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Article

The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives

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Preclinical Safety/Translational Medicine, Novartis, 4057 Basel, Switzerland
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Pharmaceuticals, Investigational Toxicology, Bayer AG, 13342 Berlin, Germany
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Synapse Research Managers SL, 28006 Madrid, Spain
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ELIXIR, Hinxton, Cambridgeshire CB10 1SD, UK
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Chemical & Preclinical Safety, Merck Healthcare KGaA, 64293 Darmstadt, Germany
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Lhasa Limited, Leeds LS11 5PS, UK
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Leiden Academic Centre for Drug Research (LACDR), Leiden University, 2300 RA Leiden, The Netherlands
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Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain
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GRIB, Hospital del Mar Institute of Medical Research (IMIM), DCEXS, Pompeu Fabra University (UPF), 08003 Barcelona, Spain
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PDS Consultants, Leicester LE1 5XY, UK
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MedBioinformatics Solutions SL, 08018 Barcelona, Spain
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Department of Medical Informatics, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands
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Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Osvaldo Andrade Santos-Filho
Pharmaceuticals 2021, 14(3), 237; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14030237
Received: 27 January 2021 / Revised: 25 February 2021 / Accepted: 27 February 2021 / Published: 8 March 2021
(This article belongs to the Special Issue Computational Drug Discovery and Development in the Era of Big Data)
eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events. View Full-Text
Keywords: toxicology; drug safety; translational safety assessment; data sharing; integrative knowledge management; data mining; read across; predictive modelling toxicology; drug safety; translational safety assessment; data sharing; integrative knowledge management; data mining; read across; predictive modelling
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MDPI and ACS Style

Pognan, F.; Steger-Hartmann, T.; Díaz, C.; Blomberg, N.; Bringezu, F.; Briggs, K.; Callegaro, G.; Capella-Gutierrez, S.; Centeno, E.; Corvi, J.; Drew, P.; Drewe, W.C.; Fernández, J.M.; Furlong, L.I.; Guney, E.; Kors, J.A.; Mayer, M.A.; Pastor, M.; Piñero, J.; Ramírez-Anguita, J.M.; Ronzano, F.; Rowell, P.; Saüch-Pitarch, J.; Valencia, A.; van de Water, B.; van der Lei, J.; van Mulligen, E.; Sanz, F. The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives. Pharmaceuticals 2021, 14, 237. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14030237

AMA Style

Pognan F, Steger-Hartmann T, Díaz C, Blomberg N, Bringezu F, Briggs K, Callegaro G, Capella-Gutierrez S, Centeno E, Corvi J, Drew P, Drewe WC, Fernández JM, Furlong LI, Guney E, Kors JA, Mayer MA, Pastor M, Piñero J, Ramírez-Anguita JM, Ronzano F, Rowell P, Saüch-Pitarch J, Valencia A, van de Water B, van der Lei J, van Mulligen E, Sanz F. The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives. Pharmaceuticals. 2021; 14(3):237. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14030237

Chicago/Turabian Style

Pognan, François, Thomas Steger-Hartmann, Carlos Díaz, Niklas Blomberg, Frank Bringezu, Katharine Briggs, Giulia Callegaro, Salvador Capella-Gutierrez, Emilio Centeno, Javier Corvi, Philip Drew, William C. Drewe, José M. Fernández, Laura I. Furlong, Emre Guney, Jan A. Kors, Miguel A. Mayer, Manuel Pastor, Janet Piñero, Juan M. Ramírez-Anguita, Francesco Ronzano, Philip Rowell, Josep Saüch-Pitarch, Alfonso Valencia, Bob van de Water, Johan van der Lei, Erik van Mulligen, and Ferran Sanz. 2021. "The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives" Pharmaceuticals 14, no. 3: 237. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14030237

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