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Article

Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins

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Laboratory of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
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Laboratory of Pharmaceutical Analysis, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
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Department of Materials Science, University of Patras, Rio, 26504 Patras, Greece
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Foundation for Research and Technology Hellas, Institute of Chemical Engineering and High Temperature, Chemical Processes, 26504 Patras, Greece
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2020, 13(9), 203; https://0-doi-org.brum.beds.ac.uk/10.3390/ph13090203
Received: 28 June 2020 / Revised: 7 August 2020 / Accepted: 18 August 2020 / Published: 20 August 2020
(This article belongs to the Section Pharmaceutical Technology)
Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing. For the preparation of buccal films, solubility studies and rheological evaluations were conducted in distilled water and propylene-glycol (PG) as main solvent and viscosity/surface tension modifier, respectively. The increased solubility in the solvents’ mixture indicated that manufacturing of several doses of the THCl and NA is achievable. Various doses were deposited onto sugar-sheet substrates, by increasing the number of printing passes. The physiochemical characterization (SEM, DSC, FTIR) revealed that inkjet printing does not affect the solid state of the matrix. Water uptake studies were conducted, to compare the different vitamin-loaded formulations. The in vitro release studies indicated the burst release of both vitamins within 10 min, a preferable feature for buccal administration. The in vitro permeation studies indicated that higher concentrations of the vitamins onto the sugar sheet improved the in vitro permeation performance of printed formulations. View Full-Text
Keywords: buccal delivery; inkjet printing; B-complex vitamins; thiamine hydrochloride; nicotinic acid; release buccal delivery; inkjet printing; B-complex vitamins; thiamine hydrochloride; nicotinic acid; release
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MDPI and ACS Style

Eleftheriadis, G.; Monou, P.K.; Andriotis, E.; Mitsouli, E.; Moutafidou, N.; Markopoulou, C.; Bouropoulos, N.; Fatouros, D. Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins. Pharmaceuticals 2020, 13, 203. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13090203

AMA Style

Eleftheriadis G, Monou PK, Andriotis E, Mitsouli E, Moutafidou N, Markopoulou C, Bouropoulos N, Fatouros D. Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins. Pharmaceuticals. 2020; 13(9):203. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13090203

Chicago/Turabian Style

Eleftheriadis, Georgios, Paraskevi K. Monou, Eleftherios Andriotis, Elisavet Mitsouli, Nikoleta Moutafidou, Catherine Markopoulou, Nikolaos Bouropoulos, and Dimitrios Fatouros. 2020. "Development and Characterization of Inkjet Printed Edible Films for Buccal Delivery of B-Complex Vitamins" Pharmaceuticals 13, no. 9: 203. https://0-doi-org.brum.beds.ac.uk/10.3390/ph13090203

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