mainland woolly mammoth population at the end of the Pleistocene, studies have used combinations of DNA markers and radiocarbon dates to model the mammoth’s distribution in relation to vegetation changes and humans, but the results have remained inconclusive [35,104,105,106]. Genetic studies on both mitochondrial and nuclear genomes show that the woolly mammoth had a relative stable population size throughout the last glacial period on both sides of the Bering land bridge, but suffered a steep decline around 12,000 years ago, coinciding with the onset of the dramatic climate changes characteristic of the early Holocene [10,74,75]. While studies of δ15N and δ13C of mammoths from sites on the East European Plains have indicated that extinction was preceded by nutritional stress [29,79,107], no such patterns were found in mammoths from northeastern Siberia, indicating a complex extinction process throughout the woolly mammoth’s range [108].
Whereas explanations for the mainland extinction of the woolly mammoth mainly revolve around the relative importance of climate change and anthropogenic effects, other events likely caused the extinction of the woolly mammoth island populations during the Holocene. Using sediment DNA, three coprophilous fungal spore types, and directly dated radiocarbon remains as proxies for megafauna presence, ref. [109] found that the mammoths disappeared on St. Paul Island in Alaska as a result of fresh water scarcity. The circumstances surrounding the extinction of woolly mammoths on Wrangel Island are less clear. Genetic data showed that the early island population went through a bottleneck event and lost much of its genetic diversity, after which it remained constant [72,73], although other studies found extensive genetic drift in the island population [76,110]. Furthermore, stable isotope analysis did not find any evidence for habitat deterioration on the island [108,111]. Altogether, genetic, isotopic, and radiocarbon data all suggest that the extinction must have happened abruptly.
Many studies on woolly mammoths have focused on single biomolecules, whereas more recent studies have shown a trend towards a more integrative approach. For example, ref. [80] combined an extensive series of radiocarbon dates and mitogenome data to establish the origin of the founding population on Wrangel Island and determine the final extinction date of the woolly mammoth approximately 4000 years ago. In another study, ref. [79] showed the strength of combining methods by studying both stable isotopes and mtDNA to get a better understanding of woolly mammoth population dynamics in Central Europe. Despite this work, much uncertainty remains about the extinction of the woolly mammoth.

2.3. Woolly Rhinoceros

Similar to cave bears and woolly mammoths, the woolly rhinoceros (Coelodonta antiquitatis) was a megaherbivore that was widespread in Eurasia during the Late Pleistocene. Radiocarbon records suggest that the woolly rhinoceros went extinct around 14,000 years ago, after a range contraction towards northeastern Siberia [112] (Figure 2). Although not as well studied as other prominent Pleistocene megafauna, biomolecules such as stable isotopes and aDNA have contributed to our understanding of the woolly rhinoceros (Figure 1 and Figure 3).
Firstly, stable isotopes (δ13C and δ15N) extracted from bone, soft tissue, and horn have been used to investigate the diet of woolly rhinoceros [95,113]. The authors of [95] found that the woolly rhinoceros had similar isotopic compositions to woolly mammoths, suggesting that they had a similar staple diet. Furthermore, woolly rhinoceros had seasonal differences in its diet, with more graminoid plants consumed in the summer and wooded and shrub plants during the winter [113]. The results from these stable isotope analyses add to previous analyses based on pollen and macrofossil remains identified from mummified specimens [114,115].
Initial aDNA studies on woolly rhinoceros focused on placing this species in the Rhinocerotidae phylogeny [116,117]. By sequencing short fragments of mtDNA, ref. [116] determined that woolly rhinoceros were most closely related to the extant sumatran rhinoceros (Dicerorhinus sumatrensis), and that these taxa diverged ~26–21 million years ago. Following this, ref. [117] constructed the complete mitogenome of woolly rhinoceros, along with other Rhinocerotidae species, and confirmed the previously inferred placement of woolly rhinoceros in the phylogeny.
Later studies have investigated the demographic history of the woolly rhinoceros [104,118,119]. Mitochondrial and nuclear genome data indicate that the population size of woolly rhinoceros increased just prior to the Last Glacial Maximum (LGM) [104,118]. Furthermore, the presence of multiple mitochondrial clades and relatively high genome-wide diversity stipulates that woolly rhinoceros in northeastern Siberia did not experience genetic erosion preceding their extinction [118,119]. Recent stable isotope (δ13C and δ15N) evidence found stability in diet in the woolly rhinoceros population in northeastern Siberia over time, suggesting this area was important for maintaining this species during the warming period after the LGM.
Finally, ref. [118] also used aDNA to examine selection in the woolly rhinoceros, finding variants in genes that may be associated with cold-tolerance in this species (e.g., TRPA1). Thus, aDNA and stable isotopes are important biomolecules and biogeochemical traces that have so far shed light on the life and evolutionary history of woolly rhinoceros.

2.4. Bison

Bison is one of the few megafaunal genera that survived the Late Pleistocene/Holocene extinctions in Eurasia and North America. While two present-day representatives exist, the American bison (Bison bison) and the European bison (Bison bonasus), numerous species have been postulated to have coexisted in the Pleistocene based on morphology (e.g., Bison priscus, Bison schoetensacki, and Bison antiquus, among others) [120]. Both the American and European bison suffered extensive persecution in the 19th century [121], with the European bison being eradicated in the wild in the early 20th century [122]. The current population is the result of an extensive international cooperative breeding program that has made it possible to reintroduce more or less wild herds around Europe.
Notwithstanding the success of the effort to conserve the two species, sharp population declines have nevertheless resulted in reduced morphological and genetic variation in the persisting populations [123,124]. Consequently, research has been dedicated to exploring the extent of the genetic variation lost in the historical bottlenecks (e.g., [125,126,127,128,129]). Similarly, accounts of the ecology and ethology of bison stem from periods when these taxa were already greatly affected by human influence [130]. The ramifications are that only limited knowledge is accessible through the study of these relic bison.
Studies of the evolutionary history of prehistoric bison have been hampered by the morphological similarities between sympatric prehistoric bison species. In addition, bison remains are not easily distinguishable from those of members of the closely related Bos genus. Consequently, some of the earliest analyses of ancient bison DNA were conducted to facilitate species identification of bones (and residues on archaeological objects; e.g., [131,132]).
Mitochondrial data have been recovered from numerous bison specimens originating from large parts of its Holarctic distribution (e.g., [125,128,129,133,134,135,136,137,138,139,140,141,142,143]). These studies have, for instance, identified the existence of significant (but only occasionally associated) genetic and morphological variation. They have also been able to detect previously unknown dynamics between bison species and populations: e.g., the movements back and forth of diverse steppe bison (Bison priscus) lineages across the Bering land bridge facilitated by climatically induced periodic lowering of the sea level throughout the Pleistocene; the origin and subsequent spread of the American bison from south of the Laurentide and Cordilleran ice sheets; as well as the Late Pleistocene patterns of climatically driven mutual replacements of steppe bison and European bison in Europe.
However, studies using mtDNA, limited by the information obtainable from this uni-parentally inherited locus, have been unable to resolve all the questions about the evolution and taxonomy of the bison species [142]. For example, discordance between the inferred genetic affiliation from mtDNA and Y-chromosome sequences in contemporary European bison has been suggested to be due to a complex ancestry [144]. This is because the Y-chromosome sequence confirms a close relationship to American bison, while the mitochondrial genome, surprisingly, is more similar to the mitogenome of Bos primigenius/taurus. Although some ancient genome-wide sequence data, with the potential to resolve this issue, have been published [129,138,139,145,146], the evolutionary history of the European bison, and the reason for the discordance, remain a contested issue [120].
Attempts to reconstruct the past diet and behaviour of prehistoric bison have to date, for the most part, been conducted as separate biogeochemical studies (e.g., [130,147,148,149,150]). Without diminishing their significant scientific contribution, we argue that interdisciplinary studies that integrate morphological, isotopic, dietary, and genetic data would contextualise and enhance our knowledge of this enigmatic species complex. We are convinced that this type of integrated analysis can be used not only to relate reconstructions of the palaeoenvironment to the diet and behaviour (e.g., propensity to migrate) of extinct species, but also to investigate relationships between differences in behaviour (and the persisted integrity) of different genetic lineages. So far, with the exception of [138], such studies have mainly been conducted on individual exceptionally preserved specimens (e.g., [134,146]).

3. Faunal Transformations during and after the Late Pleistocene/Holocene Transition

Following the success of biomolecular studies of extinct species, it was not long before palaeo-biomolecular methods were used to investigate the biological history of domesticated species and their co-evolution with the humans who exploited them. Domestication has been described as the sustained human agency in the propagation and care of animals with strong selective advantages for both partners [151], the final consequence of which is the mutual shaping of both visible as direct modifications in the genomes of the animals and indirect patterns of change in the human genome.
The aim of early molecular studies studying the domestication of animals was to identify the wild progenitors and the patterns associated with this process [152,153], and subsequently to map the diversity of stocks in different geographical regions and historical periods, as well as to assess their relation to present-day stocks [154,155].
Domestication of animals by humans was initiated by the taming of the wolf (Canis lupus) about 15,000 years ago by hunting and gathering human populations. In the Fertile Crescent at approximately 11,000–10,000 years ago, a shift in human subsistence (from hunting and gathering to herding and cultivation of crops) was most likely triggered by climatic changes related to the global transition from the Late Pleistocene to the Holocene interglacial period [156]. At this time, the first true livestock, domestic sheep (Ovis aries), goats (Capra hircus), cattle (Bos taurus), and pigs (Sus scrofa) [157], appeared. Arguments have also been put forward that the changes in climate after the end of the Late Pleistocene may have led to greater phenotypic and behavioural variation in some species, making them particularly amenable for domestication [158]. This was followed by the domestication of the horse (Equus caballus) in Central Asia, chicken (Gallus gallus) in South-East Asia, and cat (Felix catus) in Northern Africa, among others, between 5500 and 4000 years ago [156].

3.1. Dogs

The complex issue of dog domestication has been addressed through a combination of single-molecule studies (aDNA sequence and genomic analyses, modern genomic analysis) and interdisciplinary research that integrates genetics, morphological assessment, and stable isotope analysis [159,160] (Figure 1, Figure 2 and Figure 4). Compared with the previous, single-topic studies, the integrated nature of the latter has allowed for a more detailed and complex evaluation of the initial stages of the domestication process.
Ancient DNA [161,162,163] and modern genomic analyses (e.g., [164]) have established that the dog was the first domesticated species and, even though there is still considerable debate regarding its exact timing, there is a consensus regarding the fact that dogs were domesticated by hunter-gatherers, thus predating the rise of agriculture.
For a long time, it was thought that the ancestor of the domestic dog was the modern grey wolf. While the grey wolf is the closest extant relative of dogs, and there is evidence of post-domestication gene flow between dogs and wolves [155,163,164,165], modern genomic analysis as well as aDNA analysis of fossil remains have proved that dogs were domesticated from a now-extinct wolf species and do not belong to the same lineage as modern wolves [155,161,163,164]. A Late Pleistocene origin for the most recent common ancestor of dogs and wolves has been suggested by aDNA analysis [161,162] and multidisciplinary studies [159,160].
The geographical origin of dog domestication has yet to be established with certainty, with ancient mitochondrial genomic analysis suggesting a European origin [163], perhaps from multiple and distinct wolf populations [159]. Modern genomic studies, however, propose a Central Asian [166] or Southeast Asian [167,168] origin. The authors of [169] inferred a contribution from Middle Eastern wolves. Moreover, an analysis of ancient mtDNA control region sequences of canid fossil remains from the Siberian Arctic indicates a not exclusively European origin [165]. The possibility of multiple domestication events has been put forward through ancient genomic and mtDNA sequence analysis [170], as well as a potential population replacement in Europe during the Neolithic, by a Near Eastern lineage [171,172]. However, the analysis of mitogenomic data from Neolithic dog remains has failed to corroborate either hypothesis [162].
Nevertheless, following the inception of the domestication process and the growing prevalence of agricultural practices, dogs conformed to the sedentary conditions of living with humans and livestock, as illustrated by two categories of studies. Firstly, modern genomic [173,174] and combined modern and aDNA studies [175] showed signs of selection on genes related to lipid or starch metabolism, behaviour, brain function, and immunity. Secondly, δ13C, δ15N, and N(34S)/N(32S) (representing the ratio for sulphur, abbreviated herein as δ34S) analyses of Stone Age [176,177] and Medieval [178,179,180] canid remains, have found isotopic signatures suggesting control of dogs’ dietary intake and their differential treatment food-wise.
Going forward from aDNA studies, recent advancements in analysing ancient dog specimens have been achieved by examining the yet poorly explored ancient RNA (aRNA) field. For instance, two promising proof-of-concept studies have reported the successful recovery of tissue-specific ancient RNA molecules from the well-preserved remains of a ~14,300-year-old ancient canid [19,181].
The existence of well-preserved short RNA transcripts with known biological functions in ancient specimens [19,181], as well as the ability of RNA molecules to be preserved through extended periods of time in specific conditions, opens the possibility for further analyses on evolution, selection signatures, and regulatory mechanisms at the transcriptomic level. Although the persistence of aRNA is expected to be far shorter than that of aDNA, thus limiting the applicability of this approach for ancient samples, this remains to be tested empirically.
The up and coming field of palaeotranscriptomics has the potential to contribute additional information to the far more mature aDNA field. Further analyses on aRNA sequences possibly surviving in well-preserved ancient and historical specimens might reveal novel insights into the history of extinct species that canonical aDNA studies have so far not been able to provide, for instance, tissue-specific expression profiles or the regulation of molecular pathways by small RNA transcripts such as microRNAs.

3.2. Sheep

Understanding of the complex process of sheep domestication has been greatly aided by the use of various molecular techniques, such as retrovirus integration analysis [182]; SNP analysis [183,184]; stable isotope analysis [185,186,187,188,189]; uni-parentally inherited DNA (mtDNA and Y-chromosomal DNA, both modern and ancient) (e.g., [190,191,192,193,194,195]); and, of late, large-scale genomic studies performed on modern samples [196,197,198,199,200] (Figure 1, Figure 2 and Figure 4). In addition, the differentiation from the morphologically similar goats (Capra hircus) has been facilitated by collagen-peptide mass fingerprinting [201,202] and recently published ancient mitogenomic sequences [203].
Modern DNA analysis, combined with archaeozoological assessment and aDNA analysis, has shown that initial sheep domestication took place approximately 11,000 years ago in the Fertile Crescent from several Moufloniformic populations [204,205,206,207]. From there, domestic sheep were disseminated to Europe, following three separate routes: the Danubian [191], the Northern European [198,208], as well as the Mediterranean [198]. Further analysis of lineage expansions from modern samples indicates two main Asian dispersal waves, with the Mongolian Plateau region acting as the secondary centre of migration towards China and the Indian subcontinent [190,197,199]. The ancient sea route connecting the Middle East to India served as yet another path of sheep dispersal towards the Indian subcontinent [209]. Studies concerned with elucidating local uni-parental genetic diversity of ancient samples before the Iron Age have illustrated the appearance of domestic mitochondrial lineages in the Alpine region [210], Russia [193], Estonia [192], Turkey [194], and China [211,212], while a recent interdisciplinary study, combining mitogenomic analysis and collagen-peptide mass fingerprinting, has illustrated the presence of domestic sheep in the interior of Central Asia ~8000 years ago, 3000 years earlier than previously assessed [203].
Analyses of uni-parentally inherited DNA sequences from modern [205,206,207,208,213,214,215,216] and ancient samples [194,210,212,217,218] have demonstrated the development of phylogeographic structure following domestication [197], possibly as a consequence of bottlenecks during migration. The clustering of both the deeply divergent rare Y-chromosomal haplotype (HY2) and the mitochondrial lineage C with Iranian mouflon, rather than with the wild mouflon from South East Anatolia, has been suggested to result from wild introgression [196,197], which has been proposed for other rare and geographically restricted mitochondrial lineages [196,197].
Besides wild introgression, the genetic history of sheep is marked by human-mediated trade, strong selective pressure, and admixture between different populations and eventually breeds [192,198,219]. While there are differences in the genetic makeup of different breeds as a result of adaptation to specific production requirements and environments, large-scale nuclear SNP analyses have illustrated that certain key genomic regions, such as those involved in coat colour, morphology (e.g., body size as well as the presence or absence of horns), and reproduction, display similar signs of selection across all breeds [198]. Local practices for breeding and trade during the Iron Age, Middle Ages, and into historical times in northern Europe [191,192] and Italy [217] have also been investigated through analyses of uni-parentally inherited aDNA markers.
Analyses of δ13C, δ15N, and N(18O)/N(16O), which represents the ratio for oxygen, abbreviated herein as δ18O, have similarly been used to examine signs of domestication (e.g., differences in birthing season between wild and domestic sheep) in Neolithic and Bronze Age samples [185,186,187,188,189]. Studies using either aDNA or stable isotopes [220] and multi-proxy studies combining analyses of mtDNA, collagen-peptide mass fingerprinting, and/or stable isotopes [221,222] have mainly focused on examining local management techniques across various historical periods.

3.3. Cattle

The process of cattle domestication has been investigated using various biomolecules ranging from mtDNA [223,224,225,226] and Y-chromosomes [227,228] to whole genomes [153,229], and stable isotope analysis [187,230] on both ancient and modern samples (Figure 1, Figure 2 and Figure 4). The progenitor of cattle, the extinct aurochs (Bos primigenius), had a wide late Pleistocene and early Holocene distribution, inhabiting the north of Africa, Europe, and Asia [231]. The aurochs’ domestication led to the appearance of taurine (Bos taurus) and zebu (Bos indicus) cattle. The major domestication events took place independently in the Neolithic in a two-step process [232]. First, ~10,500 years ago, taurine cattle were domesticated in the Near East from the western Eurasian Bos primigenius primigenius, followed 2000 years later by the domestication of indicine (zebu) cattle from the southern Asian Bos primigenius nomadicus in the Indus Valley [233]. In addition to this, an independent domestication event has been suggested to have occurred at least 10,660 years ago in eastern China. However, the status of this distinct taurine cattle as a ‘true’ domesticate and what contribution it has made to the nuclear gene pool of modern cattle are currently unknown [234].
East Asian cattle are characterised by high genetic diversity, indicative of a complicated history. Firstly, Bos taurus was introduced from West Asia ~5000 years ago [235], followed by Bos indicus ~3500 years ago [236]. The two species crossbred in central China [237]. Additional admixture between different bovine species has possibly resulted in shared derived alleles, e.g., from the banteng (Bos javanicus) into the Chinese Hainan cattle, and from taurine cattle into the yak (Bos grunniens) [229].
The domestication of European cattle in the Near East [223,225] is estimated to have involved a low number of individuals (~80 females) and to be the result of the natural mating behaviour of the wild aurochs [225]. Possible gene flow between aurochs and domesticated cattle has also been suggested in both the Near East and Europe [153,238]. Moreover, male-driven adaptive introgression from zebu bulls into taurine stock has been proposed to have been mediated by humans in response to climatic changes (sustained drought), nearly 4000 years ago [239].
The studies on stable isotopes offer new perspectives on the domestication process, with δ13C, δ15N, and δ18O usually used to investigate cattle management strategies. In Central China in the late Neolithic, cattle had a privileged status, as they were fed millet and kept within the settlements all year round [240]. This also contributed to supplementary feeding with leafy fodder becoming a widespread practice [241]. In addition, manipulation of female reproduction, in order to prolong the birthing season and enhance the production of milk, has been proposed to have been common already in the Neolithic based on stable isotope analyses [187,242,243].
An integrated study combining mtDNA, molecular sexing, radiocarbon dating, and stable isotopes (δ13C, δ15N, and δ34S), [244] was able to show that the most likely explanation for the presence of the wild north European P haplotype in Late Neolithic cattle from the site Links of Noltland in Orkney originated from the integration of female aurochs into domestic herds prior to the introduction to Orkney.

3.4. Pigs

The pig (Sus scrofa), is the only member of the diverse Suidae family that was domesticated [245], and is nowadays one of the most common livestock species worldwide. The long shared history with humans that has gradually shaped the genetic and phenotypic makeup of this widespread and opportunistic species has made it a suitable candidate for molecular genetic studies of domestication processes and evolutionary history.
Unlike other domestic species (e.g., dogs and horses) for which the geographical and temporal (spatio-temporal) origins remain unresolved, for pigs, there is solid evidence from material culture/archaeological material and genetics for the early stages of domestication [246,247,248]. Pigs were domesticated from the wild boar in East Anatolia and China about 10,000–9000 years ago from two divergent wild boar populations [249,250] (Figure 2). Owing to their omnivorous nature, wild boars are hypothesised to initially have been attracted to anthropogenic habitation sites as an easy way to access food, most probably being domesticated following a commensal pathway [251,252]. The two domestic lineages have subsequently experienced an intertwined genetic history as indicated by the analyses of pig mitochondrial genomes [246,253], microsatellite markers [254], and complete genome sequences [255].
The task of disentangling the multistage domestication process of suids has involved a number of disciplines (e.g., archaeology, biology, anthropology, genetics). Besides the traditional archaeological approach [256,257], additional insights into population dispersal and introgression events have been gained using modern genetic data [258,259,260,261]. However, the genetic legacy derived from modern organisms provides only a peek into this protracted and reticulated process; additional lines of evidence need to be drawn from palaeogenomic research. For instance, while studies of modern domestic pigs and wild boar have shown a lack of a Near Eastern genetic signal in nearly all modern European pigs [246], ancient mtDNA has provided evidence for human-mediated dispersal of domestic pigs from the Near East into Europe associated with the Neolithic expansion [262]. Furthermore, mtDNA analyses from archaeological specimens have shown that the maternal genetic architecture of pig populations has subsequently been influenced by gene flow between local European wild boars and introduced domestic stocks [262,263,264]. The complex history of translocations between southeastern Europe and Anatolia during the Bronze and Iron Ages [228] and changes in pig management strategies in northern Europe [265] have likewise become apparent by the analysis of maternal ancestry in pig samples from archaeological contexts. Contrary to European pigs, analyses of ancient mtDNA have suggested long-term genetic continuity between ancient and modern Chinese domestic pigs, as well as a lack of maternal genetic contribution from wild boars to modern domestic swineherds throughout East Asia [253].
Despite the unique power of ancient genomes/autosomal DNA to unveil human–pig relations, the vast majority of studies have relied on the analysis of diagnostic regions of the pig mtDNA [262,265,266,267] (Figure 4). Some studies combine these short stretches of mtDNA with geometric morphometric analyses of the archaeological remains [263,264,268,269]. Only a limited number of studies use mtDNA in conjunction with nuclear markers, such as the coat colour-coding gene MC1R [263,270]. Unknown subtleties pertaining to the spread and dynamics of pigs are only discernible through analyses of datasets sampling multiple geographical regions and time periods. Frantz and his colleagues [270] made a notable contribution in this direction by reconstructing mitochondrial and nuclear sequences of archaeological pig remains from various time periods from across Europe and the Near East.
Besides genomic data, ratios of stable carbon and nitrogen isotopes in bone collagen are useful instruments to explore human–suid relations, particularly reflecting dietary backgrounds, pig origins, and herd management [271,272]. Different foddering regimes have been illustrated for this flexible species by stable isotope signatures of ancient faunal samples from various regions and cultures. For instance, isotopic data of Pre-Pottery Neolithic pigs from Anatolia showed dietary differences between domestic pigs and their wild counterparts, suggesting that they were kept under cultural control [273]. In contrast, domestic pigs in Neolithic China were allowed to roam freely within human settlements much like their wild relatives [274]. Shifts from woodland resources to household waste in the Iron Age [275,276] followed by increased consumption of marine fish in the Middle Ages have been observed in pigs in Britain [277], while millet consumption has been suggested for ancient Chinese pigs [278,279,280]. Multiple husbandry practices have also been revealed by strontium isotope ratios in ancient Bali [281].

3.5. Horses

The horse is one of the most well studied species genetically, with almost 300 genomes of ancient horses having been sequenced [282] dating back 700,000 years in time [283,284] (Figure 1 and Figure 4). This has contributed significantly to studies on the evolutionary history of the wild horse (Equus ferus) (e.g., [283,284,285,286]) and to archaeological scenarios of domestication and human movements [282].
An initial domestication of horses happened at least 5500 years ago, possibly in the Western Eurasian Steppe, with the earliest evidence for harnessing, milking, and corralling belonging to the Botai culture of the Eneolithic period in Central Asia [287,288,289,290] (Figure 2). However, this lineage does not seem to have contributed significantly to modern domestic horses (Equus caballus), but instead gave rise to the feral Equus przewalski [288]. Multiple domestication events and possible domestication centers have been proposed [287,291], with the Iberian Peninsula displaying high levels of genetic diversity, as well as now extinct lineages that were still present in the region roughly 4000 years ago [292]. Ancient protein analysis of Equus remains dated to ~11,000 years ago [293] also found evidence for the exploitation of Equus in Canada by the Clovis hunters. While the remains of the earliest representative of the lineage that gave rise to modern domestic horses have been found in Hungary [292], neither the site nor time of their domestication are yet known [282].
Studies focused on understanding the genetic signature of domestication [289,294] have shown that modern horses contain high mutational loads, probably as a consequence of domestication or historical breeding practices. Initially, signatures of selection appeared in genes involved in cognitive functions that may have been key for taming horses, while changes in genes involved in locomotory development and the cardiac system may be the result of physiological adaptations to human use [289,294].
Following domestication, horses went through several human-mediated translocations, resulting in multiple population replacements. For instance, the ancestry of the earliest domestic populations of Central Asia was replaced in domestic stocks between 5000 and 4000 years ago. Moreover, after the 7th century, the Arab expansion into Europe and Asia led to changes in the genetic background of horses [287,292,295] and had a significant impact on horse genetic diversity. While modern horses display high levels of mtDNA diversity, representative of ancestral variability [291], they show virtually no Y-chromosome diversity [296]. The fact that ancient (~2800 years ago) horses had considerable Y-chromosome diversity [296] and that the majority of modern male lineages can be traced back to ancestors from the Orient [292,295] suggest that early domestication events involved a larger male stock [282,287] and that the Arab and Mongolian practice of selecting only a limited number of stallions for reproduction led to the observed decrease in Y-chromosome diversity [282,287,292,295]. This is further substantiated by horses dating to the Roman period not having the same decrease in Y-chromosome variability, suggesting that Romans did not practice a similar male-oriented breeding strategy [282,287,292].
Stable isotope analyses of horse remains dating to various periods such as the Plio-Pleistocene [297], the Bronze Age [298], and the Early Modern Period [299] have illustrated their dietary preferences in South American regions and the northern Kazakh steppe, as well as the shift in seasonal diet for the Przewalski’s horses of the Dzungarian Gobi.
As shown above, biomolecular studies have offered insight into the role and the treatment of horses by distinct historical societies.

3.6. Cats

Little molecular data are available regarding cat (Felis catus) domestication (Figure 1 and Figure 3), with much information having been obtained through the study of alternative resources, for example, historical documents, art objects, or osteological material [300]. However, some modern and ancient mtDNA [300,301,302,303,304] and stable isotope [305,306] analyses have been generated.
Felis silvestris, the wild cat, is considered to have diverged into five distinct subspecies: the European wildcat (F. silvestris silvestris, clade I), Southern African wildcat (F. silvestris cafra, clade II), Central Asian wildcat (F. silvestris ornata, clade III), Near Eastern wildcat (F. silvestris lybica, clade IV), and Chinese desert cat (F. silvestris bieii, clade V) [302,303]. For all modern cats, domestication started ~10,000 years ago, during the Neolithic, involving F. s. lybica in the Near East [302,304,307] (Figure 2). The Near East was inhabited by two distinct local populations, one being located in the Fertile Crescent and the other in Egypt [304]. Following domestication, cats, characterised as F. s. catus (the sixth subspecies, albeit recognised as the descendant of F. s. lybica), underwent human-mediated dispersal from the Near East [300,303].
In Europe, the Greeks, Phoenicians, and Romans are considered to have facilitated the spread of the domesticated cat within the continent. Pre-Roman samples have been identified in Western and Central Europe [308]. Recently, mitochondrial lineages associated with domesticated cats from the Near East was identified in cat remains dated to the Neolithic in Poland. A genetic contribution from individuals associated with both this Neolithic population expansion and the subsequent Roman-mediated spread has been identified in the gene pool of contemporary cats [300].
Studies of stable isotopes, usually δ13C and δ15N, have been used to investigate the commensal relationship between the cats and early farmers and to track common migration routes [305,306].

4. Final Remarks and Future Perspectives

In this compilation, our aim has been to outline important evolutionary events for a number of selected species, which have been reconstructed through the use of biomolecular research. For some, we have deliberately chosen to focus on the aspect of domestication, largely omitting research conducted on their wild counterparts. An outline of how different biomolecular and biogeochemical analyses have been used, which questions researchers investigated, and which conclusions have been reached based on their results is provided. Even though mtDNA and stable isotopes from bulk collagen have been used extensively in inferring ancient faunal dynamics (Figure 1 and Figure 5), the number of multiproxy biomolecular studies has increased in the last five years. While still rare, the integrated use of several ancient biomolecules and biogeochemical analyses is expected to provide a more coherent approach, evidently contributing unique insights and a more comprehensive reconstruction than individual proxies. In the future, the progressive reduction in costs for high throughput analyses is expected to remove the necessity for trade-offs limiting multiproxy biomolecular studies to exceptional single finds, and to extend their use to studies of large datasets, when examining ancient diversity in a palaeoenvironmental context.
In our review, we have focused on a few iconic and well-studied species with a largely Eurasian distribution. Additional studies illustrating the power of multiproxy biomolecular approaches are worth mentioning, like the one from North America by [309]. Using an integrated approach combining osteological age determination, aDNA, and stable isotope analysis (δ13C and δ15N), a degree of dietary flexibility not linked to age or haplogroup was demonstrated, supporting the hypothesis of direct human impact (overhunting) as the main factor leading to the decline and subsequent extinction of passenger pigeons (Ectopistes migratorius).
While this type of study is relatively more common for issues related to the palaeobiology and palaeoecology of extinct species and for finds from depositional environments with exceptional preservation (i.e., permafrost and caves), integrated analyses (e.g., combinations of stable isotopes, mtDNA, and protein-based methods) have occasionally been employed in studies of domestic species, and of datasets from equatorial and mid-latitude regions. For instance, ref. [310] combined genetic estimates of past effective population size with stable isotope analysis. They were able to infer stable population size and no significant changes in δ13C and δ15N isotope signatures over the last 44,000 years, suggesting that crested moa (Pachyornis australis) in New Zealand tracked its habitat through time with little consequence to population size.
The bottom line is that not all data of interest to the study of evolutionary and domestication processes can be found within the boundaries of individual disciplines. The contingent nature of these processes implies that different analytical approaches and biomolecules may be most informative at different points along their development. Despite the limitations imposed by preservation and challenges associated with simultaneous sample extraction for different biomolecular analyses (e.g., aDNA, stable isotopes, and uranium-thorium dating of bone collagen) from limited and/or valuable sources (e.g., rare and small taxa), the adoption of an integrated research design from the onset is expected to enable the co-creation of research questions and the potential for synergistic results. Further development and refinement of biomolecular methods will most likely lead to a reduction in the required sample quantities, adaptations of preparation protocols to facilitate multiple analyses from the same sample, and/or complementary analyses of alternative substrates (e.g., sedimentary aDNA and metabarcoding of bulk bone and middens for tracking presence/absence of species for palaeoenvironmental reconstructions, or the co-evolution of host and microbial/viral pathogens), promoting information-maximization.
With regard to the species addressed in this review, future integrative studies are expected to (1) directly integrate the underlying evolutionary and palaeoenvironmental processes, leading to megafaunal extinctions in the Late Pleistocene at an increasingly fine-scale geographic and temporal resolution; and (2) provide new details on the domestication and dispersal of animals that will contribute to more complex and multifaceted reconstructions of the practices of past societies. Together, the in-depth knowledge that will be gained will provide information available to policy-makers in order to influence measures for the management and conservation of modern counterparts and wildlife in general.

Author Contributions

Conceptualization, I.N.M. and B.S.K.; Methodology, I.N.M., N.C., A.H. and B.S.K.; Writing—Original Draft Preparation, E.R., A.A., N.C., M.D., A.H., E.L., C.I.M., I.R., E.M.-S., B.S.K., and I.N.M.; Writing—Review & Editing, E.R., I.N.M. and E.L.; Visualization, N.C. and A.H.; Supervision, I.N.M. and B.S.K.; Project Administration, I.N.M.; Funding Acquisition, I.N.M. All authors have read and agreed to the published version of the manuscript.

Funding

I.N.M has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 885088. A.H. and B.K. were supported by a grant of the Romanian Ministry of Education and Research, CNCS/CCCDI–UEFISCDI, project number PN-III-P4-ID-PCE-2020-0518, within PNCDI III. E.M.-S. acknowledges funding from the Strategic Research Area (SFO) program of the Swedish Research Council (VR) through Stockholm University.

Institutional Review Board Statement

Not applicable.

