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Article

A Pilot Study of a Natural Food Supplement as New Possible Therapeutic Approach in Chronic Kidney Disease Patients

1
UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
2
Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy
3
PHYTOLAB (Pharmaceutical, Cosmetic, Food Supplement, Technology and Analysis)-DiSIA, University of Florence, Via U. Schiff, 6, 50019 Sesto Fiorentino, Italy
4
School of Applied Medical, Surgical Sciences, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(7), 148; https://0-doi-org.brum.beds.ac.uk/10.3390/ph13070148
Received: 22 May 2020 / Revised: 30 June 2020 / Accepted: 7 July 2020 / Published: 10 July 2020
The identification of natural bioactive compounds, able to counteract the abnormal increase of oxidative stress and inflammatory status in chronic degenerative non-communicable diseases is useful for the clinical management of these conditions. We tested an oral food supplement (OFS), chemically characterized and evaluated for in vitro and in vivo activity. Vitamin C, analyzed by High Performance Liquid Chromatography-Diode Array Detector (HPLC-DAD), was 0.19 mg/g in rosehip dry extract and 15.74 mg/capsule in the OFS. The identification of polyphenols was performed by HPLC-DAD; the total antioxidant capacity was assessed by Folin–Ciocalteu test. Total polyphenols were 14.73 mg/g gallic acid equivalents (GAE) for rosehip extract and 1.93 mg/g GAE for OFS. A total of 21 chronic kidney disease (CKD) patients and 10 healthy volunteers were recruited. The evaluation of routine laboratory and inflammatory parameters, erythrocyte glutathione transferase (e-GST), human oxidized serum albumin (HSAox), and assessment of body composition were performed at two different times, at baseline and after 5 weeks of OFS assumption. In the study, we highlighted a significant decrease of traditional inflammatory biomarkers (such as C-reactive protein, erythrocyte sedimentation rate, platelet to lymphocyte ratio) and other laboratory parameters like e-GST, azotaemia, and albuminuria after OFS treatment in CKD patients. Moreover, we demonstrated a lipid profile improvement in CKD patients after OFS supplementation. View Full-Text
Keywords: inflammatory biomarkers; bioactive compounds; natural antioxidants; vitamin C; conservative therapy; erythrocyte glutathione transferase; human oxidized serum albumin inflammatory biomarkers; bioactive compounds; natural antioxidants; vitamin C; conservative therapy; erythrocyte glutathione transferase; human oxidized serum albumin
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MDPI and ACS Style

Noce, A.; Bocedi, A.; Campo, M.; Marrone, G.; Di Lauro, M.; Cattani, G.; Di Daniele, N.; Romani, A. A Pilot Study of a Natural Food Supplement as New Possible Therapeutic Approach in Chronic Kidney Disease Patients. Pharmaceuticals 2020, 13, 148. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13070148

AMA Style

Noce A, Bocedi A, Campo M, Marrone G, Di Lauro M, Cattani G, Di Daniele N, Romani A. A Pilot Study of a Natural Food Supplement as New Possible Therapeutic Approach in Chronic Kidney Disease Patients. Pharmaceuticals. 2020; 13(7):148. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13070148

Chicago/Turabian Style

Noce, Annalisa, Alessio Bocedi, Margherita Campo, Giulia Marrone, Manuela Di Lauro, Giada Cattani, Nicola Di Daniele, and Annalisa Romani. 2020. "A Pilot Study of a Natural Food Supplement as New Possible Therapeutic Approach in Chronic Kidney Disease Patients" Pharmaceuticals 13, no. 7: 148. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13070148

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