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Review

Endogenous Retroviruses in Nervous System Disorders

1
Department of Drug Design and Target Validation, Fraunhofer Institute for Cell Therapy and Immunology, 06120 Halle (Saale), Germany
2
Department of Neurology, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany
3
Department of Surgical and Conservative Pediatrics and Adolescent Medicine, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2021, 14(1), 70; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14010070
Received: 21 December 2020 / Revised: 11 January 2021 / Accepted: 13 January 2021 / Published: 16 January 2021
(This article belongs to the Special Issue New Drugs and Biologics For Treatment of Central Nervous Dysfunction)
Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies. View Full-Text
Keywords: human endogenous retrovirus; multiple sclerosis; amyotrophic lateral sclerosis; monoclonal antibodies human endogenous retrovirus; multiple sclerosis; amyotrophic lateral sclerosis; monoclonal antibodies
MDPI and ACS Style

Gröger, V.; Emmer, A.; Staege, M.S.; Cynis, H. Endogenous Retroviruses in Nervous System Disorders. Pharmaceuticals 2021, 14, 70. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14010070

AMA Style

Gröger V, Emmer A, Staege MS, Cynis H. Endogenous Retroviruses in Nervous System Disorders. Pharmaceuticals. 2021; 14(1):70. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14010070

Chicago/Turabian Style

Gröger, Victoria, Alexander Emmer, Martin S. Staege, and Holger Cynis. 2021. "Endogenous Retroviruses in Nervous System Disorders" Pharmaceuticals 14, no. 1: 70. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14010070

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