Data Availability Statement

All data used to generate the figures in the text are openly available in FigShare, at 10.6084/m9.figshare.14900976.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Pruvost, M.; Bellone, R.; Benecke, N.; Sandoval-Castellanos, E.; Cieslak, M.; Kuznetsova, T.; Morales-Muñiz, A.; O’Connor, T.; Reissmann, M.; Hofreiter, M.; et al. Genotypes of Predomestic Horses Match Phenotypes Painted in Paleolithic Works of Cave Art. Proc. Natl. Acad. Sci. USA 2011. [Google Scholar] [CrossRef] [Green Version]
  2. Lindqvist, C.; Rajora, O.P. Paleogenomics: Genome-Scale Analysis of Ancient DNA; Springer: Cham, Switzerland, 2019; ISBN 9783030047535. [Google Scholar]
  3. Birks, H.J.B. Paleoecology. In Encyclopedia of Ecology; Elsevier: Amsterdam, The Netherlands, 2019; pp. 494–504. [Google Scholar]
  4. Craig, O.E.; Steele, V.J.; Fischer, A.; Hartz, S.; Andersen, S.H.; Donohoe, P.; Glykou, A.; Saul, H.; Jones, D.M.; Koch, E.; et al. Ancient Lipids Reveal Continuity in Culinary Practices across the Transition to Agriculture in Northern Europe. Proc. Natl. Acad. Sci. USA 2011, 108, 17910–17915. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  5. Green, E.J.; Speller, C.F. Novel Substrates as Sources of Ancient DNA: Prospects and Hurdles. Genes 2017, 8, 180. [Google Scholar] [CrossRef] [Green Version]
  6. Slon, V.; Hopfe, C.; Weiß, C.L.; Mafessoni, F.; de la Rasilla, M.; Lalueza-Fox, C.; Rosas, A.; Soressi, M.; Knul, M.V.; Miller, R.; et al. Neandertal and Denisovan DNA from Pleistocene Sediments. Science 2017, 356, 605–608. [Google Scholar] [CrossRef] [Green Version]
  7. Bocherens, H.; Fizet, M.; Mariotti, A. Diet, Physiology and Ecology of Fossil Mammals as Inferred from Stable Carbon and Nitrogen Isotope Biogeochemistry: Implications for Pleistocene Bears. Palaeogeogr. Palaeoclimatol. Palaeoecol. 1994, 107, 213–225. [Google Scholar] [CrossRef]
  8. Naito, Y.I.; Honch, N.V.; Chikaraishi, Y.; Ohkouchi, N.; Yoneda, M. Quantitative Evaluation of Marine Protein Contribution in Ancient Diets Based on Nitrogen Isotope Ratios of Individual Amino Acids in Bone Collagen: An Investigation at the Kitakogane Jomon Site. Am. J. Phys. Anthropol. 2010, 143, 31–40. [Google Scholar] [CrossRef]
  9. Higuchi, R.; Bowman, B.; Freiberger, M.; Ryder, O.A.; Wilson, A.C. DNA Sequences from the Quagga, an Extinct Member of the Horse Family. Nature 1984, 312, 282–284. [Google Scholar] [CrossRef] [PubMed]
  10. Palkopoulou, E.; Mallick, S.; Skoglund, P.; Enk, J.; Rohland, N.; Li, H.; Omrak, A.; Vartanyan, S.; Poinar, H.; Götherström, A.; et al. Complete Genomes Reveal Signatures of Demographic and Genetic Declines in the Woolly Mammoth. Curr. Biol. 2015, 25, 1395–1400. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  11. Breker, M.; Schuldiner, M. The Emergence of Proteome-Wide Technologies: Systematic Analysis of Proteins Comes of Age. Nat. Rev. Mol. Cell Biol. 2014, 15, 453–464. [Google Scholar] [CrossRef] [PubMed]
  12. Guil-Guerrero, J.L.; Tikhonov, A.; Rodríguez-García, I.; Protopopov, A.; Grigoriev, S.; Ramos-Bueno, R.P. The Fat from Frozen Mammals Reveals Sources of Essential Fatty Acids Suitable for Palaeolithic and Neolithic Humans. PLoS ONE 2014, 9, e84480. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  13. Guil-Guerrero, J.L.; Rodríguez-García, I.; Kirillova, I.; Shidlovskiy, F.; Ramos-Bueno, R.P.; Savvinov, G.; Tikhonov, A. The PUFA-Enriched Fatty Acid Profiles of Some Frozen Bison from the Early Holocene Found in the Siberian Permafrost. Sci. Rep. 2015, 5, 7926. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  14. Lucquin, A.; Gibbs, K.; Uchiyama, J.; Saul, H.; Ajimoto, M.; Eley, Y.; Radini, A.; Heron, C.P.; Shoda, S.; Nishida, Y.; et al. Ancient Lipids Document Continuity in the Use of Early Hunter-Gatherer Pottery through 9,000 Years of Japanese Prehistory. Proc. Natl. Acad. Sci. USA 2016, 113, 3991–3996. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  15. Courel, B.; Robson, H.K.; Lucquin, A.; Dolbunova, E.; Oras, E.; Adamczak, K.; Andersen, S.H.; Astrup, P.M.; Charniauski, M.; Czekaj-Zastawny, A.; et al. Organic Residue Analysis Shows Sub-Regional Patterns in the Use of Pottery by Northern European Hunter-Gatherers. R. Soc. Open Sci. 2020, 7, 192016. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  16. Gokhman, D.; Malul, A.; Carmel, L. Inferring Past Environments from Ancient Epigenomes. Mol. Biol. Evol. 2017, 34, 2429–2438. [Google Scholar] [CrossRef] [Green Version]
  17. Hanghøj, K.; Seguin-Orlando, A.; Schubert, M.; Madsen, T.; Pedersen, J.S.; Willerslev, E.; Orlando, L. Fast, Accurate and Automatic Ancient Nucleosome and Methylation Maps with epiPALEOMIX. Mol. Biol. Evol. 2016, 33, 3284–3298. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  18. Hanghøj, K.; Orlando, L. Ancient Epigenomics. In Paleogenomics; Springer: Cham, Switzerland, 2018; pp. 75–111. [Google Scholar]
  19. Fromm, B.; Tarbier, M.; Smith, O.; Marmol-Sanchez, E.; Dalen, L.; Gilbert, T.P.; Friedlander, M.R. Ancient microRNA Profiles of a 14,300-Year-Old Canid Samples Confirm Taxonomic Origin and Give Glimpses into Tissue-Specific Gene Regulation from the Pleistocene. RNA 2020. [Google Scholar] [CrossRef]
  20. Emerman, M.; Malik, H.S. Paleovirology--Modern Consequences of Ancient Viruses. PLoS Biol. 2010, 8, e1000301. [Google Scholar] [CrossRef]
  21. Warke, S.; Tembhurne, P.; Bobade, S.; Ingle, V.C. Paleovirology: Blessing or Curse of Ancient Viruses—A Review. Agric. Rev. 2019, 40, 329–333. [Google Scholar] [CrossRef]
  22. Shapiro, B.; Hofreiter, M. A Paleogenomic Perspective on Evolution and Gene Function: New Insights from Ancient DNA. Science 2014, 343, 1236573. [Google Scholar] [CrossRef] [PubMed]
  23. Orlando, L.; Gilbert, M.T.P.; Willerslev, E. Reconstructing Ancient Genomes and Epigenomes. Nat. Rev. Genet. 2015, 16, 395–408. [Google Scholar] [CrossRef] [PubMed]
  24. Leonardi, M.; Librado, P.; Der Sarkissian, C.; Schubert, M.; Alfarhan, A.H.; Alquraishi, S.A.; Al-Rasheid, K.A.S.; Gamba, C.; Willerslev, E.; Orlando, L. Evolutionary Patterns and Processes: Lessons from Ancient DNA. Syst. Biol. 2017, 66, e1–e29. [Google Scholar] [CrossRef] [PubMed]
  25. Cappellini, E.; Prohaska, A.; Racimo, F.; Welker, F.; Pedersen, M.W.; Allentoft, M.E.; de Barros Damgaard, P.; Gutenbrunner, P.; Dunne, J.; Hammann, S.; et al. Ancient Biomolecules and Evolutionary Inference. Annu. Rev. Biochem. 2018, 87, 1029–1060. [Google Scholar] [CrossRef] [Green Version]
  26. Scheu, A. Neolithic Animal Domestication as Seen from Ancient DNA. Quat. Int. 2018, 496, 102–107. [Google Scholar] [CrossRef]
  27. Brunson, K.; Reich, D. The Promise of Paleogenomics beyond Our Own Species. Trends Genet. 2019, 35, 319–329. [Google Scholar] [CrossRef]
  28. Mitchell, K.J.; Rawlence, N.J. Examining Natural History through the Lens of Palaeogenomics. Trends Ecol. Evol. 2021, 36, 258–267. [Google Scholar] [CrossRef] [PubMed]
  29. Drucker, D.G.; Stevens, R.E.; Germonpré, M.; Sablin, M.V.; Péan, S.; Bocherens, H. Collagen Stable Isotopes Provide Insights into the End of the Mammoth Steppe in the Central East European Plains during the Epigravettian. Quat. Res. 2018, 90, 457–469. [Google Scholar] [CrossRef] [Green Version]
  30. Von Seth, J.; Niemann, J.; Dalén, L. Genomics of Extinction. In Paleogenomics; Springer: Cham, Switzerland, 2018; pp. 393–418. [Google Scholar]
  31. Kathleen Lyons, S.; Amatangelo, K.L.; Behrensmeyer, A.K.; Bercovici, A.; Blois, J.L.; Davis, M.; DiMichele, W.A.; Du, A.; Eronen, J.T.; Tyler Faith, J.; et al. Holocene Shifts in the Assembly of Plant and Animal Communities Implicate Human Impacts. Nature 2015, 529, 80–83. [Google Scholar] [CrossRef] [PubMed]
  32. Hewitt, G. The Genetic Legacy of the Quaternary Ice Ages. Nature 2000, 405, 907–913. [Google Scholar] [CrossRef]
  33. Provan, J.; Bennett, K.D. Phylogeographic Insights into Cryptic Glacial Refugia. Trends Ecol. Evol. 2008, 23, 564–571. [Google Scholar] [CrossRef] [PubMed]
  34. Stewart, J.R.; Lister, A.M.; Barnes, I.; Dalén, L. Refugia Revisited: Individualistic Responses of Species in Space and Time. Proc. Biol. Sci. 2010, 277, 661–671. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  35. Barnosky, A.D.; Koch, P.L.; Feranec, R.S.; Wing, S.L.; Shabel, A.B. Assessing the Causes of Late Pleistocene Extinctions on the Continents. Science 2004, 306, 70–75. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  36. Stewart, M.; Christopher Carleton, W.; Groucutt, H.S. Climate Change, Not Human Population Growth, Correlates with Late Quaternary Megafauna Declines in North America. Nat. Commun. 2021, 12, 965. [Google Scholar] [CrossRef]
  37. Fordham, D.A.; Brown, S.C.; Reşit Akçakaya, H.; Brook, B.W.; Haythorne, S.; Manica, A.; Shoemaker, K.T.; Austin, J.J.; Blonder, B.; Pilowsky, J.; et al. Humans Hastened the Range Collapse and Extinction of Woolly Mammoth. bioRxiv 2021, 2021.02.17.431706. [Google Scholar]
  38. Isotopic Tracking of Large Carnivore Palaeoecology in the Mammoth Steppe. Quat. Sci. Rev. 2015, 117, 42–71. [CrossRef]
  39. Gretzinger, J.; Molak, M.; Reiter, E.; Pfrengle, S.; Urban, C.; Neukamm, J.; Blant, M.; Conard, N.J.; Cupillard, C.; Dimitrijević, V.; et al. Large-Scale Mitogenomic Analysis of the Phylogeography of the Late Pleistocene Cave Bear. Sci. Rep. 2019, 9, 10700. [Google Scholar] [CrossRef]
  40. Barlow, A.; Paijmans, J.L.A.; Alberti, F.; Gasparyan, B.; Bar-Oz, G.; Pinhasi, R.; Foronova, I.; Puzachenko, A.Y.; Pacher, M.; Dalén, L.; et al. Middle Pleistocene Genome Calibrates a Revised Evolutionary History of Extinct Cave Bears. Curr. Biol. 2021, 31, 1771–1779. [Google Scholar] [CrossRef]
  41. Pacher, M.; Stuart, A.J. Extinction Chronology and Palaeobiology of the Cave Bear (Ursus Spelaeus). Boreas 2009, 38, 189–206. [Google Scholar] [CrossRef]
  42. Krajcarz, M.; Pacher, M.; Krajcarz, M.T.; Laughlan, L.; Rabeder, G.; Sabol, M.; Wojtal, P.; Bocherens, H. Isotopic Variability of Cave Bears (δ15N, δ13C) across Europe during MIS 3. Quat. Sci. Rev. 2016, 131, 51–72. [Google Scholar] [CrossRef]
  43. Bocherens, H. Isotopic Insights on Cave Bear Palaeodiet. Hist. Biol. 2019, 31, 410–421. [Google Scholar] [CrossRef]
  44. Pérez-Ramos, A.; Romero, A.; Rodriguez, E.; Figueirido, B. Three-Dimensional Dental Topography and Feeding Ecology in the Extinct Cave Bear. Biol. Lett. 2020, 16, 20200792. [Google Scholar] [CrossRef] [PubMed]
  45. Naito, Y.I.; Meleg, I.N.; Robu, M.; Vlaicu, M.; Drucker, D.G.; Wißing, C.; Hofreiter, M.; Barlow, A.; Bocherens, H. Heavy Reliance on Plants for Romanian Cave Bears Evidenced by Amino Acid Nitrogen Isotope Analysis. Sci. Rep. 2020, 10, 6612. [Google Scholar] [CrossRef] [Green Version]
  46. Stiller, M.; Baryshnikov, G.; Bocherens, H.; Grandal d’Anglade, A.; Hilpert, B.; Münzel, S.C.; Pinhasi, R.; Rabeder, G.; Rosendahl, W.; Trinkaus, E.; et al. Withering Away--25,000 Years of Genetic Decline Preceded Cave Bear Extinction. Mol. Biol. Evol. 2010, 27, 975–978. [Google Scholar] [CrossRef] [PubMed]
  47. Fortes, G.G.; Grandal-d’Anglade, A.; Kolbe, B.; Fernandes, D.; Meleg, I.N.; García-Vázquez, A.; Pinto-Llona, A.C.; Constantin, S.; de Torres, T.J.; Ortiz, J.E.; et al. Ancient DNA Reveals Differences in Behaviour and Sociality between Brown Bears and Extinct Cave Bears. Mol. Ecol. 2016, 25, 4907–4918. [Google Scholar] [CrossRef] [Green Version]
  48. Knapp, M.; Rohland, N.; Weinstock, J.; Baryshnikov, G.; Sher, A.; Nagel, D.; Rabeder, G.; Pinhasi, R.; Schmidt, H.A.; Hofreiter, M. First DNA Sequences from Asian Cave Bear Fossils Reveal Deep Divergences and Complex Phylogeographic Patterns. Mol. Ecol. 2009, 18, 1225–1238. [Google Scholar] [CrossRef]
  49. Bon, C.; Berthonaud, V.; Fosse, P.; Gély, B.; Maksud, F.; Vitalis, R.; Philippe, M.; van der Plicht, J.; Elalouf, J.-M. Low Regional Diversity of Late Cave Bears Mitochondrial DNA at the Time of Chauvet Aurignacian Paintings. J. Archaeol. Sci. 2011, 38, 1886–1895. [Google Scholar] [CrossRef]
  50. Stiller, M.; Molak, M.; Prost, S.; Rabeder, G.; Baryshnikov, G.; Rosendahl, W.; Münzel, S.; Bocherens, H.; Grandal-d’Anglade, A.; Hilpert, B.; et al. Mitochondrial DNA Diversity and Evolution of the Pleistocene Cave Bear Complex. Quat. Int. 2014, 339–340, 224–231. [Google Scholar] [CrossRef]
  51. Andersen, K.K.; Svensson, A.; Johnsen, S.J.; Rasmussen, S.O.; Bigler, M.; Röthlisberger, R.; Ruth, U.; Siggaard-Andersen, M.-L.; Steffensen, J.P.; Dahl-Jensen, D. The Greenland Ice Core Chronology 2005, 15–42ka. Part 1: Constructing the Time Scale. Quat. Sci. Rev. 2006, 25, 3246–3257. [Google Scholar] [CrossRef] [Green Version]
  52. Veres, D.; Lane, C.S.; Timar-Gabor, A.; Hambach, U.; Constantin, D.; Szakács, A.; Fülling, A.; Onac, B.P. The Campanian Ignimbrite/Y5 Tephra Layer—A Regional Stratigraphic Marker for Isotope Stage 3 Deposits in the Lower Danube Region, Romania. Quat. Int. 2013, 293, 22–33. [Google Scholar] [CrossRef]
  53. Fitzsimmons, K.E.; Hambach, U.; Veres, D.; Iovita, R. The Campanian Ignimbrite Eruption: New Data on Volcanic Ash Dispersal and Its Potential Impact on Human Evolution. PLoS ONE 2013, 8, e65839. [Google Scholar] [CrossRef]
  54. Staubwasser, M.; Drăgușin, V.; Onac, B.P.; Assonov, S.; Ersek, V.; Hoffmann, D.L.; Veres, D. Impact of Climate Change on the Transition of Neanderthals to Modern Humans in Europe. Proc. Natl. Acad. Sci. USA 2018, 115, 9116–9121. [Google Scholar] [CrossRef] [Green Version]
  55. Obreht, I.; Zeeden, C.; Hambach, U.; Veres, D.; Marković, S.B.; Bösken, J.; Svirčev, Z.; Bačević, N.; Gavrilov, M.B.; Lehmkuhl, F. Tracing the Influence of Mediterranean Climate on Southeastern Europe during the Past 350,000 Years. Sci. Rep. 2016, 6, 36334. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  56. Sirocko, F.; Knapp, H.; Dreher, F.; Förster, M.W.; Albert, J.; Brunck, H.; Veres, D.; Dietrich, S.; Zech, M.; Hambach, U.; et al. The ELSA-Vegetation-Stack: Reconstruction of Landscape Evolution Zones (LEZ) from Laminated Eifel Maar Sediments of the Last 60,000 Years. Glob. Planet. Chang. 2016, 142, 108–135. [Google Scholar] [CrossRef]
  57. Fletcher, W.J.; Goñi, M.F.S.; Allen, J.R.M.; Cheddadi, R.; Combourieu-Nebout, N.; Huntley, B.; Lawson, I.; Londeix, L.; Magri, D.; Margari, V.; et al. Millennial-Scale Variability during the Last Glacial in Vegetation Records from Europe. Quat. Sci. Rev. 2010, 29, 2839–2864. [Google Scholar] [CrossRef]
  58. Orlando, L.; Bonjean, D.; Bocherens, H.; Thenot, A.; Argant, A.; Otte, M.; Hänni, C. Ancient DNA and the Population Genetics of Cave Bears (Ursus Spelaeus) through Space and Time. Mol. Biol. Evol. 2002, 19, 1920–1933. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  59. Loreille, O.; Orlando, L.; Patou-Mathis, M.; Philippe, M.; Taberlet, P.; Hänni, C. Ancient DNA Analysis Reveals Divergence of the Cave Bear, Ursus Spelaeus, and Brown Bear, Ursus Arctos, Lineages. Curr. Biol. 2001, 11, 200–203. [Google Scholar] [CrossRef]
  60. Bocherens, H.; Stiller, M.; Hobson, K.A.; Pacher, M.; Rabeder, G.; Burns, J.A.; Tütken, T.; Hofreiter, M. Niche Partitioning between Two Sympatric Genetically Distinct Cave Bears (Ursus Spelaeus and Ursus Ingressus) and Brown Bear (Ursus Arctos) from Austria: Isotopic Evidence from Fossil Bones. Quat. Int. 2011, 245, 238–248. [Google Scholar] [CrossRef]
