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Article

Covalently Functionalized Carbon Nano-Onions Integrated Gelatin Methacryloyl Nanocomposite Hydrogel Containing γ-Cyclodextrin as Drug Carrier for High-Performance pH-Triggered Drug Release

1
Department of Chemistry and Nanotechnology, School of Engineering and Science, Tecnologico de Monterrey, Monterrey, Nuevo Leon-64849, Mexico
2
Department of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Laura Catenacci, Milena Sorrenti and Maria Cristina Bonferoni
Pharmaceuticals 2021, 14(4), 291; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14040291
Received: 15 February 2021 / Revised: 16 March 2021 / Accepted: 23 March 2021 / Published: 25 March 2021
(This article belongs to the Special Issue New Frontiers in Cyclodextrin Technologies)
Herein, poly (n-(4-aminophenyl) methacrylamide)) carbon nano-onions (PAPMA-CNOs = f-CNOs) and γ-cyclodextrin/DOX-complex (CD) reinforced gelatin methacryloyl (GelMA)/f-CNOs/CD supramolecular hydrogel interfaces were fabricated using the photo-crosslinking technique. The physicochemical properties, morphology, biodegradation, and swelling properties of hydrogels were investigated. The composite hydrogels demonstrated enriched drug release under the acidic conditions (pH 4.5 = 99%, and pH 6.0 = 82%) over 18 days. Owing to the f-CNOs inclusion, GelMA/f-CNOs/CD supramolecular hydrogels presented augmented tensile strength (σult = 356.1 ± 3.4 MPa), toughness (K = 51.5 ± 0.24 Jg−1), and Young’s modulus (E = 41.8 ± 1.4 GPa). The strengthening of GelMA/f-CNOs/CD hydrogel systems indicates its good dispersion and the degree of polymer enveloping of f-CNOs within GelMA matrixes. Furthermore, the obtained hydrogels showed improved cell viability with human fibroblast cells. Nevertheless, the primed supramolecular hydrogels would pave the way for the controlled delivery systems for future drug delivery. View Full-Text
Keywords: GelMA/f-CNOs/CD supramolecular hydrogels; stimuli-responsive drug release; mechanical properties; cell viability GelMA/f-CNOs/CD supramolecular hydrogels; stimuli-responsive drug release; mechanical properties; cell viability
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MDPI and ACS Style

Mamidi, N.; Velasco Delgadillo, R.M.; Barrera, E.V. Covalently Functionalized Carbon Nano-Onions Integrated Gelatin Methacryloyl Nanocomposite Hydrogel Containing γ-Cyclodextrin as Drug Carrier for High-Performance pH-Triggered Drug Release. Pharmaceuticals 2021, 14, 291. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14040291

AMA Style

Mamidi N, Velasco Delgadillo RM, Barrera EV. Covalently Functionalized Carbon Nano-Onions Integrated Gelatin Methacryloyl Nanocomposite Hydrogel Containing γ-Cyclodextrin as Drug Carrier for High-Performance pH-Triggered Drug Release. Pharmaceuticals. 2021; 14(4):291. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14040291

Chicago/Turabian Style

Mamidi, Narsimha, Ramiro M. Velasco Delgadillo, and Enrique V. Barrera 2021. "Covalently Functionalized Carbon Nano-Onions Integrated Gelatin Methacryloyl Nanocomposite Hydrogel Containing γ-Cyclodextrin as Drug Carrier for High-Performance pH-Triggered Drug Release" Pharmaceuticals 14, no. 4: 291. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14040291

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