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Review

Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents

1
LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
2
Department of Organic and Inorganic Chemistry, University of Oviedo, Julián Clavería 7, 33006 Oviedo, Spain
*
Authors to whom correspondence should be addressed.
Academic Editors: Jean Jacques Vanden Eynde and Annie Mayence
Pharmaceuticals 2021, 14(6), 546; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060546
Received: 20 April 2021 / Revised: 3 June 2021 / Accepted: 3 June 2021 / Published: 7 June 2021
(This article belongs to the Special Issue COVID-19 in Pharmaceuticals)
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread all over the world, creating a devastating socio-economic impact. Even though protective vaccines are starting to be administered, an effective antiviral agent for the prevention and treatment of COVID-19 is not available yet. Moreover, since new and deadly CoVs can emerge at any time with the potential of becoming pandemics, the development of therapeutic agents against potentially deadly CoVs is a research area of much current interest. In the search for anti-coronaviral drugs, researchers soon turned their heads towards glycosylated flavonoids. Glycosyl flavonoids, widespread in the plant kingdom, have received a lot of attention due to their widely recognized antioxidant, anti-inflammatory, neuroprotective, anticarcinogenic, antidiabetic, antimicrobial, and antiviral properties together with their capacity to modulate key cellular functions. The wide range of biological activities displayed by glycosyl flavonoids, along with their low toxicity, make them ideal candidates for drug development. In this review, we examine and discuss the up-to-date developments on glycosyl flavonoids as evidence-based natural sources of antivirals against coronaviruses and their potential role in the management of COVID-19. View Full-Text
Keywords: coronavirus disease; SARS-CoV-2; flavonoids; glycosyl flavonoids; antivirals; spike glycoprotein; protease 3CLpro coronavirus disease; SARS-CoV-2; flavonoids; glycosyl flavonoids; antivirals; spike glycoprotein; protease 3CLpro
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MDPI and ACS Style

Godinho, P.I.C.; Soengas, R.G.; Silva, V.L.M. Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents. Pharmaceuticals 2021, 14, 546. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060546

AMA Style

Godinho PIC, Soengas RG, Silva VLM. Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents. Pharmaceuticals. 2021; 14(6):546. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060546

Chicago/Turabian Style

Godinho, Patrícia I.C., Raquel G. Soengas, and Vera L.M. Silva 2021. "Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents" Pharmaceuticals 14, no. 6: 546. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060546

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