  61. Münzel, S.C.; Stiller, M.; Hofreiter, M.; Mittnik, A.; Conard, N.J.; Bocherens, H. Pleistocene Bears in the Swabian Jura (Germany): Genetic Replacement, Ecological Displacement, Extinctions and Survival. Quat. Int. 2011, 245, 225–237. [Google Scholar] [CrossRef]
  62. Stuart, A.J.; Sulerzhitsky, L.D.; Orlova, L.A.; Kuzmin, Y.V.; Lister, A.M. The Latest Woolly Mammoths (Mammuthus Primigenius Blumenbach) in Europe and Asia: A Review of the Current Evidence. Quat. Sci. Rev. 2002, 21, 1559–1569. [Google Scholar] [CrossRef]
  63. Lister, A.M.; Stuart, A.J. The Impact of Climate Change on Large Mammal Distribution and Extinction: Evidence from the Last Glacial/interglacial Transition. Comptes Rendus Geosci. 2008, 340, 615–620. [Google Scholar] [CrossRef]
  64. Vartanyan, S.L.; Arslanov, K.A.; Tertychnaya, T.V.; Chernov, S.B. Radiocarbon Dating Evidence for Mammoths on Wrangel Island, Arctic Ocean, Until 2000 BC. Radiocarbon 1995, 37, 1–6. [Google Scholar] [CrossRef] [Green Version]
  65. Guthrie, R.D.; Dale Guthrie, R. Radiocarbon Evidence of Mid-Holocene Mammoths Stranded on an Alaskan Bering Sea Island. Nature 2004, 429, 746–749. [Google Scholar] [CrossRef] [PubMed]
  66. Greenwood, A.D.; Lee, F.; Capelli, C.; DeSalle, R.; Tikhonov, A.; Marx, P.A.; MacPhee, R.D. Evolution of Endogenous Retrovirus-like Elements of the Woolly Mammoth (Mammuthus Primigenius) and Its Relatives. Mol. Biol. Evol. 2001, 18, 840–847. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  67. Krause, J.; Dear, P.H.; Pollack, J.L.; Slatkin, M.; Spriggs, H.; Barnes, I.; Lister, A.M.; Ebersberger, I.; Pääbo, S.; Hofreiter, M. Multiplex Amplification of the Mammoth Mitochondrial Genome and the Evolution of Elephantidae. Nature 2006, 439, 724–727. [Google Scholar] [CrossRef] [PubMed]
  68. Enk, J.; Devault, A.; Debruyne, R.; King, C.E.; Treangen, T.; O’Rourke, D.; Salzberg, S.L.; Fisher, D.; MacPhee, R.; Poinar, H. Complete Columbian Mammoth Mitogenome Suggests Interbreeding with Woolly Mammoths. Genome Biol. 2011, 12, R51. [Google Scholar] [CrossRef] [Green Version]
  69. Rohland, N.; Malaspinas, A.-S.; Pollack, J.L.; Slatkin, M.; Matheus, P.; Hofreiter, M. Proboscidean Mitogenomics: Chronology and Mode of Elephant Evolution Using Mastodon as Outgroup. PLoS Biol. 2007, 5, e207. [Google Scholar] [CrossRef] [PubMed]
  70. Rohland, N.; Reich, D.; Mallick, S.; Meyer, M.; Green, R.E.; Georgiadis, N.J.; Roca, A.L.; Hofreiter, M. Genomic DNA Sequences from Mastodon and Woolly Mammoth Reveal Deep Speciation of Forest and Savanna Elephants. PLoS Biol. 2010, 8, e1000564. [Google Scholar] [CrossRef] [Green Version]
  71. Barnes, I.; Shapiro, B.; Lister, A.; Kuznetsova, T.; Sher, A.; Guthrie, D.; Thomas, M.G. Genetic Structure and Extinction of the Woolly Mammoth, Mammuthus Primigenius. Curr. Biol. 2007, 17, 1072–1075. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  72. Nyström, V.; Dalén, L.; Vartanyan, S.; Lidén, K.; Ryman, N.; Angerbjörn, A. Temporal Genetic Change in the Last Remaining Population of Woolly Mammoth. Proc. Biol. Sci. 2010, 277, 2331–2337. [Google Scholar] [CrossRef] [Green Version]
  73. Nyström, V.; Humphrey, J.; Skoglund, P.; McKeown, N.J.; Vartanyan, S.; Shaw, P.W.; Lidén, K.; Jakobsson, M.; Barnes, I.; Angerbjörn, A.; et al. Microsatellite Genotyping Reveals End-Pleistocene Decline in Mammoth Autosomal Genetic Variation. Mol. Ecol. 2012, 21, 3391–3402. [Google Scholar] [CrossRef] [Green Version]
  74. Debruyne, R.; Chu, G.; King, C.E.; Bos, K.; Kuch, M.; Schwarz, C.; Szpak, P.; Gröcke, D.R.; Matheus, P.; Zazula, G.; et al. Out of America: Ancient DNA Evidence for a New World Origin of Late Quaternary Woolly Mammoths. Curr. Biol. 2008, 18, 1320–1326. [Google Scholar] [CrossRef] [Green Version]
  75. Palkopoulou, E.; Dalén, L.; Lister, A.M.; Vartanyan, S.; Sablin, M.; Sher, A.; Edmark, V.N.; Brandström, M.D.; Germonpré, M.; Barnes, I.; et al. Holarctic Genetic Structure and Range Dynamics in the Woolly Mammoth. Proc. Biol. Sci. 2013, 280, 20131910. [Google Scholar] [CrossRef] [Green Version]
  76. Pečnerová, P.; Palkopoulou, E.; Wheat, C.W.; Skoglund, P.; Vartanyan, S.; Tikhonov, A.; Nikolskiy, P.; van der Plicht, J.; Díez-Del-Molino, D.; Dalén, L. Mitogenome Evolution in the Last Surviving Woolly Mammoth Population Reveals Neutral and Functional Consequences of Small Population Size. Evol. Lett. 2017, 1, 292–303. [Google Scholar] [CrossRef]
  77. Chang, D.; Knapp, M.; Enk, J.; Lippold, S.; Kircher, M.; Lister, A.; MacPhee, R.D.E.; Widga, C.; Czechowski, P.; Sommer, R.; et al. The Evolutionary and Phylogeographic History of Woolly Mammoths: A Comprehensive Mitogenomic Analysis. Sci. Rep. 2017, 7, 44585. [Google Scholar] [CrossRef] [Green Version]
  78. Enk, J.; Devault, A.; Widga, C.; Saunders, J.; Szpak, P.; Southon, J.; Rouillard, J.-M.; Shapiro, B.; Brian Golding, G.; Zazula, G.; et al. Mammuthus Population Dynamics in Late Pleistocene North America: Divergence, Phylogeography, and Introgression. Front. Ecol. Evol. 2016, 4, 42. [Google Scholar] [CrossRef] [Green Version]
  79. Fellows Yates, J.A.; Drucker, D.G.; Reiter, E.; Heumos, S.; Welker, F.; Münzel, S.C.; Wojtal, P.; Lázničková-Galetová, M.; Conard, N.J.; Herbig, A.; et al. Central European Woolly Mammoth Population Dynamics: Insights from Late Pleistocene Mitochondrial Genomes. Sci. Rep. 2017, 7, 17714. [Google Scholar] [CrossRef]
  80. Dehasque, M.; Pečnerová, P.; Muller, H.; Tikhonov, A.; Nikolskiy, P.; Tsigankova, V.I.; Danilov, G.K.; Díez-del-Molino, D.; Vartanyan, S.; Dalén, L.; et al. Combining Bayesian Age Models and Genetics to Investigate Population Dynamics and Extinction of the Last Mammoths in Northern Siberia. Quat. Sci. Rev. 2021, 259, 106913. [Google Scholar] [CrossRef]
  81. Gilbert, M.T.P.; Drautz, D.I.; Lesk, A.M.; Ho, S.Y.W.; Qi, J.; Ratan, A.; Hsu, C.-H.; Sher, A.; Dalén, L.; Götherström, A.; et al. Intraspecific Phylogenetic Analysis of Siberian Woolly Mammoths Using Complete Mitochondrial Genomes. Proc. Natl. Acad. Sci. USA 2008, 105, 8327–8332. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  82. Van der Valk, T.; Pečnerová, P.; Díez-Del-Molino, D.; Bergström, A.; Oppenheimer, J.; Hartmann, S.; Xenikoudakis, G.; Thomas, J.A.; Dehasque, M.; Sağlıcan, E.; et al. Million-Year-Old DNA Sheds Light on the Genomic History of Mammoths. Nature 2021, 591, 265–269. [Google Scholar] [CrossRef] [PubMed]
  83. Roca, A.L. Million-Year-Old DNA Provides a Glimpse of Mammoth Evolution. Nature 2021, 591, 208–209. [Google Scholar] [CrossRef]
  84. Members, N.G.I.C.P. North Greenland Ice Core Project members High-Resolution Record of Northern Hemisphere Climate Extending into the Last Interglacial Period. Nature 2004, 431, 147–151. [Google Scholar]
  85. Barker, S.; Knorr, G.; Edwards, R.L.; Parrenin, F.; Putnam, A.E.; Skinner, L.C.; Wolff, E.; Ziegler, M. 800,000 Years of Abrupt Climate Variability. Science 2011, 334, 347–351. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  86. Elderfield, H.; Ferretti, P.; Greaves, M.; Crowhurst, S.; McCave, I.N.; Hodell, D.; Piotrowski, A.M. Evolution of Ocean Temperature and Ice Volume through the Mid-Pleistocene Climate Transition. Science 2012, 337, 704–709. [Google Scholar] [CrossRef] [PubMed]
  87. Lisiecki, L.E.; Raymo, M.E. A Pliocene-Pleistocene Stack of 57 Globally Distributed Benthic δ18O Records. Paleoceanography 2005, 20, PA1003. [Google Scholar] [CrossRef] [Green Version]
  88. Waelbroeck, C.; Labeyrie, L.; Michel, E.; Duplessy, J.C.; McManus, J.F.; Lambeck, K.; Balbon, E.; Labracherie, M. Sea-Level and Deep Water Temperature Changes Derived from Benthic Foraminifera Isotopic Records. Quat. Sci. Rev. 2002, 21, 295–305. [Google Scholar] [CrossRef]
  89. Bond, G.; Heinrich, H.; Broecker, W.S.; Others, A. 11 Evidence for massive discharges of icebergs into the North Atlantic ocean during the last glacial period. Nature 1992, 360, 245–249. [Google Scholar] [CrossRef]
  90. Chapman, M.R.; Shackleton, N.J. Global Ice-Volume Fluctuations, North Atlantic Ice-Rafting Events, and Deep-Ocean Circulation Changes between 130 and 70 Ka. Geology 1999, 27, 795. [Google Scholar] [CrossRef]
  91. Blockley, S.P.E.; Bourne, A.J.; Brauer, A.; Davies, S.M.; Hardiman, M.; Harding, P.R.; Lane, C.S.; MacLeod, A.; Matthews, I.P.; Pyne-O’Donnell, S.D.F.; et al. Tephrochronology and the Extended Intimate (integration of Ice-Core, Marine and Terrestrial Records) Event Stratigraphy 8–128 Ka b2k. Quat. Sci. Rev. 2014, 106, 88–100. [Google Scholar] [CrossRef] [Green Version]
  92. Pečnerová, P.; Díez-Del-Molino, D.; Dussex, N.; Feuerborn, T.; von Seth, J.; van der Plicht, J.; Nikolskiy, P.; Tikhonov, A.; Vartanyan, S.; Dalén, L. Genome-Based Sexing Provides Clues about Behavior and Social Structure in the Woolly Mammoth. Curr. Biol. 2017, 27, 3505–3510.e3. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  93. Brandt, A.L.; Ishida, Y.; Georgiadis, N.J.; Roca, A.L. Forest Elephant Mitochondrial Genomes Reveal That Elephantid Diversification in Africa Tracked Climate Transitions. Mol. Ecol. 2012, 21, 1175–1189. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  94. Koren, L.; Matas, D.; Pečnerová, P.; Dalén, L.; Tikhonov, A.; Gilbert, M.T.P.; Wynne-Edwards, K.E.; Geffen, E. Testosterone in Ancient Hair from an Extinct Species. Palaeontology 2018, 61, 797–802. [Google Scholar] [CrossRef] [Green Version]
  95. Bocherens, H.; Pacaud, G.; Lazarev, P.A.; Mariotti, A. Stable Isotope Abundances (13C, 15N) in Collagen and Soft Tissues from Pleistocene Mammals from Yakutia: Implications for the Palaeobiology of the Mammoth Steppe. Palaeogeogr. Palaeoclimatol. Palaeoecol. 1996, 126, 31–44. [Google Scholar] [CrossRef]
  96. Schwartz-Narbonne, R.; Longstaffe, F.J.; Kardynal, K.J.; Druckenmiller, P.; Hobson, K.A.; Jass, C.N.; Metcalfe, J.Z.; Zazula, G. Reframing the Mammoth Steppe: Insights from Analysis of Isotopic Niches. Quat. Sci. Rev. 2019, 215, 1–21. [Google Scholar] [CrossRef]
  97. Clementz, M.T.; Fox-Dobbs, K.; Wheatley, P.V.; Koch, P.L.; Doak, D.F. Revisiting Old Bones: Coupled Carbon Isotope Analysis of Bioapatite and Collagen as an Ecological and Palaeoecological Tool. Geol. J. 2009, 44, 605–620. [Google Scholar] [CrossRef]
  98. Bocherens, H.; Fizet, M.; Mariotti, A.; Gangloff, R.A.; Burns, J.A. Contribution of Isotopic Biogeochemistry (13C,15N,18O) to the Paleoecology of Mammoths (mammuthus Primigenius). Hist. Biol. 1994, 7, 187–202. [Google Scholar] [CrossRef]
  99. Metcalfe, J.Z.; Longstaffe, F.J.; Hodgins, G. Proboscideans and Paleoenvironments of the Pleistocene Great Lakes: Landscape, Vegetation, and Stable Isotopes. Quat. Sci. Rev. 2013, 76, 102–113. [Google Scholar] [CrossRef]
  100. Schwartz-Narbonne, R.; Longstaffe, F.J.; Metcalfe, J.Z.; Zazula, G. Solving the Woolly Mammoth Conundrum: Amino Acid 15N-Enrichment Suggests a Distinct Forage or Habitat. Sci. Rep. 2015, 5, 9791. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  101. Iacumin, P.; Nikolaev, V.; Ramigni, M. C and N Stable Isotope Measurements on Eurasian Fossil Mammals, 40 000 to 10 000 Years BP: Herbivore Physiologies and Palaeoenvironmental Reconstruction. Palaeogeogr. Palaeoclimatol. Palaeoecol. 2000, 163, 33–47. [Google Scholar] [CrossRef]
  102. Szpak, P.; Gröcke, D.R.; Debruyne, R.; MacPhee, R.D.E.; Dale Guthrie, R.; Froese, D.; Zazula, G.D.; Patterson, W.P.; Poinar, H.N. Regional Differences in Bone Collagen δ13C and δ15N of Pleistocene Mammoths: Implications for Paleoecology of the Mammoth Steppe. Palaeogeogr. Palaeoclimatol. Palaeoecol. 2010, 286, 88–96. [Google Scholar] [CrossRef]
  103. Thomas, M.G. The Flickering Genes of the Last Mammoths. Mol. Ecol. 2012, 21, 3379–3381. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  104. Lorenzen, E.D.; Nogués-Bravo, D.; Orlando, L.; Weinstock, J.; Binladen, J.; Marske, K.A.; Ugan, A.; Borregaard, M.K.; Gilbert, M.T.P.; Nielsen, R.; et al. Species-Specific Responses of Late Quaternary Megafauna to Climate and Humans. Nature 2011, 479, 359–364. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  105. Nogués-Bravo, D.; Rodríguez, J.; Hortal, J.; Batra, P.; Araújo, M.B. Climate Change, Humans, and the Extinction of the Woolly Mammoth. PLoS Biol. 2008, 6, e79. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  106. Cooper, A.; Turney, C.; Hughen, K.A.; Brook, B.W.; McDonald, H.G.; Bradshaw, C.J.A. PALEOECOLOGY. Abrupt Warming Events Drove Late Pleistocene Holarctic Megafaunal Turnover. Science 2015, 349, 602–606. [Google Scholar] [CrossRef] [PubMed]
  107. Drucker, D.G.; Bocherens, H.; Péan, S. Isotopes Stables (13C, 15N) Du Collagène Des Mammouths de Mezhyrich (Epigravettien, Ukraine): Implications Paléoécologiques. L’Anthropologie 2014, 118, 504–517. [Google Scholar] [CrossRef]
  108. Kuitems, M.; van Kolfschoten, T.; Tikhonov, A.N.; van der Plicht, J. Woolly Mammoth δ13C and δ15N Values Remained Amazingly Stable throughout the Last ∼50,000 Years in North-Eastern Siberia. Quat. Int. 2019, 500, 120–127. [Google Scholar] [CrossRef]
  109. Graham, R.W.; Belmecheri, S.; Choy, K.; Culleton, B.J.; Davies, L.J.; Froese, D.; Heintzman, P.D.; Hritz, C.; Kapp, J.D.; Newsom, L.A.; et al. Timing and Causes of Mid-Holocene Mammoth Extinction on St. Paul Island, Alaska. Proc. Natl. Acad. Sci. USA 2016, 113, 9310–9314. [Google Scholar] [CrossRef] [Green Version]
  110. Pečnerová, P.; Díez-del-Molino, D.; Vartanyan, S.; Dalén, L. Changes in Variation at the MHC Class II DQA Locus during the Final Demise of the Woolly Mammoth. Sci. Rep. 2016, 6, 25274. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  111. Arppe, L.; Karhu, J.A.; Vartanyan, S.; Drucker, D.G.; Etu-Sihvola, H.; Bocherens, H. Thriving or Surviving? The Isotopic Record of the Wrangel Island Woolly Mammoth Population. Quat. Sci. Rev. 2019, 222, 105884. [Google Scholar] [CrossRef]
  112. Stuart, A.J.; Lister, A.M. Extinction Chronology of the Woolly Rhinoceros Coelodonta Antiquitatis in the Context of Late Quaternary Megafaunal Extinctions in Northern Eurasia. Quat. Sci. Rev. 2012, 51, 1–17. [Google Scholar] [CrossRef]
  113. Tiunov, A.V.; Kirillova, I.V. Stable Isotope (13 C/12 C and 15 N/14 N) Composition of the Woolly Rhinoceros Coelodonta Antiquitatis Horn Suggests Seasonal Changes in the Diet. Rapid Commun. Mass Spectrom. 2010, 24, 3146–3150. [Google Scholar] [CrossRef]
  114. Tolmachev, A. (Ed.) The Arctic Ocean and Its Coast in the Cenozoic Era; Amerind Publ. Co.: New Delhi, India, 1970. [Google Scholar]
  115. Hopkins, D.M.; Macneil, F.S.; Merklin, R.L.; Petrov, O.M. Quaternary Correlations across Bering Strait: Recent Soviet and American Studies Cast New Light on the History of the Bering Land Bridge. Science 1965, 147, 1107–1114. [Google Scholar] [CrossRef]
  116. Orlando, L.; Leonard, J.A.; Thenot, A.; Laudet, V.; Guerin, C.; Hänni, C. Ancient DNA Analysis Reveals Woolly Rhino Evolutionary Relationships. Mol. Phylogenet. Evol. 2003, 28, 485–499. [Google Scholar] [CrossRef]
  117. Willerslev, E.; Gilbert, M.T.P.; Binladen, J.; Ho, S.Y.W.; Campos, P.F.; Ratan, A.; Tomsho, L.P.; da Fonseca, R.R.; Sher, A.; Kuznetsova, T.V.; et al. Analysis of Complete Mitochondrial Genomes from Extinct and Extant Rhinoceroses Reveals Lack of Phylogenetic Resolution. BMC Evol. Biol. 2009, 9, 95. [Google Scholar] [CrossRef] [Green Version]
  118. Lord, E.; Dussex, N.; Kierczak, M.; Díez-Del-Molino, D.; Ryder, O.A.; Stanton, D.W.G.; Gilbert, M.T.P.; Sánchez-Barreiro, F.; Zhang, G.; Sinding, M.-H.S.; et al. Pre-Extinction Demographic Stability and Genomic Signatures of Adaptation in the Woolly Rhinoceros. Curr. Biol. 2020, 30, 3871–3879.e7. [Google Scholar] [CrossRef]
  119. Rey-Iglesia, A.; Lister, A.M.; Stuart, A.J.; Bocherens, H.; Szpak, P.; Willerslev, E.; Lorenzen, E.D. Late Pleistocene Paleoecology and Phylogeography of Woolly Rhinoceroses. Quat. Sci. Rev. 2021, 263, 106993. [Google Scholar] [CrossRef]
  120. Grange, T.; Brugal, J.-P.; Flori, L.; Gautier, M.; Uzunidis, A.; Geigl, E.-M. The Evolution and Population Diversity of Bison in Pleistocene and Holocene Eurasia: Sex Matters. Diversity 2018, 10, 65. [Google Scholar] [CrossRef] [Green Version]
  121. Sanderson, E.W.; Redford, K.H.; Weber, B.; Aune, K.; Baldes, D.; Berger, J.; Carter, D.; Curtin, C.; Derr, J.; Dobrott, S.; et al. The Ecological Future of the North American Bison: Conceiving Long-Term, Large-Scale Conservation of Wildlife. Conserv. Biol. 2008, 22, 252–266. [Google Scholar] [CrossRef] [Green Version]
  122. Pucek, Z.; IUCN/SSC Bison Specialist Group. European Bison: Status Survey and Conservation Action Plan; World Conservation Union: Gland, Switzerland; Cambridge, UK, 2004; ISBN 9782831707624. [Google Scholar]
  123. Wójcik, J.M.; Kawałko, A.; Tokarska, M.; Jaarola, M.; Vallenback, P.; Pertoldi, C. Post-Bottleneck mtDNA Diversity in a Free-Living Population of European Bison: Implications for Conservation. J. Zool. 2009, 277, 81–87. [Google Scholar] [CrossRef]
  124. Pertoldi, C.; Tokarska, M.; Wójcik, J.M.; Demontis, D.; Loeschcke, V.; Gregersen, V.R.; Coltman, D.; Wilson, G.A.; Randi, E.; Hansen, M.M.; et al. Depauperate Genetic Variability Detected in the American and European Bison Using Genomic Techniques. Biol. Direct 2009, 4, 48. [Google Scholar] [CrossRef] [Green Version]
  125. Anderung, C.; Baubliene, J.; Daugnora, L.; Götherström, A. Medieval Remains from Lithuania Indicate Loss of a Mitochondrial Haplotype in Bison Bonasus. Mol. Ecol. 2006, 15, 3083. [Google Scholar] [CrossRef]
  126. Douglas, K.C. Comparing the Genetic Diversity of Late Pleistocene Bison with Modern Bison Bison Using Ancient DNA Techniques and the Mitochondrial DNA Control Region. Master’s Thesis, Baylor University, Waco, TX, USA, 2006. [Google Scholar]
  127. Wecek, K.; Hartmann, S.; Paijmans, J.L.A.; Taron, U.; Xenikoudakis, G.; Cahill, J.A.; Heintzman, P.D.; Shapiro, B.; Baryshnikov, G.; Bunevich, A.N.; et al. Complex Admixture Preceded and Followed the Extinction of Wisent in the Wild. Mol. Biol. Evol. 2017, 34, 598–612. [Google Scholar] [CrossRef] [Green Version]
  128. Zazula, G.D.; Hall, E.; Gregory Hare, P.; Thomas, C.; Mathewes, R.; La Farge, C.; Martel, A.L.; Heintzman, P.D.; Shapiro, B. A Middle Holocene Steppe Bison and Paleoenvironments from the Versleuce Meadows, Whitehorse, Yukon, Canada. Can. J. Earth Sci. 2017, 54, 1138–1152. [Google Scholar] [CrossRef] [Green Version]
  129. Stronen, A.V.; Iacolina, L.; Pertoldi, C.; Tokarska, M.; Sørensen, B.S.; Bahrndorff, S.; Oleński, K.; Kamiński, S.; Nikolskiy, P. Genomic Variability in the Extinct Steppe Bison (Bison Priscus) Compared to the European Bison (Bison Bonasus). Mammal Res. 2019, 64, 127–131. [Google Scholar] [CrossRef]
  130. Julien, M.-A.; Bocherens, H.; Burke, A.; Drucker, D.G.; Patou-Mathis, M.; Krotova, O.; Péan, S. Were European Steppe Bison Migratory? 18O, 13C and Sr Intra-Tooth Isotopic Variations Applied to a Palaeoethological Reconstruction. Quat. Int. 2012, 271, 106–119. [Google Scholar] [CrossRef]
  131. Newman, M.E.; Parboosingh, J.S.; Bridge, P.J.; Ceri, H. Identification of Archaeological Animal Bone by PCR/DNA Analysis. J. Archaeol. Sci. 2002, 29, 77–84. [Google Scholar] [CrossRef]
  132. Nielsen-Marsh, C.M.; Ostrom, P.H.; Gandhi, H.; Shapiro, B.; Cooper, A.; Hauschka, P.V.; Collins, M.J. Sequence Preservation of Osteocalcin Protein and Mitochondrial DNA in Bison Bones Older than 55 Ka. Geology 2002, 30, 1099. [Google Scholar] [CrossRef]
  133. Shapiro, B.; Drummond, A.J.; Rambaut, A.; Wilson, M.C.; Matheus, P.E.; Sher, A.V.; Pybus, O.G.; Gilbert, M.T.P.; Barnes, I.; Binladen, J.; et al. Rise and Fall of the Beringian Steppe Bison. Science 2004, 306, 1561–1565. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  134. Kirillova, I.V.; Zanina, O.G.; Chernova, O.F.; Lapteva, E.G.; Trofimova, S.S.; Lebedev, V.S.; Tiunov, A.V.; Soares, A.E.R.; Shidlovskiy, F.K.; Shapiro, B. An Ancient Bison from the Mouth of the Rauchua River (Chukotka, Russia). Quat. Res. 2015, 84, 232–245. [Google Scholar] [CrossRef] [Green Version]
  135. Marsolier-Kergoat, M.-C.; Palacio, P.; Berthonaud, V.; Maksud, F.; Stafford, T.; Bégouën, R.; Elalouf, J.-M. Hunting the Extinct Steppe Bison (Bison Priscus) Mitochondrial Genome in the Trois-Frères Paleolithic Painted Cave. PLoS ONE 2015, 10, e0128267. [Google Scholar] [CrossRef] [PubMed]
  136. Massilani, D.; Guimaraes, S.; Brugal, J.-P.; Bennett, E.A.; Tokarska, M.; Arbogast, R.-M.; Baryshnikov, G.; Boeskorov, G.; Castel, J.-C.; Davydov, S.; et al. Past Climate Changes, Population Dynamics and the Origin of Bison in Europe. BMC Biol. 2016, 14, 93. [Google Scholar] [CrossRef]
  137. Heintzman, P.D.; Froese, D.; Ives, J.W.; Soares, A.E.R.; Zazula, G.D.; Letts, B.; Andrews, T.D.; Driver, J.C.; Hall, E.; Hare, P.G.; et al. Bison Phylogeography Constrains Dispersal and Viability of the Ice Free Corridor in Western Canada. Proc. Natl. Acad. Sci. USA 2016, 113, 8057–8063. [Google Scholar] [CrossRef] [Green Version]
  138. Soubrier, J.; Gower, G.; Chen, K.; Richards, S.M.; Llamas, B.; Mitchell, K.J.; Ho, S.Y.W.; Kosintsev, P.; Lee, M.S.Y.; Baryshnikov, G.; et al. Early Cave Art and Ancient DNA Record the Origin of European Bison. Nat. Commun. 2016, 7, 13158. [Google Scholar]
  139. Palacio, P.; Berthonaud, V.; Guérin, C.; Lambourdière, J.; Maksud, F.; Philippe, M.; Plaire, D.; Stafford, T.; Marsolier-Kergoat, M.-C.; Elalouf, J.-M. Genome Data on the Extinct Bison Schoetensacki Establish It as a Sister Species of the Extant European Bison (Bison Bonasus). BMC Evol. Biol. 2017, 17, 48. [Google Scholar] [CrossRef] [Green Version]
  140. Onar, V.; Soubrier, J.; Toker, N.Y.; van Loenen, A.; Llamas, B.; Siddiq, A.B.; Pasicka, E.; Tokarska, M. Did the Historical Range of the European Bison (Bison Bonasus, L.) Extend Further South?—A New Finding from the Yenikapı Metro and Marmaray Excavation, Turkey. Mammal Res. 2017, 62, 103–109. [Google Scholar] [CrossRef]
  141. Froese, D.; Stiller, M.; Heintzman, P.D.; Reyes, A.V.; Zazula, G.D.; Soares, A.E.R.; Meyer, M.; Hall, E.; Jensen, B.J.L.; Arnold, L.J.; et al. Fossil and Genomic Evidence Constrains the Timing of Bison Arrival in North America. Proc. Natl. Acad. Sci. USA 2017, 114, 3457–3462. [Google Scholar] [CrossRef] [Green Version]
  142. Vershinina, A.O.; Kapp, J.D.; Soares, A.E.R.; Heintzman, P.D.; Lowson, C.; Cassatt-Johnstone, M.; Shidlovskiy, F.K.; Kirillova, I.V.; Shapiro, B. Ancient DNA Analysis of a Holocene Bison from the Rauchua River, Northwestern Chukotka, and the Existence of a Deeply Divergent Mitochondrial Clade. Зooлoгический журнал 2019, 98, 1091–1099. [Google Scholar] [CrossRef]
  143. Neov, B.; Spassov, N.; Hristova, L.; Hristov, P.; Radoslavov, G. New Data on the Evolutionary History of the European Bison (Bison Bonasus) Based on Subfossil Remains from Southeastern Europe. Ecol. Evol. 2021, 11, 2842–2848. [Google Scholar] [CrossRef]
  144. Verkaar, E.L.C.; Nijman, I.J.; Beeke, M.; Hanekamp, E.; Lenstra, J.A. Maternal and Paternal Lineages in Cross-Breeding Bovine Species. Has Wisent a Hybrid Origin? Mol. Biol. Evol. 2004, 21, 1165–1170. [Google Scholar] [CrossRef] [Green Version]
  145. Decker, J.E.; Pires, J.C.; Conant, G.C.; McKay, S.D.; Heaton, M.P.; Chen, K.; Cooper, A.; Vilkki, J.; Seabury, C.M.; Caetano, A.R.; et al. Resolving the Evolution of Extant and Extinct Ruminants with High-Throughput Phylogenomics. Proc. Natl. Acad. Sci. USA 2009, 106, 18644–18649. [Google Scholar] [CrossRef] [Green Version]
  146. Funck, J.; Heintzman, P.D.; Murray, G.G.R.; Shapiro, B.; McKinney, H.; Huchet, J.-B.; Bigelow, N.; Druckenmiller, P.; Wooller, M.J. A Detailed Life History of a Pleistocene Steppe Bison (Bison Priscus) Skeleton Unearthed in Arctic Alaska. Quat. Sci. Rev. 2020, 249, 106578. [Google Scholar] [CrossRef]
  147. Bocherens, H.; Drucker, D.G.; Bonjean, D.; Bridault, A.; Conard, N.J.; Cupillard, C.; Germonpré, M.; Höneisen, M.; Münzel, S.C.; Napierala, H.; et al. Isotopic Evidence for Dietary Ecology of Cave Lion (Panthera Spelaea) in North-Western Europe: Prey Choice, Competition and Implications for Extinction. Quat. Int. 2011, 245, 249–261. [Google Scholar] [CrossRef]
  148. Bocherens, H.; Hofman-Kamińska, E.; Drucker, D.G.; Schmölcke, U.; Kowalczyk, R. European Bison as a Refugee Species? Evidence from Isotopic Data on Early Holocene Bison and Other Large Herbivores in Northern Europe. PLoS ONE 2015, 10, e0115090. [Google Scholar] [CrossRef] [PubMed]
  149. Bojar, A.-V.; Guja, O.; Pelc, A.; Piotrowska, N.; Vasile, Ş. Bison Bonasus Skull from the Bihor Mountains, Romania: Isotopic and Morphological Investigations. Holocene 2015, 25, 1134–1143. [Google Scholar] [CrossRef]
  150. Hofman-Kamińska, E.; Bocherens, H.; Drucker, D.G.; Fyfe, R.M.; Gumiński, W.; Makowiecki, D.; Pacher, M.; Piličiauskienė, G.; Samojlik, T.; Woodbridge, J.; et al. Adapt or die—Response of Large Herbivores to Environmental Changes in Europe during the Holocene. Glob. Change Biol. 2019, 25, 2915–2930. [Google Scholar] [CrossRef] [PubMed]
  151. Zeder, M.A.; Emshwiller, E.; Smith, B.D.; Bradley, D.G. Documenting Domestication: The Intersection of Genetics and Archaeology. Trends Genet. 2006, 22, 139–155. [Google Scholar] [CrossRef]
  152. Bailey, J.F.; Richards, M.B.; Macaulay, V.A.; Colson, I.B.; James, I.T.; Bradley, D.G.; Hedges, R.E.; Sykes, B.C. Ancient DNA Suggests a Recent Expansion of European Cattle from a Diverse Wild Progenitor Species. Proc. Biol. Sci. 1996, 263, 1467–1473. [Google Scholar] [PubMed]
  153. Park, S.D.E.; Magee, D.A.; McGettigan, P.A.; Teasdale, M.D.; Edwards, C.J.; Lohan, A.J.; Murphy, A.; Braud, M.; Donoghue, M.T.; Liu, Y.; et al. Genome Sequencing of the Extinct Eurasian Wild Aurochs, Bos Primigenius, Illuminates the Phylogeography and Evolution of Cattle. Genome Biol. 2015, 16, 234. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  154. Hermes, T.R.; Frachetti, M.D.; Voyakin, D.; Yerlomaeva, A.S.; Beisenov, A.Z.; Doumani Dupuy, P.N.; Papin, D.V.; Motuzaite Matuzeviciute, G.; Bayarsaikhan, J.; Houle, J.-L.; et al. High Mitochondrial Diversity of Domesticated Goats Persisted among Bronze and Iron Age Pastoralists in the Inner Asian Mountain Corridor. PLoS ONE 2020, 15, e0233333. [Google Scholar] [CrossRef]
  155. Bergström, A.; Frantz, L.; Schmidt, R.; Ersmark, E.; Lebrasseur, O.; Girdland-Flink, L.; Lin, A.T.; Storå, J.; Sjögren, K.-G.; Anthony, D.; et al. Origins and Genetic Legacy of Prehistoric Dogs. Science 2020, 370, 557–564. [Google Scholar] [CrossRef]
  156. McHugo, G.P.; Dover, M.J.; MacHugh, D.E. Unlocking the Origins and Biology of Domestic Animals Using Ancient DNA and Paleogenomics. BMC Biol. 2019, 17, 98. [Google Scholar] [CrossRef] [Green Version]
  157. Larson, G.; Piperno, D.R.; Allaby, R.G.; Purugganan, M.D.; Andersson, L.; Arroyo-Kalin, M.; Barton, L.; Climer Vigueira, C.; Denham, T.; Dobney, K.; et al. Current Perspectives and the Future of Domestication Studies. Proc. Natl. Acad. Sci. USA 2014, 111, 6139–6146. [Google Scholar] [CrossRef] [Green Version]
  158. Zeder, M.A. Why Evolutionary Biology Needs Anthropology: Evaluating Core Assumptions of the Extended Evolutionary Synthesis. Evol. Anthropol. 2018, 27, 267–284. [Google Scholar] [CrossRef]
  159. Baumann, C.; Pfrengle, S.; Münzel, S.C.; Molak, M.; Feuerborn, T.R.; Breidenstein, A.; Reiter, E.; Albrecht, G.; Kind, C.-J.; Verjux, C.; et al. A Refined Proposal for the Origin of Dogs: The Case Study of Gnirshöhle, a Magdalenian Cave Site. Sci. Rep. 2021, 11, 5137. [Google Scholar] [CrossRef]
  160. Germonpré, M.; Sablin, M.V.; Stevens, R.E.; Hedges, R.E.M.; Hofreiter, M.; Stiller, M.; Després, V.R. Fossil Dogs and Wolves from Palaeolithic Sites in Belgium, the Ukraine and Russia: Osteometry, Ancient DNA and Stable Isotopes. J. Archaeol. Sci. 2009, 36, 473–490. [Google Scholar] [CrossRef]
  161. Skoglund, P.; Ersmark, E.; Palkopoulou, E.; Dalén, L. Ancient Wolf Genome Reveals an Early Divergence of Domestic Dog Ancestors and Admixture into High-Latitude Breeds. Curr. Biol. 2015, 25, 1515–1519. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  162. Botigué, L.R.; Song, S.; Scheu, A.; Gopalan, S.; Pendleton, A.L.; Oetjens, M.; Taravella, A.M.; Seregély, T.; Zeeb-Lanz, A.; Arbogast, R.-M.; et al. Ancient European Dog Genomes Reveal Continuity since the Early Neolithic. Nat. Commun. 2017, 8, 16082. [Google Scholar] [CrossRef]
  163. Thalmann, O.; Shapiro, B.; Cui, P.; Schuenemann, V.J.; Sawyer, S.K.; Greenfield, D.L.; Germonpré, M.B.; Sablin, M.V.; López-Giráldez, F.; Domingo-Roura, X.; et al. Complete Mitochondrial Genomes of Ancient Canids Suggest a European Origin of Domestic Dogs. Science 2013, 342, 871–874. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  164. Freedman, A.H.; Gronau, I.; Schweizer, R.M.; Ortega-Del Vecchyo, D.; Han, E.; Silva, P.M.; Galaverni, M.; Fan, Z.; Marx, P.; Lorente-Galdos, B.; et al. Genome Sequencing Highlights the Dynamic Early History of Dogs. PLoS Genet. 2014, 10, e1004016. [Google Scholar] [CrossRef] [Green Version]
  165. Lee, E.J.; Merriwether, D.A.; Kasparov, A.K.; Nikolskiy, P.A.; Sotnikova, M.V.; Pavlova, E.Y.; Pitulko, V.V. Ancient DNA Analysis of the Oldest Canid Species from the Siberian Arctic and Genetic Contribution to the Domestic Dog. PLoS ONE 2015, 10, e0125759. [Google Scholar] [CrossRef]
  166. Shannon, L.M.; Boyko, R.H.; Castelhano, M.; Corey, E.; Hayward, J.J.; McLean, C.; White, M.E.; Abi Said, M.; Anita, B.A.; Bondjengo, N.I.; et al. Genetic Structure in Village Dogs Reveals a Central Asian Domestication Origin. Proc. Natl. Acad. Sci. USA 2015, 112, 13639–13644. [Google Scholar] [CrossRef] [Green Version]
  167. Wang, G.-D.; Zhai, W.; Yang, H.-C.; Fan, R.-X.; Cao, X.; Zhong, L.; Wang, L.; Liu, F.; Wu, H.; Cheng, L.-G.; et al. The Genomics of Selection in Dogs and the Parallel Evolution between Dogs and Humans. Nat. Commun. 2013, 4, 1860. [Google Scholar] [CrossRef] [Green Version]
  168. Wang, G.-D.; Zhai, W.; Yang, H.-C.; Wang, L.; Zhong, L.; Liu, Y.-H.; Fan, R.-X.; Yin, T.-T.; Zhu, C.-L.; Poyarkov, A.D.; et al. Out of Southern East Asia: The Natural History of Domestic Dogs across the World. Cell Res. 2016, 26, 21–33. [Google Scholar] [CrossRef] [PubMed]
  169. Vonholdt, B.M.; Pollinger, J.P.; Lohmueller, K.E.; Han, E.; Parker, H.G.; Quignon, P.; Degenhardt, J.D.; Boyko, A.R.; Earl, D.A.; Auton, A.; et al. Genome-Wide SNP and Haplotype Analyses Reveal a Rich History Underlying Dog Domestication. Nature 2010, 464, 898–902. [Google Scholar] [CrossRef] [Green Version]
  170. Frantz, L.A.F.; Mullin, V.E.; Pionnier-Capitan, M.; Lebrasseur, O.; Ollivier, M.; Perri, A.; Linderholm, A.; Mattiangeli, V.; Teasdale, M.D.; Dimopoulos, E.A.; et al. Genomic and Archaeological Evidence Suggest a Dual Origin of Domestic Dogs. Science 2016, 352, 1228–1231. [Google Scholar] [CrossRef] [PubMed]
  171. Deguilloux, M.F.; Moquel, J.; Pemonge, M.H.; Colombeau, G. Ancient DNA Supports Lineage Replacement in European Dog Gene Pool: Insight into Neolithic Southeast France. J. Archaeol. Sci. 2009, 36, 513–519. [Google Scholar] [CrossRef]
  172. Ollivier, M.; Tresset, A.; Frantz, L.A.F.; Bréhard, S.; Bălăşescu, A.; Mashkour, M.; Boroneanţ, A.; Pionnier-Capitan, M.; Lebrasseur, O.; Arbogast, R.-M.; et al. Dogs Accompanied Humans during the Neolithic Expansion into Europe. Biol. Lett. 2018, 14. [Google Scholar] [CrossRef]
  173. Axelsson, E.; Ratnakumar, A.; Arendt, M.-L.; Maqbool, K.; Webster, M.T.; Perloski, M.; Liberg, O.; Arnemo, J.M.; Hedhammar, A.; Lindblad-Toh, K. The Genomic Signature of Dog Domestication Reveals Adaptation to a Starch-Rich Diet. Nature 2013, 495, 360–364. [Google Scholar] [CrossRef]
  174. Wang, G.-D.; Shao, X.-J.; Bai, B.; Wang, J.; Wang, X.; Cao, X.; Liu, Y.-H.; Wang, X.; Yin, T.-T.; Zhang, S.-J.; et al. Structural Variation during Dog Domestication: Insights from Gray Wolf and Dhole Genomes. Natl. Sci. Rev. 2019, 6, 110–122. [Google Scholar] [CrossRef]
  175. Pendleton, A.L.; Shen, F.; Taravella, A.M.; Emery, S.; Veeramah, K.R.; Boyko, A.R.; Kidd, J.M. Comparison of Village Dog and Wolf Genomes Highlights the Role of the Neural Crest in Dog Domestication. BMC Biol. 2018, 16, 64. [Google Scholar] [CrossRef] [Green Version]
  176. Bocherens, H.; Drucker, D.G.; Germonpré, M.; Lázničková-Galetová, M.; Naito, Y.I.; Wissing, C.; Brůžek, J.; Oliva, M. Reconstruction of the Gravettian Food-Web at Předmostí I Using Multi-Isotopic Tracking (13C, 15N, 34S) of Bone Collagen. Quat. Int. 2015, 359–360, 211–228. [Google Scholar] [CrossRef]
  177. Fischer, A.; Olsen, J.; Richards, M.; Heinemeier, J.; Sveinbjörnsdóttir, Á.E.; Bennike, P. Coast–inland Mobility and Diet in the Danish Mesolithic and Neolithic: Evidence from Stable Isotope Values of Humans and Dogs. J. Archaeol. Sci. 2007, 34, 2125–2150. [Google Scholar] [CrossRef]
  178. Monagle, V.; Conrad, C.; Jones, E.L. What Makes a Dog? Stable Isotope Analysis and Human-Canid Relationships at Arroyo Hondo Pueblo. Open Quat. 2018, 4, 6. [Google Scholar] [CrossRef] [Green Version]
  179. Rick, T.C.; Culleton, B.J.; Smith, C.B.; Johnson, J.R.; Kennett, D.J. Stable Isotope Analysis of Dog, Fox, and Human Diets at a Late Holocene Chumash Village (CA-SRI-2) on Santa Rosa Island, California. J. Archaeol. Sci. 2011, 38, 1385–1393. [Google Scholar] [CrossRef]
  180. McManus-Fry, E.; Knecht, R.; Dobney, K.; Richards, M.P.; Britton, K. Dog-Human Dietary Relationships in Yup’ik Western Alaska: The Stable Isotope and Zooarchaeological Evidence from Pre-Contact Nunalleq. J. Archaeol. Sci. Rep. 2018, 17, 964–972. [Google Scholar] [CrossRef]
  181. Smith, O.; Dunshea, G.; Sinding, M.-H.S.; Fedorov, S.; Germonpre, M.; Bocherens, H.; Gilbert, M.T.P. Ancient RNA from Late Pleistocene Permafrost and Historical Canids Shows Tissue-Specific Transcriptome Survival. PLoS Biol. 2019, 17. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  182. Chessa, B.; Pereira, F.; Arnaud, F.; Amorim, A.; Goyache, F.; Mainland, I.; Kao, R.R.; Pemberton, J.M.; Beraldi, D.; Stear, M.J.; et al. Revealing the History of Sheep Domestication Using Retrovirus Integrations. Science 2009, 324, 532–536. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  183. Uzun, M.; Gutiérrez-Gil, B.; Arranz, J.-J.; San Primitivo, F.; Saatci, M.; Kaya, M.; Bayón, Y. Genetic Relationships among Turkish Sheep. Genet. Sel. Evol. 2006, 38, 513–524. [Google Scholar] [CrossRef]
  184. Handley, L.-J.L.; Byrne, K.; Santucci, F.; Townsend, S.; Taylor, M.; Bruford, M.W.; Hewitt, G.M. Genetic Structure of European Sheep Breeds. Heredity 2007, 99, 620–631. [Google Scholar] [CrossRef] [Green Version]
  185. Blaise, E.; Balasse, M. Seasonality and Season of Birth of Modern and Late Neolithic Sheep from South-Eastern France Using Tooth Enamel δ18O Analysis. J. Archaeol. Sci. 2011, 38, 3085–3093. [Google Scholar] [CrossRef] [Green Version]
  186. Tornero, C.; Bălăşescu, A.; Ughetto-Monfrin, J.; Voinea, V.; Balasse, M. Seasonality and Season of Birth in Early Eneolithic Sheep from Cheia (Romania): Methodological Advances and Implications for Animal Economy. J. Archaeol. Sci. 2013, 40, 4039–4055. [Google Scholar] [CrossRef]
  187. Balasse, M.; Boury, L.; Ughetto-Monfrin, J.; Tresset, A. Stable Isotope Insights (δ18O,δ13C) into Cattle and Sheep Husbandry at Bercy (Paris, France, 4th Millennium BC): Birth Seasonality and Winter Leaf Foddering. Environ. Archaeol. 2012, 17, 29–44. [Google Scholar] [CrossRef]
  188. Sjögren, K.-G.; Douglas Price, T. A Complex Neolithic Economy: Isotope Evidence for the Circulation of Cattle and Sheep in the TRB of Western Sweden. J. Archaeol. Sci. 2013, 40, 690–704. [Google Scholar] [CrossRef]
  189. Henton, E. The Combined Use of Oxygen Isotopes and Microwear in Sheep Teeth to Elucidate Seasonal Management of Domestic Herds: The Case Study of Çatalhöyük, Central Anatolia. J. Archaeol. Sci. 2012, 39, 3264–3276. [Google Scholar] [CrossRef]
  190. Ganbold, O.; Lee, S.-H.; Seo, D.; Paek, W.K.; Manjula, P.; Munkhbayar, M.; Lee, J.H. Genetic Diversity and the Origin of Mongolian Native Sheep. Livest. Sci. 2019, 220, 17–25. [Google Scholar] [CrossRef]
  191. Niemi, M.; Bläuer, A.; Iso-Touru, T.; Nyström, V.; Harjula, J.; Taavitsainen, J.-P.; Storå, J.; Lidén, K.; Kantanen, J. Mitochondrial DNA and Y-Chromosomal Diversity in Ancient Populations of Domestic Sheep (Ovis Aries) in Finland: Comparison with Contemporary Sheep Breeds. Genet. Sel. Evol. 2013, 45, 2. [Google Scholar] [CrossRef] [Green Version]
  192. Rannamäe, E.; Lõugas, L.; Speller, C.F.; Valk, H.; Maldre, L.; Wilczyński, J.; Mikhailov, A.; Saarma, U. Three Thousand Years of Continuity in the Maternal Lineages of Ancient Sheep (Ovis Aries) in Estonia. PLoS ONE 2016, 11, e0163676. [Google Scholar] [CrossRef]
  193. Dymova, M.A.; Zadorozhny, A.V.; Mishukova, O.V.; Khrapov, E.A.; Druzhkova, A.S.; Trifonov, V.A.; Kichigin, I.G.; Tishkin, A.A.; Grushin, S.P.; Filipenko, M.L. Mitochondrial DNA Analysis of Ancient Sheep from Altai. Anim. Genet. 2017, 48, 615–618. [Google Scholar] [CrossRef]
  194. Demirci, S.; Baştanlar, E.K.; Dağtaş, N.D.; Pişkin, E.; Engin, A.; Özer, F.; Yüncü, E.; Doğan, Ş.A.; Togan, İ. Mitochondrial DNA Diversity of Modern, Ancient and Wild Sheep (Ovis Gmelinii Anatolica) from Turkey: New Insights on the Evolutionary History of Sheep. PLoS ONE 2013, 8, e81952. [Google Scholar] [CrossRef] [Green Version]
  195. Brunson, K.; Lele, R.; Xin, Z.; Xiaoling, D.; Hui, W.; Jing, Z.; Flad, R. Zooarchaeology, Ancient mtDNA, and Radiocarbon Dating Provide New Evidence for the Emergence of Domestic Cattle and Caprines in the Tao River Valley of Gansu Province, Northwest China. J. Archaeol. Sci. Rep. 2020, 31, 102262. [Google Scholar] [CrossRef]
  196. Li, R.; Yang, P.; Li, M.; Fang, W.; Yue, X.; Nanaei, H.A.; Gan, S.; Du, D.; Cai, Y.; Dai, X.; et al. A Hu Sheep Genome with the First Ovine Y Chromosome Reveal Introgression History after Sheep Domestication. Sci. China Life Sci. 2020. [Google Scholar] [CrossRef] [PubMed]
  197. Lv, F.-H.; Peng, W.-F.; Yang, J.; Zhao, Y.-X.; Li, W.-R.; Liu, M.-J.; Ma, Y.-H.; Zhao, Q.-J.; Yang, G.-L.; Wang, F.; et al. Mitogenomic Meta-Analysis Identifies Two Phases of Migration in the History of Eastern Eurasian Sheep. Mol. Biol. Evol. 2015, 32, 2515–2533. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  198. Kijas, J.W.; Lenstra, J.A.; Hayes, B.; Boitard, S.; Porto Neto, L.R.; Cristobal, M.S.; Servin, B.; McCulloch, R.; Whan, V.; Gietzen, K.; et al. Genome-Wide Analysis of the World’s Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection. PLoS Biol. 2012, 10, e1001258. [Google Scholar] [CrossRef] [Green Version]
  199. Zhao, Y.-X.; Yang, J.; Lv, F.-H.; Hu, X.-J.; Xie, X.-L.; Zhang, M.; Li, W.-R.; Liu, M.-J.; Wang, Y.-T.; Li, J.-Q.; et al. Genomic Reconstruction of the History of Native Sheep Reveals the Peopling Patterns of Nomads and the Expansion of Early Pastoralism in East Asia. Mol. Biol. Evol. 2017, 34, 2380–2395. [Google Scholar] [CrossRef]
  200. Ciani, E.; Econogene Consortium; Mastrangelo, S.; Da Silva, A.; Marroni, F.; Ferenčaković, M.; Ajmone-Marsan, P.; Baird, H.; Barbato, M.; Colli, L.; et al. On the Origin of European Sheep as Revealed by the Diversity of the Balkan Breeds and by Optimizing Population-Genetic Analysis Tools. Genet. Sel. Evol. 2020, 52, 25. [Google Scholar] [CrossRef] [PubMed]
  201. Buckley, M.; Kansa, S.W.; Howard, S.; Campbell, S.; Thomas-Oates, J.; Collins, M. Distinguishing between Archaeological Sheep and Goat Bones Using a Single Collagen Peptide. J. Archaeol. Sci. 2010, 37, 13–20. [Google Scholar] [CrossRef]
  202. Prendergast, M.E.; Janzen, A.; Buckley, M.; Grillo, K.M. Sorting the Sheep from the Goats in the Pastoral Neolithic: Morphological and Biomolecular Approaches at Luxmanda, Tanzania. Archaeol. Anthropol. Sci. 2019, 11, 3047–3062. [Google Scholar] [CrossRef]
  203. Taylor, W.T.T.; Pruvost, M.; Posth, C.; Rendu, W.; Krajcarz, M.T.; Abdykanova, A.; Brancaleoni, G.; Spengler, R.; Hermes, T.; Schiavinato, S.; et al. Evidence for Early Dispersal of Domestic Sheep into Central Asia. Nat. Hum. Behav. 2021. [Google Scholar] [CrossRef]
  204. Zeder, M.A. Domestication and Early Agriculture in the Mediterranean Basin: Origins, Diffusion, and Impact. Proc. Natl. Acad. Sci. USA 2008, 105, 11597–11604. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  205. Meadows, J.R.S.; Cemal, I.; Karaca, O.; Gootwine, E.; Kijas, J.W. Five Ovine Mitochondrial Lineages Identified from Sheep Breeds of the near East. Genetics 2007, 175, 1371–1379. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  206. Hiendleder, S.; Kaupe, B.; Wassmuth, R.; Janke, A. Molecular Analysis of Wild and Domestic Sheep Questions Current Nomenclature and Provides Evidence for Domestication from Two Different Subspecies. Proc. Biol. Sci. 2002, 269, 893–904. [Google Scholar] [CrossRef] [Green Version]
  207. Hiendleder, S.; Lewalski, H.; Wassmuth, R.; Janke, A. The Complete Mitochondrial DNA Sequence of the Domestic Sheep (Ovis Aries) and Comparison with the Other Major Ovine Haplotype. J. Mol. Evol. 1998, 47, 441–448. [Google Scholar] [CrossRef]
  208. Tapio, M.; Marzanov, N.; Ozerov, M.; Cinkulov, M.; Gonzarenko, G.; Kiselyova, T.; Murawski, M.; Viinalass, H.; Kantanen, J. Sheep Mitochondrial DNA Variation in European, Caucasian, and Central Asian Areas. Mol. Biol. Evol. 2006, 23, 1776–1783. [Google Scholar] [CrossRef]
  209. Singh, S.; Kumar, S., Jr.; Kolte, A.P.; Kumar, S. Extensive Variation and Sub-Structuring in Lineage a mtDNA in Indian Sheep: Genetic Evidence for Domestication of Sheep in India. PLoS ONE 2013, 8, e77858. [Google Scholar] [CrossRef] [PubMed]
  210. Olivieri, C.; Ermini, L.; Rizzi, E.; Corti, G.; Luciani, S.; Marota, I.; De Bellis, G.; Rollo, F. Phylogenetic Position of a Copper Age Sheep (Ovis Aries) Mitochondrial DNA. PLoS ONE 2012, 7, e33792. [Google Scholar] [CrossRef] [Green Version]
  211. Cai, D.-W.; Han, L.; Zhang, X.-L.; Zhou, H.; Zhu, H. DNA Analysis of Archaeological Sheep Remains from China. J. Archaeol. Sci. 2007, 34, 1347–1355. [Google Scholar] [CrossRef]
  212. Cai, D.; Tang, Z.; Yu, H.; Han, L.; Ren, X.; Zhao, X.; Zhu, H.; Zhou, H. Early History of Chinese Domestic Sheep Indicated by Ancient DNA Analysis of Bronze Age Individuals. J. Archaeol. Sci. 2011, 38, 896–902. [Google Scholar] [CrossRef]
  213. Meadows, J.R.S.; Li, K.; Kantanen, J.; Tapio, M.; Sipos, W.; Pardeshi, V.; Gupta, V.; Calvo, J.H.; Whan, V.; Norris, B.; et al. Mitochondrial Sequence Reveals High Levels of Gene Flow between Breeds of Domestic Sheep from Asia and Europe. J. Hered. 2005, 96, 494–501. [Google Scholar] [CrossRef] [Green Version]
  214. Chen, S.-Y.; Duan, Z.-Y.; Sha, T.; Xiangyu, J.; Wu, S.-F.; Zhang, Y.-P. Origin, Genetic Diversity, and Population Structure of Chinese Domestic Sheep. Gene 2006, 376, 216–223. [Google Scholar] [CrossRef]
  215. Guo, J.; Du, L.-X.; Ma, Y.-H.; Guan, W.-J.; Li, H.-B.; Zhao, Q.-J.; Li, X.; Rao, S.-Q. A Novel Maternal Lineage Revealed in Sheep (Ovis Aries). Anim. Genet. 2005, 36, 331–336. [Google Scholar] [CrossRef] [PubMed]
  216. Pereira, F.; Davis, S.J.M.; Pereira, L.; McEvoy, B.; Bradley, D.G.; Amorim, A. Genetic Signatures of a Mediterranean Influence in Iberian Peninsula Sheep Husbandry. Mol. Biol. Evol. 2006, 23, 1420–1426. [Google Scholar] [CrossRef] [PubMed]
  217. Gabbianelli, F.; Gargani, M.; Pariset, L.; Mariotti, M.; Alhaique, F.; De Minicis, E.; Barelli, L.; Ciammetti, E.; Redi, F.; Valentini, A. Mitochondrial DNA Analysis of Medieval Sheep (Ovis Aries) in Central Italy Reveals the Predominance of Haplogroup B Already in the Middle Ages. Anim. Genet. 2015, 46, 329–332. [Google Scholar] [CrossRef]
  218. Kechin, A.A.; Dymova, M.A.; Tishkin, A.A.; Grushin, S.P.; Dashkovskiy, P.K.; Filipenko, M.L. Targeted Sequencing for Studying Economically Useful Traits and Phylogenetic Diversity of Ancient Sheep. Russ. J. Genet. 2019, 55, 1499–1505. [Google Scholar] [CrossRef]
  219. Niemi, M.; Sajantila, A.; Ahola, V.; Vilkki, J. Sheep and Cattle Population Dynamics Based on Ancient and Modern DNA Reflects Key Events in the Human History of the North-East Baltic Sea Region. J. Archaeol. Sci. Rep. 2018, 18, 169–173. [Google Scholar] [CrossRef]
  220. Valenzuela-Lamas, S.; Orengo, H.A.; Bosch, D.; Pellegrini, M.; Halstead, P.; Nieto-Espinet, A.; Trentacoste, A.; Jiménez-Manchón, S.; López-Reyes, D.; Jornet-Niella, R. Shipping Amphorae and Shipping Sheep? Livestock Mobility in the North-East Iberian Peninsula during the Iron Age Based on Strontium Isotopic Analyses of Sheep and Goat Tooth Enamel. PLoS ONE 2018, 13, e0205283. [Google Scholar] [CrossRef] [Green Version]
  221. Hermes, T.R.; Frachetti, M.D.; Doumani Dupuy, P.N.; Mar’yashev, A.; Nebel, A.; Makarewicz, C.A. Early Integration of Pastoralism and Millet Cultivation in Bronze Age Eurasia. Proc. Biol. Sci. 2019, 286, 20191273. [Google Scholar] [CrossRef]
  222. Birch, S.E.P.; Pilaar Birch, S.E.; Scheu, A.; Buckley, M.; Çakırlar, C. Combined Osteomorphological, Isotopic, aDNA, and ZooMS Analyses of Sheep and Goat Remains from Neolithic Ulucak, Turkey. Archaeol. Anthropol. Sci. 2019, 11, 1669–1681. [Google Scholar] [CrossRef] [Green Version]
  223. Troy, C.S.; MacHugh, D.E.; Bailey, J.F.; Magee, D.A.; Loftus, R.T.; Cunningham, P.; Chamberlain, A.T.; Sykes, B.C.; Bradley, D.G. Genetic Evidence for Near-Eastern Origins of European Cattle. Nature 2001, 410, 1088–1091. [Google Scholar] [CrossRef]
