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Review

Safety and Benefits of Contraceptives Implants: A Systematic Review

1
Operative Unit of Obstetric and Gynaecology, Pugliese-Ciaccio Hospital, 88100 Catanzaro, Italy
2
Department of Obstetrics and Gynaecology, “Magna Graecia” University, 88100 Catanzaro, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Giovanni Grandi and Maria Chiara del Savio
Pharmaceuticals 2021, 14(6), 548; https://doi.org/10.3390/ph14060548
Received: 7 May 2021 / Revised: 2 June 2021 / Accepted: 3 June 2021 / Published: 8 June 2021
(This article belongs to the Special Issue Safety and Benefits of Modern Hormonal Contraceptives)
Progestin-only contraceptive implants provide long-acting, highly effective reversible contraception. We searched the medical publications in PubMed, CENTRAL, and EMBASE for relevant articles on hormonal implants published in English between 1990 and 2021. Levonorgestrel (LNG) 6-capsule subdermal implants represented the first effective system approved for reversible contraception. The etonogestrel (ENG) single rod dispositive has been widely employed in clinical practice, since it is a highly effective and safe contraceptive method. Abnormal menstrual bleeding is a common ENG side effect, representing the main reason for its premature discontinuation. Emerging evidence demonstrated that it is possible to extend the use of the ENG implant beyond the three-year period for which it is approved. The ENG implant could be an effective and discrete alternative to the IUD in young girls, such as post-partum/post-abortion. Implants should be inserted by trained skilled clinicians who previously provide adequate counselling about their contraceptive effect, benefits, and any possible adverse events. More studies are needed to validate the extended use of the ENG implant for up to 5 years. View Full-Text
Keywords: contraception; etonogestrel; implanon; LARC; levonorgestrel; nexplanon; subdermal implant contraception; etonogestrel; implanon; LARC; levonorgestrel; nexplanon; subdermal implant
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MDPI and ACS Style

Rocca, M.L.; Palumbo, A.R.; Visconti, F.; Di Carlo, C. Safety and Benefits of Contraceptives Implants: A Systematic Review. Pharmaceuticals 2021, 14, 548. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060548

AMA Style

Rocca ML, Palumbo AR, Visconti F, Di Carlo C. Safety and Benefits of Contraceptives Implants: A Systematic Review. Pharmaceuticals. 2021; 14(6):548. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060548

Chicago/Turabian Style

Rocca, Morena L., Anna R. