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Neural Predictors of the Antidepressant Placebo Response

Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Author to whom correspondence should be addressed.
Both authors contributed equally.
Pharmaceuticals 2019, 12(4), 158;
Received: 30 September 2019 / Revised: 15 October 2019 / Accepted: 18 October 2019 / Published: 19 October 2019
(This article belongs to the Special Issue Antidepressants: Mechanistic Insights and Future Directions)
The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates. This manuscript reviews recent neuroimaging studies that aim to identify the neural signature of antidepressant placebo response. Data captured in clinical trials have primarily focused on antidepressant efficacy or predicting antidepressant response and have reliably implicated the rostral anterior cingulate cortex (rACC) in antidepressant placebo response, but also in medication response. Imaging and electroencephalography (EEG) experiments specifically interrogating the mechanism of antidepressant placebo response, while few, suggest the reward network, including opiate neurotransmission, is also involved. Therefore, while the rACC is likely involved in the antidepressant placebo response, its observation in isolation is unlikely to prospectively distinguish antidepressant placebo from medication responders. Instead, future studies of antidepressant placebo response should probe the reward network as a whole and incorporate sophisticated computational analytical approaches. View Full-Text
Keywords: placebo response; antidepressant; neural predictors placebo response; antidepressant; neural predictors
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MDPI and ACS Style

Rette, D.; McDonald, E.; Iosifescu, D.V.; Collins, K.A. Neural Predictors of the Antidepressant Placebo Response. Pharmaceuticals 2019, 12, 158.

AMA Style

Rette D, McDonald E, Iosifescu DV, Collins KA. Neural Predictors of the Antidepressant Placebo Response. Pharmaceuticals. 2019; 12(4):158.

Chicago/Turabian Style

Rette, Danielle, Erin McDonald, Dan V. Iosifescu, and Katherine A. Collins 2019. "Neural Predictors of the Antidepressant Placebo Response" Pharmaceuticals 12, no. 4: 158.

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