  224. Edwards, C.J.; MacHugh, D.E.; Dobney, K.M.; Martin, L.; Russell, N.; Horwitz, L.K.; McIntosh, S.K.; MacDonald, K.C.; Helmer, D.; Tresset, A.; et al. Ancient DNA Analysis of 101 Cattle Remains: Limits and Prospects. J. Archaeol. Sci. 2004, 31, 695–710. [Google Scholar] [CrossRef]
  225. Bollongino, R.; Burger, J.; Powell, A.; Mashkour, M.; Vigne, J.-D.; Thomas, M.G. Modern Taurine Cattle Descended from Small Number of near-Eastern Founders. Mol. Biol. Evol. 2012, 29, 2101–2104. [Google Scholar] [CrossRef] [PubMed]
  226. Colominas, L.; Schlumbaum, A.; Saña, M. The Impact of the Roman Empire on Animal Husbandry Practices: Study of the Changes in Cattle Morphology in the North-East of the Iberian Peninsula through Osteometric and Ancient DNA Analyses. Archaeol. Anthropol. Sci. 2014, 6, 1–16. [Google Scholar] [CrossRef]
  227. Niemi, M.; Bläuer, A.; Iso-Touru, T.; Harjula, J.; Nyström Edmark, V.; Rannamäe, E.; Lõugas, L.; Sajantila, A.; Lidén, K.; Taavitsainen, J.-P. Temporal Fluctuation in North East Baltic Sea Region Cattle Population Revealed by Mitochondrial and Y-Chromosomal DNA Analyses. PLoS ONE 2015, 10, e0123821. [Google Scholar]
  228. Meiri, M.; Stockhammer, P.W.; Marom, N.; Bar-Oz, G.; Sapir-Hen, L.; Morgenstern, P.; Macheridis, S.; Rosen, B.; Huchon, D.; Maran, J.; et al. Eastern Mediterranean Mobility in the Bronze and Early Iron Ages: Inferences from Ancient DNA of Pigs and Cattle. Sci. Rep. 2017, 7, 701. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  229. Chen, N.; Cai, Y.; Chen, Q.; Li, R.; Wang, K.; Huang, Y.; Hu, S.; Huang, S.; Zhang, H.; Zheng, Z.; et al. Whole-Genome Resequencing Reveals World-Wide Ancestry and Adaptive Introgression Events of Domesticated Cattle in East Asia. Nat. Commun. 2018, 9, 2337. [Google Scholar] [CrossRef]
  230. Balasse, M.; Gillis, R.; Živaljević, I.; Berthon, R.; Kovačiková, L.; Fiorillo, D.; Arbogast, R.-M.; Bălăşescu, A.; Bréhard, S.; Nyerges, É.Á.; et al. Seasonal Calving in European Prehistoric Cattle and Its Impacts on Milk Availability and Cheese-Making. Sci. Rep. 2021, 11, 8185. [Google Scholar] [CrossRef] [PubMed]
  231. Pitt, D.; Sevane, N.; Nicolazzi, E.L.; MacHugh, D.E.; Park, S.D.E.; Colli, L.; Martinez, R.; Bruford, M.W.; Orozco-terWengel, P. Domestication of Cattle: Two or Three Events? Evol. Appl. 2019, 12, 123–136. [Google Scholar] [CrossRef] [PubMed]
  232. Caramelli, D. The Origins of Domesticated Cattle. Hum. Evol. 2006, 21, 107–122. [Google Scholar] [CrossRef]
  233. Van Vuure, C.; van Vuure, T. Retracing the Aurochs: History, Morphology and Ecology of an Extinct Wild Ox; Pensoft Pub: Sofia, Bulgaria, 2005. [Google Scholar]
  234. Zhang, H.; Paijmans, J.L.A.; Chang, F.; Wu, X.; Chen, G.; Lei, C.; Yang, X.; Wei, Z.; Bradley, D.G.; Orlando, L.; et al. Morphological and Genetic Evidence for Early Holocene Cattle Management in Northeastern China. Nat. Commun. 2013, 4, 2755. [Google Scholar] [CrossRef] [Green Version]
  235. Cai, D.; Sun, Y.; Tang, Z.; Hu, S.; Li, W.; Zhao, X.; Xiang, H.; Zhou, H. The Origins of Chinese Domestic Cattle as Revealed by Ancient DNA Analysis. J. Archaeol. Sci. 2014, 41, 423–434. [Google Scholar] [CrossRef]
  236. Chen, S.; Lin, B.-Z.; Baig, M.; Mitra, B.; Lopes, R.J.; Santos, A.M.; Magee, D.A.; Azevedo, M.; Tarroso, P.; Sasazaki, S.; et al. Zebu Cattle Are an Exclusive Legacy of the South Asia Neolithic. Mol. Biol. Evol. 2010, 27, 1–6. [Google Scholar] [CrossRef] [Green Version]
  237. Lei, C.Z.; Chen, H.; Zhang, H.C.; Cai, X.; Liu, R.Y.; Luo, L.Y.; Wang, C.F.; Zhang, W.; Ge, Q.L.; Zhang, R.F.; et al. Origin and Phylogeographical Structure of Chinese Cattle. Anim. Genet. 2006, 37, 579–582. [Google Scholar] [CrossRef]
  238. Hristov, P.; Spassov, N.; Iliev, N.; Radoslavov, G. An Independent Event of Neolithic Cattle Domestication on the South-Eastern Balkans: Evidence from Prehistoric Aurochs and Cattle Populations. Mitochondrial DNA A DNA Mapp. Seq. Anal. 2017, 28, 383–391. [Google Scholar] [CrossRef]
  239. Verdugo, M.P.; Mullin, V.E.; Scheu, A.; Mattiangeli, V.; Daly, K.G.; Maisano Delser, P.; Hare, A.J.; Burger, J.; Collins, M.J.; Kehati, R.; et al. Ancient Cattle Genomics, Origins, and Rapid Turnover in the Fertile Crescent. Science 2019, 365, 173–176. [Google Scholar]
  240. Dai, L.; Balasse, M.; Yuan, J.; Zhao, C.; Hu, Y.; Vigne, J.-D. Cattle and Sheep Raising and Millet Growing in the Longshan Age in Central China: Stable Isotope Investigation at the Xinzhai Site. Quat. Int. 2016, 426, 145–157. [Google Scholar] [CrossRef]
  241. Berthon, R.; Kovačiková, L.; Tresset, A.; Balasse, M. Integration of Linearbandkeramik Cattle Husbandry in the Forested Landscape of the Mid-Holocene Climate Optimum: Seasonal-Scale Investigations in Bohemia. J. Anthropol. Archaeol. 2018, 51, 16–27. [Google Scholar] [CrossRef]
  242. Towers, J.; Gledhill, A.; Bond, J.; Montgomery, J. An Investigation of Cattle Birth Seasonality Using δ 13 C and δ 18 O Profiles within First Molar Enamel. Archaeometry 2014, 56, 208–236. [Google Scholar] [CrossRef] [Green Version]
  243. Gron, K.J.; Montgomery, J.; Rowley-Conwy, P. Cattle Management for Dairying in Scandinavia’s Earliest Neolithic. PLoS ONE 2015, 10, e0131267. [Google Scholar] [CrossRef] [Green Version]
  244. Fraser, S.; Elsner, J.; Derek Hamilton, W.; Sayle, K.L.; Schlumbaum, A.; Bartosiewicz, L. Matrilines in Neolithic Cattle from Orkney, Scotland Reveals Complex Husbandry Patterns of Ancestry. J. Archaeol. Sci. Rep. 2017, 14, 46–54. [Google Scholar] [CrossRef] [Green Version]
  245. Frantz, L.; Meijaard, E.; Gongora, J.; Haile, J.; Groenen, M.A.M.; Larson, G. The Evolution of Suidae. Annu. Rev. Anim. Biosci. 2016, 4, 61–85. [Google Scholar] [CrossRef] [Green Version]
  246. Larson, G.; Dobney, K.; Albarella, U.; Fang, M.; Matisoo-Smith, E.; Robins, J.; Lowden, S.; Finlayson, H.; Brand, T.; Willerslev, E.; et al. Worldwide Phylogeography of Wild Boar Reveals Multiple Centers of Pig Domestication. Science 2005, 307, 1618–1621. [Google Scholar] [CrossRef] [Green Version]
  247. Ervynck, A.; Dobney, K.; Hongo, H.; Meadow, R. Born Free? New Evidence for the Status of Sus Scrofa at Neolithic Çayönü Tepesi (Southeastern Anatolia, Turkey). Paléorient 2001, 27, 47–73. [Google Scholar] [CrossRef]
  248. Cucchi, T.; Hulme-Beaman, A.; Yuan, J.; Dobney, K. Early Neolithic Pig Domestication at Jiahu, Henan Province, China: Clues from Molar Shape Analyses Using Geometric Morphometric Approaches. J. Archaeol. Sci. 2011, 38, 11–22. [Google Scholar] [CrossRef]
  249. Groenen, M.A.M.; Archibald, A.L.; Uenishi, H.; Tuggle, C.K.; Takeuchi, Y.; Rothschild, M.F.; Rogel-Gaillard, C.; Park, C.; Milan, D.; Megens, H.-J.; et al. Analyses of Pig Genomes Provide Insight into Porcine Demography and Evolution. Nature 2012, 491, 393–398. [Google Scholar] [CrossRef] [PubMed]
  250. Frantz, L.A.F.; Schraiber, J.G.; Madsen, O.; Megens, H.-J.; Bosse, M.; Paudel, Y.; Semiadi, G.; Meijaard, E.; Li, N.; Crooijmans, R.P.M.A.; et al. Genome Sequencing Reveals Fine Scale Diversification and Reticulation History during Speciation in Sus. Genome Biol. 2013, 14, R107. [Google Scholar] [CrossRef] [Green Version]
  251. Larson, G.; Fuller, D.Q. The Evolution of Animal Domestication. Annu. Rev. Ecol. Evol. Systain. 2014, 45, 115–136. [Google Scholar] [CrossRef] [Green Version]
  252. Zeder, M.A. Others Pathways to Animal Domestication. Biodivers. Agric. Domest. Evol. Sustain. 2012, 227–259. [Google Scholar]
  253. Larson, G.; Liu, R.; Zhao, X.; Yuan, J.; Fuller, D.; Barton, L.; Dobney, K.; Fan, Q.; Gu, Z.; Liu, X.-H.; et al. Patterns of East Asian Pig Domestication, Migration, and Turnover Revealed by Modern and Ancient DNA. Proc. Natl. Acad. Sci. USA 2010, 107, 7686–7691. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  254. Megens, H.-J.; Crooijmans, R.P.M.A.; San Cristobal, M.; Hui, X.; Li, N.; Groenen, M.A.M. Biodiversity of Pig Breeds from China and Europe Estimated from Pooled DNA Samples: Differences in Microsatellite Variation between Two Areas of Domestication. Genet. Sel. Evol. 2008, 40, 103–128. [Google Scholar]
  255. Frantz, L.A.F.; Schraiber, J.G.; Madsen, O.; Megens, H.-J.; Cagan, A.; Bosse, M.; Paudel, Y.; Crooijmans, R.P.M.A.; Larson, G.; Groenen, M.A.M. Evidence of Long-Term Gene Flow and Selection during Domestication from Analyses of Eurasian Wild and Domestic Pig Genomes. Nat. Genet. 2015, 47, 1141–1148. [Google Scholar] [CrossRef] [PubMed]
  256. Rowley-Conwy, P.; Albarella, U.; Dobney, K. Distinguishing Wild Boar from Domestic Pigs in Prehistory: A Review of Approaches and Recent Results. J. World Prehistory 2012, 25, 1–44. [Google Scholar] [CrossRef]
  257. Evin, A.; Cucchi, T.; Cardini, A.; Strand Vidarsdottir, U.; Larson, G.; Dobney, K. The Long and Winding Road: Identifying Pig Domestication through Molar Size and Shape. J. Archaeol. Sci. 2013, 40, 735–743. [Google Scholar] [CrossRef]
  258. Khederzadeh, S.; Kusza, S.; Huang, C.-P.; Markov, N.; Scandura, M.; Babaev, E.; Šprem, N.; Seryodkin, I.V.; Paule, L.; Esmailizadeh, A.; et al. Maternal Genomic Variability of the Wild Boar (Sus Scrofa) Reveals the Uniqueness of East-Caucasian and Central Italian Populations. Ecol. Evol. 2019, 9, 9467–9478. [Google Scholar] [CrossRef] [Green Version]
  259. Ni, P.; Bhuiyan, A.A.; Chen, J.-H.; Li, J.; Zhang, C.; Zhao, S.; Du, X.; Li, H.; Yu, H.; Liu, X.; et al. De Novo Assembly of Mitochondrial Genomes Provides Insights into Genetic Diversity and Molecular Evolution in Wild Boars and Domestic Pigs. Genetica 2018, 146, 277–285. [Google Scholar] [CrossRef] [PubMed]
  260. Zhao, P.; Du, H.; Jiang, L.; Zheng, X.; Feng, W.; Diao, C.; Zhou, L.; Liu, G.E.; Zhang, H.; Chamba, Y.; et al. PRE-1 Revealed Previous Unknown Introgression Events in Eurasian Boars during the Middle Pleistocene. Genome Biol. Evol. 2020, 12, 1751–1764. [Google Scholar] [CrossRef]
  261. Adeola, A.C.; Oluwole, O.O.; Oladele, B.M.; Olorungbounmi, T.O.; Boladuro, B.; Olaogun, S.C.; Nneji, L.M.; Sanke, O.J.; Dawuda, P.M.; Omitogun, O.G.; et al. Analysis of the Genetic Variation in Mitochondrial DNA, Y-Chromosome Sequences, and MC1R Sheds Light on the Ancestry of Nigerian Indigenous Pigs. Genet. Sel. Evol. 2017, 49, 52. [Google Scholar] [CrossRef]
  262. Larson, G.; Albarella, U.; Dobney, K.; Rowley-Conwy, P.; Schibler, J.; Tresset, A.; Vigne, J.-D.; Edwards, C.J.; Schlumbaum, A.; Dinu, A.; et al. Ancient DNA, Pig Domestication, and the Spread of the Neolithic into Europe. Proc. Natl. Acad. Sci. USA 2007, 104, 15276–15281. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  263. Krause-Kyora, B.; Makarewicz, C.; Evin, A.; Flink, L.G.; Dobney, K.; Larson, G.; Hartz, S.; Schreiber, S.; von Carnap-Bornheim, C.; von Wurmb-Schwark, N.; et al. Use of Domesticated Pigs by Mesolithic Hunter-Gatherers in Northwestern Europe. Nat. Commun. 2013, 4, 2348. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  264. Ottoni, C.; Flink, L.G.; Evin, A.; Geörg, C.; De Cupere, B.; Van Neer, W.; Bartosiewicz, L.; Linderholm, A.; Barnett, R.; Peters, J.; et al. Pig Domestication and Human-Mediated Dispersal in Western Eurasia Revealed through Ancient DNA and Geometric Morphometrics. Mol. Biol. Evol. 2013, 30, 824–832. [Google Scholar] [CrossRef] [Green Version]
  265. Caliebe, A.; Nebel, A.; Makarewicz, C.; Krawczak, M.; Krause-Kyora, B. Insights into Early Pig Domestication Provided by Ancient DNA Analysis. Sci. Rep. 2017, 7, 44550. [Google Scholar] [CrossRef] [PubMed]
  266. Vai, S.; Vilaça, S.T.; Romandini, M.; Benazzo, A.; Visentini, P.; Modolo, M.; Bertolini, M.; MacQueen, P.; Austin, J.; Cooper, A.; et al. The Biarzo Case in Northern Italy: Is the Temporal Dynamic of Swine Mitochondrial DNA Lineages in Europe Related to Domestication? Sci. Rep. 2015, 5, 16514. [Google Scholar] [CrossRef] [Green Version]
  267. Hammer, S.E.; Tautscher, B.; Pucher, E.; Kowarik, K.; Reschreiter, H.; Kern, A.; Haring, E. Bronze Age Meat Industry: Ancient Mitochondrial DNA Analyses of Pig Bones from the Prehistoric Salt Mines of Hallstatt (Austria). BMC Res. Notes 2018, 11, 243. [Google Scholar] [CrossRef] [Green Version]
  268. Evin, A.; Flink, L.G.; Bălăşescu, A.; Popovici, D.; Andreescu, R.; Bailey, D.; Mirea, P.; Lazăr, C.; Boroneanţ, A.; Bonsall, C.; et al. Unravelling the Complexity of Domestication: A Case Study Using Morphometrics and Ancient DNA Analyses of Archaeological Pigs from Romania. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2015, 370, 20130616. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  269. Larson, G.; Cucchi, T.; Fujita, M.; Matisoo-Smith, E.; Robins, J.; Anderson, A.; Rolett, B.; Spriggs, M.; Dolman, G.; Kim, T.-H.; et al. Phylogeny and Ancient DNA of Sus Provides Insights into Neolithic Expansion in Island Southeast Asia and Oceania. Proc. Natl. Acad. Sci. USA 2007, 104, 4834–4839. [Google Scholar] [CrossRef] [Green Version]
  270. Frantz, L.A.F.; Haile, J.; Lin, A.T.; Scheu, A.; Geörg, C.; Benecke, N.; Alexander, M.; Linderholm, A.; Mullin, V.E.; Daly, K.G.; et al. Ancient Pigs Reveal a near-Complete Genomic Turnover Following Their Introduction to Europe. Proc. Natl. Acad. Sci. USA 2019, 116, 17231–17238. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  271. Balasse, M.; Cucchi, T.; Evin, A.; Bălăşescu, A.; Frémondeau, D.; Horard-Herbin, M.-P. Wild game or farm animal? Tracking human-pig relationships in ancient times through stable isotope analysis. In Hybrid Communities; Routledge: London, UK, 2018; Volume 1, pp. 81–96. [Google Scholar]
  272. Minagawa, M.; Matsui, A.; Ishiguro, N. Patterns of Prehistoric Boar Sus Scrofa Domestication, and Inter-Islands Pig Trading across the East China Sea, as Determined by Carbon and Nitrogen Isotope Analysis. Chem. Geol. 2005, 218, 91–102. [Google Scholar] [CrossRef]
  273. Lösch, S.; Grupe, G.; Peters, J. Stable Isotopes and Dietary Adaptations in Humans and Animals at Pre-Pottery Neolithic Nevalli Cori, Southeast Anatolia. Am. J. Phys. Anthropol. 2006, 131, 181–193. [Google Scholar] [CrossRef] [PubMed]
  274. Dai, L.; Kan, X.; Zhang, X. An Investigation into the Strategy of Pig Husbandry Combining Zooarchaeological and Stable Isotopic Approaches at Neolithic Houjiazhai, China. Int. J. Osteoarchaeol. 2019, 29, 772–785. [Google Scholar] [CrossRef]
  275. Madgwick, R.; Mulville, J.; Stevens, R.E. Diversity in Foddering Strategy and Herd Management in Late Bronze Age Britain: An Isotopic Investigation of Pigs and Other Fauna from Two Midden Sites. Environ. Archaeol. 2012, 17, 126–140. [Google Scholar] [CrossRef]
  276. Hamilton, J.; Thomas, R. Pannage, Pulses and Pigs: Isotopic and Zooarchaeological Evidence for Changing Pig Management Practices in Later Medieval England. Mediev. Archaeol. 2012, 56, 234–259. [Google Scholar] [CrossRef]
  277. Müldner, G.; Richards, M.P. Stable Isotope Evidence for 1500 Years of Human Diet at the City of York, UK. Am. J. Phys. Anthropol. 2007, 133, 682–697. [Google Scholar] [CrossRef] [PubMed]
