Next Article in Journal
1,2-Dihydroxyxanthone: Effect on A375-C5 Melanoma Cell Growth Associated with Interference with THP-1 Human Macrophage Activity
Next Article in Special Issue
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells
Previous Article in Journal
Voltammetric Evaluation of Diclofenac Tablets Samples through Carbon Black-Based Electrodes
Previous Article in Special Issue
Strategies for the Development of Glycomimetic Drug Candidates

Developments in Carbohydrate-Based Cancer Therapeutics

Department of Chemistry and Biochemistry, University of Toledo, Toledo, OH 43606, USA
Author to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(2), 84;
Received: 3 May 2019 / Revised: 24 May 2019 / Accepted: 29 May 2019 / Published: 4 June 2019
(This article belongs to the Special Issue Carbohydrates 2018)
Cancer cells of diverse origins express extracellular tumor-specific carbohydrate antigens (TACAs) because of aberrant glycosylation. Overexpressed TACAs on the surface of tumor cells are considered biomarkers for cancer detection and have always been prioritized for the development of novel carbohydrate-based anti-cancer vaccines. In recent years, progress has been made in developing synthetic, carbohydrate-based antitumor vaccines to improve immune responses associated with targeting these specific antigens. Tumor cells also exhaust more energy for proliferation than normal cells, by consuming excessive amounts of glucose via overexpressed sugar binding or transporting receptors located in the cellular membrane. Furthermore, inspired by the Warburg effect, glycoconjugation strategies of anticancer drugs have gained considerable attention from the scientific community. This review highlights a small cohort of recent efforts which have been made in carbohydrate-based cancer treatments, including vaccine design and the development of glycoconjugate prodrugs, glycosidase inhibiting iminosugars, and early cancer diagnosis. View Full-Text
Keywords: cancer treatment; carbohydrate antigens; carbohydrate-based antitumor vaccines; warburg effect; iminosugar; cancer diagnosis cancer treatment; carbohydrate antigens; carbohydrate-based antitumor vaccines; warburg effect; iminosugar; cancer diagnosis
Show Figures

Figure 1

MDPI and ACS Style

Hossain, F.; Andreana, P.R. Developments in Carbohydrate-Based Cancer Therapeutics. Pharmaceuticals 2019, 12, 84.

AMA Style

Hossain F, Andreana PR. Developments in Carbohydrate-Based Cancer Therapeutics. Pharmaceuticals. 2019; 12(2):84.

Chicago/Turabian Style

Hossain, Farzana, and Peter R. Andreana 2019. "Developments in Carbohydrate-Based Cancer Therapeutics" Pharmaceuticals 12, no. 2: 84.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop