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Review

From Ethnomedicine to Plant Biotechnology and Machine Learning: The Valorization of the Medicinal Plant Bryophyllum sp.

1
Applied Plant & Soil Biology, Plant Biology and Soil Science Department, Biology Faculty, University of Vigo, E-36310 Vigo, Spain
2
CITACA—Agri-Food Research and Transfer Cluster, University of Vigo, E-32004 Ourense, Spain
3
Pharmacology, Pharmacy and Pharmaceutical Technology Department, Grupo I+D Farma (GI-1645), Pharmacy Faculty, University of Santiago, E-15782 Santiago de Compostela, Spain
4
Health Research Institute of Santiago de Compostela (IDIS), E-15782 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
Both authors contributed equally in this manuscript.
Pharmaceuticals 2020, 13(12), 444; https://0-doi-org.brum.beds.ac.uk/10.3390/ph13120444
Received: 10 November 2020 / Revised: 2 December 2020 / Accepted: 2 December 2020 / Published: 4 December 2020
(This article belongs to the Special Issue Medicinal Plants 2020)
The subgenus Bryophyllum includes about 25 plant species native to Madagascar, and is widely used in traditional medicine worldwide. Different formulations from Bryophyllum have been employed for the treatment of several ailments, including infections, gynecological disorders, and chronic diseases, such as diabetes, neurological and neoplastic diseases. Two major families of secondary metabolites have been reported as responsible for these bioactivities: phenolic compounds and bufadienolides. These compounds are found in limited amounts in plants because they are biosynthesized in response to different biotic and abiotic stresses. Therefore, novel approaches should be undertaken with the aim of achieving the phytochemical valorization of Bryophyllum sp., allowing a sustainable production that prevents from a massive exploitation of wild plant resources. This review focuses on the study of phytoconstituents reported on Bryophyllum sp.; the application of plant tissue culture methodology as a reliable tool for the valorization of bioactive compounds; and the application of machine learning technology to model and optimize the full phytochemical potential of Bryophyllum sp. As a result, Bryophyllum species can be considered as a promising source of plant bioactive compounds, with enormous antioxidant and anticancer potential, which could be used for their large-scale biotechnological exploitation in cosmetic, food, and pharmaceutical industries. View Full-Text
Keywords: Bryophyllum; traditional medicine; secondary metabolism; bioactive and phenolic compounds; bufadienolides; antioxidants; cytotoxic activity; plant tissue culture; artificial intelligence Bryophyllum; traditional medicine; secondary metabolism; bioactive and phenolic compounds; bufadienolides; antioxidants; cytotoxic activity; plant tissue culture; artificial intelligence
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MDPI and ACS Style

García-Pérez, P.; Lozano-Milo, E.; Landin, M.; Gallego, P.P. From Ethnomedicine to Plant Biotechnology and Machine Learning: The Valorization of the Medicinal Plant Bryophyllum sp. Pharmaceuticals 2020, 13, 444. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13120444

AMA Style

García-Pérez P, Lozano-Milo E, Landin M, Gallego PP. From Ethnomedicine to Plant Biotechnology and Machine Learning: The Valorization of the Medicinal Plant Bryophyllum sp. Pharmaceuticals. 2020; 13(12):444. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13120444

Chicago/Turabian Style

García-Pérez, Pascual, Eva Lozano-Milo, Mariana Landin, and Pedro P. Gallego 2020. "From Ethnomedicine to Plant Biotechnology and Machine Learning: The Valorization of the Medicinal Plant Bryophyllum sp." Pharmaceuticals 13, no. 12: 444. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13120444

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