  278. Hu, Y.; Luan, F.; Wang, S.; Wang, C.; Richards, M.P. Preliminary Attempt to Distinguish the Domesticated Pigs from Wild Boars by the Methods of Carbon and Nitrogen Stable Isotope Analysis. Sci. China Ser. D Earth Sci. 2009, 52, 85–92. [Google Scholar] [CrossRef] [Green Version]
  279. Pechenkina, E.A.; Ambrose, S.H.; Xiaolin, M.; Benfer, R.A. Reconstructing Northern Chinese Neolithic Subsistence Practices by Isotopic Analysis. J. Archaeol. Sci. 2005, 32, 1176–1189. [Google Scholar] [CrossRef]
  280. Wang, X.; Fuller, B.T.; Zhang, P.; Hu, S.; Hu, Y.; Shang, X. Millet Manuring as a Driving Force for the Late Neolithic Agricultural Expansion of North China. Sci. Rep. 2018, 8, 5552. [Google Scholar] [CrossRef]
  281. Fenner, J.N.; Gagan, M.K.; Cowley, J.; Armstrong, R.; Prasetyo, B. Investigating the Presence of Foreigners and Pig Husbandry in Ancient Bali: Stable Isotopes in Human and Domestic Animal Tooth Enamel. J. Archaeol. Sci. Rep. 2016, 10, 272–281. [Google Scholar] [CrossRef]
  282. Orlando, L. Ancient Genomes Reveal Unexpected Horse Domestication and Management Dynamics. Bioessays 2020, 42, e1900164. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  283. Orlando, L.; Ginolhac, A.; Raghavan, M.; Vilstrup, J.; Rasmussen, M.; Magnussen, K.; Steinmann, K.E.; Kapranov, P.; Thompson, J.F.; Zazula, G.; et al. True Single-Molecule DNA Sequencing of a Pleistocene Horse Bone. Genome Res. 2011, 21, 1705–1719. [Google Scholar] [CrossRef] [Green Version]
  284. Orlando, L.; Ginolhac, A.; Zhang, G.; Froese, D.; Albrechtsen, A.; Stiller, M.; Schubert, M.; Cappellini, E.; Petersen, B.; Moltke, I.; et al. Recalibrating Equus Evolution Using the Genome Sequence of an Early Middle Pleistocene Horse. Nature 2013, 499, 74–78. [Google Scholar] [CrossRef] [PubMed]
  285. Leonardi, M.; Boschin, F.; Giampoudakis, K.; Beyer, R.M.; Krapp, M.; Bendrey, R.; Sommer, R.; Boscato, P.; Manica, A.; Nogues-Bravo, D.; et al. Late Quaternary Horses in Eurasia in the Face of Climate and Vegetation Change. Sci. Adv. 2018, 4, eaar5589. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  286. Vershinina, A.O.; Heintzman, P.D.; Froese, D.G.; Zazula, G.; Cassatt-Johnstone, M.; Dalén, L.; Der Sarkissian, C.; Dunn, S.G.; Ermini, L.; Gamba, C.; et al. Ancient Horse Genomes Reveal the Timing and Extent of Dispersals across the Bering Land Bridge. Mol. Ecol. 2021. [Google Scholar] [CrossRef]
  287. Frantz, L.A.F.; Bradley, D.G.; Larson, G.; Orlando, L. Animal Domestication in the Era of Ancient Genomics. Nat. Rev. Genet. 2020, 21, 449–460. [Google Scholar] [CrossRef]
  288. Gaunitz, C.; Fages, A.; Hanghøj, K.; Albrechtsen, A.; Khan, N.; Schubert, M.; Seguin-Orlando, A.; Owens, I.J.; Felkel, S.; Bignon-Lau, O.; et al. Ancient Genomes Revisit the Ancestry of Domestic and Przewalski’s Horses. Science 2018, 360, 111–114. [Google Scholar] [CrossRef] [Green Version]
  289. Schubert, M.; Jónsson, H.; Chang, D.; Der Sarkissian, C.; Ermini, L.; Ginolhac, A.; Albrechtsen, A.; Dupanloup, I.; Foucal, A.; Petersen, B.; et al. Prehistoric Genomes Reveal the Genetic Foundation and Cost of Horse Domestication. Proc. Natl. Acad. Sci. USA 2014, 111, E5661–E5669. [Google Scholar] [CrossRef] [Green Version]
  290. Warmuth, V.; Eriksson, A.; Bower, M.A.; Barker, G.; Barrett, E.; Hanks, B.K.; Li, S.; Lomitashvili, D.; Ochir-Goryaeva, M.; Sizonov, G.V.; et al. Reconstructing the Origin and Spread of Horse Domestication in the Eurasian Steppe. Proc. Natl. Acad. Sci. USA 2012, 109, 8202–8206. [Google Scholar] [CrossRef] [Green Version]
  291. Cieslak, M.; Pruvost, M.; Benecke, N.; Hofreiter, M.; Morales, A.; Reissmann, M.; Ludwig, A. Origin and History of Mitochondrial DNA Lineages in Domestic Horses. PLoS ONE 2010, 5, e15311. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  292. Fages, A.; Hanghøj, K.; Khan, N.; Gaunitz, C.; Seguin-Orlando, A.; Leonardi, M.; McCrory Constantz, C.; Gamba, C.; Al-Rasheid, K.A.S.; Albizuri, S.; et al. Tracking Five Millennia of Horse Management with Extensive Ancient Genome Time Series. Cell 2019, 177, 1419–1435. [Google Scholar] [CrossRef]
  293. Kooyman, B.; Newman, M.E.; Cluney, C.; Lobb, M.; Tolman, S.; McNeil, P.; Hills, L.V. Identification of Horse Exploitation by Clovis Hunters Based on Protein Analysis. Am. Antiq. 2001, 66, 686–691. [Google Scholar] [CrossRef]
  294. Librado, P.; Gamba, C.; Gaunitz, C.; Der Sarkissian, C.; Pruvost, M.; Albrechtsen, A.; Fages, A.; Khan, N.; Schubert, M.; Jagannathan, V.; et al. Ancient Genomic Changes Associated with Domestication of the Horse. Science 2017, 356, 442–445. [Google Scholar] [CrossRef]
  295. Wallner, B.; Palmieri, N.; Vogl, C.; Rigler, D.; Bozlak, E.; Druml, T.; Jagannathan, V.; Leeb, T.; Fries, R.; Tetens, J.; et al. Y Chromosome Uncovers the Recent Oriental Origin of Modern Stallions. Curr. Biol. 2017, 27, 2029–2035.e5. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  296. Lippold, S.; Knapp, M.; Kuznetsova, T.; Leonard, J.A.; Benecke, N.; Ludwig, A.; Rasmussen, M.; Cooper, A.; Weinstock, J.; Willerslev, E.; et al. Discovery of Lost Diversity of Paternal Horse Lineages Using Ancient DNA. Nat. Commun. 2011, 2, 450. [Google Scholar] [CrossRef] [PubMed]
  297. Prado, J.L.; Sánchez, B.; Alberdi, M.T. Ancient Feeding Ecology Inferred from Stable Isotopic Evidence from Fossil Horses in South America over the Past 3 Ma. BMC Ecol. 2011, 11, 15. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  298. Miller, A.R.V.; Ventresca Miller, A.R.; Bragina, T.M.; Abil, Y.A.; Rulyova, M.M.; Makarewicz, C.A. Correction to: Pasture Usage by Ancient Pastoralists in the Northern Kazakh Steppe Informed by Carbon and Nitrogen Isoscapes of Contemporary Floral Biomes. Archaeol. Anthropol. Sci. 2019, 11, 3063–3064. [Google Scholar] [CrossRef] [Green Version]
  299. Kaczensky, P.; Šturm, M.B.; Sablin, M.V.; Voigt, C.C.; Smith, S.; Ganbaatar, O.; Balint, B.; Walzer, C.; Spasskaya, N.N. Stable Isotopes Reveal Diet Shift from Pre-Extinction to Reintroduced Przewalski’s Horses. Sci. Rep. 2017, 7, 5950. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  300. Baca, M.; Popović, D.; Panagiotopoulou, H.; Marciszak, A.; Krajcarz, M.; Krajcarz, M.T.; Makowiecki, D.; Węgleński, P.; Nadachowski, A. Human-Mediated Dispersal of Cats in the Neolithic Central Europe. Heredity 2018, 121, 557–563. [Google Scholar] [CrossRef] [Green Version]
  301. Randi, E.; Pierpaoli, M.; Beaumont, M.; Ragni, B.; Sforzi, A. Genetic Identification of Wild and Domestic Cats (Felis Silvestris) and Their Hybrids Using Bayesian Clustering Methods. Mol. Biol. Evol. 2001, 18, 1679–1693. [Google Scholar] [CrossRef] [Green Version]
  302. Driscoll, C.A.; Menotti-Raymond, M.; Roca, A.L.; Hupe, K.; Johnson, W.E.; Geffen, E.; Harley, E.H.; Delibes, M.; Pontier, D.; Kitchener, A.C.; et al. The Near Eastern Origin of Cat Domestication. Science 2007, 317, 519–523. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  303. Driscoll, C.A.; Macdonald, D.W.; O’Brien, S.J. From Wild Animals to Domestic Pets, an Evolutionary View of Domestication. Proc. Natl. Acad. Sci. USA 2009, 106 (Suppl. S1), 9971–9978. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  304. Ottoni, C.; Van Neer, W.; De Cupere, B.; Daligault, J.; Guimaraes, S.; Peters, J.; Spassov, N.; Prendergast, M.E.; Boivin, N.; Morales-Muñiz, A.; et al. The Palaeogenetics of Cat Dispersal in the Ancient World. Nat. Ecol. Evol. 2017, 1, 139. [Google Scholar] [CrossRef]
  305. Hu, Y.; Hu, S.; Wang, W.; Wu, X.; Marshall, F.B.; Chen, X.; Hou, L.; Wang, C. Earliest Evidence for Commensal Processes of Cat Domestication. Proc. Natl. Acad. Sci. USA 2014, 111, 116–120. [Google Scholar] [CrossRef] [Green Version]
  306. Krajcarz, M.; Krajcarz, M.T.; Baca, M.; Baumann, C.; Van Neer, W.; Popović, D.; Sudoł-Procyk, M.; Wach, B.; Wilczyński, J.; Wojenka, M.; et al. Ancestors of Domestic Cats in Neolithic Central Europe: Isotopic Evidence of a Synanthropic Diet. Proc. Natl. Acad. Sci. USA 2020, 117, 17710–17719. [Google Scholar] [CrossRef] [PubMed]
  307. Vigne, J.-D.; Guilaine, J.; Debue, K.; Haye, L.; Gérard, P. Early Taming of the Cat in Cyprus. Science 2004, 304, 259. [Google Scholar] [CrossRef] [Green Version]
  308. Krajcarz, M.; Makowiecki, D.; Krajcarz, M.T.; Masłowska, A.; Baca, M.; Panagiotopoulou, H.; Romańska, A.; Bednarczyk, J.; Gręzak, A.; Sudoł, M. On the Trail of the Oldest Domestic Cat in Poland. An Insight from Morphometry, Ancient DNA and Radiocarbon Dating. Int. J. Osteoarchaeol. 2016, 26, 912–919. [Google Scholar] [CrossRef]
  309. Guiry, E.J.; Orchard, T.J.; Royle, T.C.A.; Cheung, C.; Yang, D.Y. Dietary Plasticity and the Extinction of the Passenger Pigeon (Ectopistes Migratorius). Quat. Sci. Rev. 2020, 233, 106225. [Google Scholar] [CrossRef]
  310. Rawlence, N.J.; Metcalf, J.L.; Wood, J.R.; Worthy, T.H.; Austin, J.J.; Cooper, A. The Effect of Climate and Environmental Change on the Megafaunal Moa of New Zealand in the Absence of Humans. Quat. Sci. Rev. 2012, 50, 141–153. [Google Scholar] [CrossRef]
Figure 1. Biomolecular studies within a spatio-temporal context. (a) Global distribution map with the various types of biomolecular and biogeochemical analyses plotted, with inset showing studies in Europe; (b) bar plot showing the number of studies included per country and continent; (c) bar plot showing the number of studies included per taxon; and (d) bar plot showing major temporal stratigraphic divisions (http://quaternary.stratigraphy.org (accessed on 7 May 2021)) represented in the studies. Note that the number of studies included does not refer to unique studies as some studies included multiple taxa, geographic locations and time periods.
Figure 1. Biomolecular studies within a spatio-temporal context. (a) Global distribution map with the various types of biomolecular and biogeochemical analyses plotted, with inset showing studies in Europe; (b) bar plot showing the number of studies included per country and continent; (c) bar plot showing the number of studies included per taxon; and (d) bar plot showing major temporal stratigraphic divisions (http://quaternary.stratigraphy.org (accessed on 7 May 2021)) represented in the studies. Note that the number of studies included does not refer to unique studies as some studies included multiple taxa, geographic locations and time periods.
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Figure 2. Timelines of taxa in a palaeoenvironmental context. Timelines outlining important evolutionary events in the selected taxa in relation to environmental events and the expansion of anatomically modern humans. Climate variability is represented over the past 150 thousand years (ka) including (synthetic) oxygen isotope record from Greenland ice cores [84,85], seawater oxygen isotope record (Uvigerina δ18O) [86], and global benthic oxygen isotope stack [87] proxies for global ice volume and relative sea-level [88]. LGM refers to the Last Glacial Maximum, TI-TII represent glacial terminations according to [85], cold events represent Heinrich stadials associated with ice-rafting events of the last climatic cycle (H1-H6, C19-C24) [89,90], and selected volcanic eruptions are represented according to [91]. For the sake of clarity, given that the high number of studies included in our review and the vast majority of events studied relate to the Northern Hemisphere, we present reconstructions for the Northern Hemisphere only.
Figure 2. Timelines of taxa in a palaeoenvironmental context. Timelines outlining important evolutionary events in the selected taxa in relation to environmental events and the expansion of anatomically modern humans. Climate variability is represented over the past 150 thousand years (ka) including (synthetic) oxygen isotope record from Greenland ice cores [84,85], seawater oxygen isotope record (Uvigerina δ18O) [86], and global benthic oxygen isotope stack [87] proxies for global ice volume and relative sea-level [88]. LGM refers to the Last Glacial Maximum, TI-TII represent glacial terminations according to [85], cold events represent Heinrich stadials associated with ice-rafting events of the last climatic cycle (H1-H6, C19-C24) [89,90], and selected volcanic eruptions are represented according to [91]. For the sake of clarity, given that the high number of studies included in our review and the vast majority of events studied relate to the Northern Hemisphere, we present reconstructions for the Northern Hemisphere only.
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Figure 3. Biomolecular studies on wild taxa. Global distribution map with the various types of biomolecular and biogeochemical analyses plotted separately for cave bear, woolly mammoth, woolly rhinoceros, and bison. Note that the number of studies included does not refer to unique studies as some studies included multiple geographic locations.
Figure 3. Biomolecular studies on wild taxa. Global distribution map with the various types of biomolecular and biogeochemical analyses plotted separately for cave bear, woolly mammoth, woolly rhinoceros, and bison. Note that the number of studies included does not refer to unique studies as some studies included multiple geographic locations.
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Figure 4. Biomolecular studies on domestic taxa. Global distribution map with the various types of biomolecular and biogeochemical analyses plotted separately for dog, sheep, cattle, pig, horse, and cat. Note that the number of studies included does not refer to unique studies as some studies included multiple geographic locations.
Figure 4. Biomolecular studies on domestic taxa. Global distribution map with the various types of biomolecular and biogeochemical analyses plotted separately for dog, sheep, cattle, pig, horse, and cat. Note that the number of studies included does not refer to unique studies as some studies included multiple geographic locations.
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Figure 5. Diachronic trends in biomolecular studies. Bar plot with the number of studies published per year.
Figure 5. Diachronic trends in biomolecular studies. Bar plot with the number of studies published per year.
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Rosengren, E.; Acatrinei, A.; Cruceru, N.; Dehasque, M.; Haliuc, A.; Lord, E.; Mircea, C.I.; Rusu, I.; Mármol-Sánchez, E.; Kelemen, B.S.; et al. Ancient Faunal History Revealed by Interdisciplinary Biomolecular Approaches. Diversity 2021, 13, 370. https://0-doi-org.brum.beds.ac.uk/10.3390/d13080370

AMA Style

Rosengren E, Acatrinei A, Cruceru N, Dehasque M, Haliuc A, Lord E, Mircea CI, Rusu I, Mármol-Sánchez E, Kelemen BS, et al. Ancient Faunal History Revealed by Interdisciplinary Biomolecular Approaches. Diversity. 2021; 13(8):370. https://0-doi-org.brum.beds.ac.uk/10.3390/d13080370

Chicago/Turabian Style

Rosengren, Erika, Arina Acatrinei, Nicolae Cruceru, Marianne Dehasque, Aritina Haliuc, Edana Lord, Cristina I. Mircea, Ioana Rusu, Emilio Mármol-Sánchez, Beatrice S. Kelemen, and et al. 2021. "Ancient Faunal History Revealed by Interdisciplinary Biomolecular Approaches" Diversity 13, no. 8: 370. https://0-doi-org.brum.beds.ac.uk/10.3390/d13080370

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