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Article

Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats

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Apitherapy Medical Center, Balaneşti, 217036 Gorj, Romania
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Nutrition and Dietetics Specialization, Faculty of Pharmacy, Vasile Goldis Western University of Arad, 310025 Arad, Romania
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Department of Pharmaceutical Botany, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania
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Petru Poni Institute of Macromolecular Chemistry, 700487 Iasi, Romania
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Department of Natural and Synthetic Polymers, Cristofor Simionescu Faculty of Chemical Engineering and Environmental Protection, Gheorghe Asachi Technical University of Iasi, 700050 Iasi, Romania
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Department of Pathology, Sf. Spiridon Emergency County Hospital, 700111 Iaşi, Romania
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Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
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Faculty of Psychology and Education Sciences, Alexandru Ioan Cuza University, 700554 Iasi, Romania
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Department of Pharmaceutical Technology, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania
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Academy of Romanian Scientists, 050094 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Academic Editors: Takehisa Hanawa, Yayoi Kawano, Viorica Patrulea, Mitsutoshi Sato and Olivier Jordan
Pharmaceuticals 2021, 14(11), 1146; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14111146
Received: 1 October 2021 / Revised: 3 November 2021 / Accepted: 8 November 2021 / Published: 11 November 2021
(This article belongs to the Special Issue Formulations for Wound Healing)
The wound-healing capacity of ointments based on bee products was investigated in vivo on three experimental models of incision, excision and heat burn. For this purpose, four ointments were prepared with propolis, honey, apilarnil (drone brood homogenate) and a mixture of these three apitherapy products. The ointments were applied topically for 21 days. Clinical and macroscopic evaluation was performed throughout the experiment, with the recording of the re-epithelialization period and determination of the wound contraction rate on days 6 and 9. The histopathological examination was performed on days 1, 3, 12 and 21 of the treatment. The topical formulations were also characterized from a rheological point of view in order to verify their stability. HPLC analysis of propolis revealed the presence of phenolic compounds, particularly ferulic acid and p-coumaric which were found in high amounts. All ointments had beneficial effects on wound contraction and the re-epithelialization period, but the most significant result, both macroscopically and especially in terms of histological architecture, was presented by the ointment that contains all three apitherapy products, due to their synergistic effect. View Full-Text
Keywords: bee products; honey; propolis; apilarnil; wound healing; rheological characterization bee products; honey; propolis; apilarnil; wound healing; rheological characterization
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MDPI and ACS Style

Andritoiu, C.V.; Lungu, C.; Danu, M.; Ivanescu, B.; Andriescu, C.E.; Vlase, L.; Havarneanu, C.; Iurciuc, C.E.; Popa, M. Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats. Pharmaceuticals 2021, 14, 1146. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14111146

AMA Style

Andritoiu CV, Lungu C, Danu M, Ivanescu B, Andriescu CE, Vlase L, Havarneanu C, Iurciuc CE, Popa M. Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats. Pharmaceuticals. 2021; 14(11):1146. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14111146

Chicago/Turabian Style

Andritoiu, Calin V., Cristina Lungu, Maricel Danu, Bianca Ivanescu, Corina E. Andriescu, Laurian Vlase, Corneliu Havarneanu, Camelia Elena Iurciuc, and Marcel Popa. 2021. "Evaluation of the Healing Effect of Ointments Based on Bee Products on Cutaneous Lesions in Wistar Rats" Pharmaceuticals 14, no. 11: 1146. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14111146

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