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Article

Reversal of Increase in Intestinal Permeability by Mangifera indica Seed Kernel Extract in High-Fat Diet-Induced Obese Mice

1
Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Hyderabad 500078, India
2
Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Hyderabad 500078, India
3
Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center, Bethesda, MD 20814, USA
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(8), 190; https://0-doi-org.brum.beds.ac.uk/10.3390/ph13080190
Received: 29 June 2020 / Revised: 28 July 2020 / Accepted: 30 July 2020 / Published: 11 August 2020
(This article belongs to the Special Issue Medicinal Plants 2020)
Obesity and hyper-intestinal permeability are interconnected. This study is designed to evaluate the ability of Mangifera indica seed kernel extract (MESK) in restoring the intestinal barrier and preventing obesity and associated metabolic complications in a high-fat diet-induced obese mouse model. Four groups of Swiss albino mice: (1) normal diet (ND), (2) high-fat diet (HFD), (3) HFD + Orlistat (100 µg/kg), and (4) HFD + MESK (75 µg/kg), were used to monitor various biochemical parameters associated with metabolic syndrome (glucose, total cholesterol, triglycerides) and body weight in an eight-week-long study. In vivo intestinal permeability was determined by the FITC-dextran method. Interestingly, MESK significantly reduced HFD-induced body weight gain, hepatic lipid accumulation, hepatic fibrosis, hyperglycemia, and dyslipidemia. Additionally, MESK treatment restored the expression of tight junction protein Zonula Occludens-1 (ZO-1) and Claudin-1 and hence prevented increased intestinal permeability induced by a high-fat diet. Moreover, it also increased the expression of potent satiety molecule Nesfatin-1 in the mouse jejunum. Our results, for the first time, establish MESK as a nutraceutical which prevents disruption of the intestinal barrier and thereby intercepts the adverse consequences of compromised intestinal permeability such as obesity, hyperglycemia, dyslipidemia, and systemic inflammation. View Full-Text
Keywords: metabolic syndrome; hepatic fibrosis; tight junction; gut barrier; nesfatin-1 metabolic syndrome; hepatic fibrosis; tight junction; gut barrier; nesfatin-1
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MDPI and ACS Style

Mujawdiya, P.K.; Sharma, P.; Sharad, S.; Kapur, S. Reversal of Increase in Intestinal Permeability by Mangifera indica Seed Kernel Extract in High-Fat Diet-Induced Obese Mice. Pharmaceuticals 2020, 13, 190. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13080190

AMA Style

Mujawdiya PK, Sharma P, Sharad S, Kapur S. Reversal of Increase in Intestinal Permeability by Mangifera indica Seed Kernel Extract in High-Fat Diet-Induced Obese Mice. Pharmaceuticals. 2020; 13(8):190. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13080190

Chicago/Turabian Style

Mujawdiya, Pavan K., Pravesh Sharma, Shashwat Sharad, and Suman Kapur. 2020. "Reversal of Increase in Intestinal Permeability by Mangifera indica Seed Kernel Extract in High-Fat Diet-Induced Obese Mice" Pharmaceuticals 13, no. 8: 190. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13080190

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