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Article

Polyvinyl Alcohol-Based 3D Printed Tablets: Novel Insight into the Influence of Polymer Particle Size on Filament Preparation and Drug Release Performance

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Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 41 Victor Babeș Street, 400012 Cluj-Napoca, Romania
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Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Interdisciplinary Excellence Centre, 6 Eötvös Street, H-6720 Szeged, Hungary
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Department of Pharmaceutical Analysis, Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 6 Louis Pasteur Street, 400349 Cluj-Napoca, Romania
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National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath Street, 400293 Cluj-Napoca, Romania
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Author to whom correspondence should be addressed.
Academic Editors: Alicia López-Castellano and Vicent Rodilla
Pharmaceuticals 2021, 14(5), 418; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14050418
Received: 31 March 2021 / Revised: 23 April 2021 / Accepted: 26 April 2021 / Published: 1 May 2021
Three-dimensional printing (3DP) by fused deposition modeling (FDM) has gained momentum as a promising pharmaceutical manufacturing method due to encouraging forward-looking perspectives in personalized medicine preparation. The current challenges the technology has for applicability in the fabrication of solid dosage forms include the limited range of suitable pharmaceutical grade thermoplastic materials. Hence, it is important to investigate the implications of variable properties of the polymeric carrier on the preparation steps and the final output, as versatile products could be obtained by using the same material. In this study, we highlighted the influence of polyvinyl alcohol (PVA) particle size on the residence time of the mixtures in the extruder during the drug-loaded filament preparation step and the consequent impact on drug release from the 3D printed dosage form. We enhanced filament printability by exploiting the plasticizing potential of the active pharmaceutical ingredient (API) and we explored a channeled tablet model as a design strategy for dissolution facilitating purposes. Our findings disclosed a new perspective regarding material considerations for the preparation of PVA-based solid dosage forms by coupling hot melt extrusion (HME) and FDM-3DP. View Full-Text
Keywords: 3D printing; fused deposition modeling; hot melt extrusion; polyvinyl alcohol; residence time 3D printing; fused deposition modeling; hot melt extrusion; polyvinyl alcohol; residence time
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MDPI and ACS Style

Crișan, A.G.; Porfire, A.; Ambrus, R.; Katona, G.; Rus, L.M.; Porav, A.S.; Ilyés, K.; Tomuță, I. Polyvinyl Alcohol-Based 3D Printed Tablets: Novel Insight into the Influence of Polymer Particle Size on Filament Preparation and Drug Release Performance. Pharmaceuticals 2021, 14, 418. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14050418

AMA Style

Crișan AG, Porfire A, Ambrus R, Katona G, Rus LM, Porav AS, Ilyés K, Tomuță I. Polyvinyl Alcohol-Based 3D Printed Tablets: Novel Insight into the Influence of Polymer Particle Size on Filament Preparation and Drug Release Performance. Pharmaceuticals. 2021; 14(5):418. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14050418

Chicago/Turabian Style

Crișan, Andrea G., Alina Porfire, Rita Ambrus, Gábor Katona, Lucia M. Rus, Alin S. Porav, Kinga Ilyés, and Ioan Tomuță. 2021. "Polyvinyl Alcohol-Based 3D Printed Tablets: Novel Insight into the Influence of Polymer Particle Size on Filament Preparation and Drug Release Performance" Pharmaceuticals 14, no. 5: 418. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14050418

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