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Review

Antifibrotic and Anti-Inflammatory Actions of α-Melanocytic Hormone: New Roles for an Old Player

1
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21218, USA
2
Division of Pulmonary and Critical Care, University of Miami, Miami, FL 33146, USA
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2021, 14(1), 45; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14010045
Received: 25 December 2020 / Revised: 4 January 2021 / Accepted: 6 January 2021 / Published: 8 January 2021
(This article belongs to the Special Issue Lung Injury and Repair)
The melanocortin system encompasses melanocortin peptides, five receptors, and two endogenous antagonists. Besides pigmentary effects generated by α-Melanocytic Hormone (α-MSH), new physiologic roles in sexual activity, exocrine secretion, energy homeostasis, as well as immunomodulatory actions, exerted by melanocortins, have been described recently. Among the most common and burdensome consequences of chronic inflammation is the development of fibrosis. Depending on the regenerative capacity of the affected tissue and the quality of the inflammatory response, the outcome is not always perfect, with the development of some fibrosis. Despite the heterogeneous etiology and clinical presentations, fibrosis in many pathological states follows the same path of activation or migration of fibroblasts, and the differentiation of fibroblasts to myofibroblasts, which produce collagen and α-SMA in fibrosing tissue. The melanocortin agonists might have favorable effects on the trajectories leading from tissue injury to inflammation, from inflammation to fibrosis, and from fibrosis to organ dysfunction. In this review we briefly summarized the data on structure, receptor signaling, and anti-inflammatory and anti-fibrotic properties of α-MSH and proposed that α-MSH analogues might be promising future therapeutic candidates for inflammatory and fibrotic diseases, regarding their favorable safety profile. View Full-Text
Keywords: α-MSH; melanocortins; α-MSH analogues; anti-inflammatory; anti-fibrotic; MC1R; lung fibrosis α-MSH; melanocortins; α-MSH analogues; anti-inflammatory; anti-fibrotic; MC1R; lung fibrosis
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MDPI and ACS Style

Dinparastisaleh, R.; Mirsaeidi, M. Antifibrotic and Anti-Inflammatory Actions of α-Melanocytic Hormone: New Roles for an Old Player. Pharmaceuticals 2021, 14, 45. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14010045

AMA Style

Dinparastisaleh R, Mirsaeidi M. Antifibrotic and Anti-Inflammatory Actions of α-Melanocytic Hormone: New Roles for an Old Player. Pharmaceuticals. 2021; 14(1):45. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14010045

Chicago/Turabian Style

Dinparastisaleh, Roshan, and Mehdi Mirsaeidi. 2021. "Antifibrotic and Anti-Inflammatory Actions of α-Melanocytic Hormone: New Roles for an Old Player" Pharmaceuticals 14, no. 1: 45. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14010045

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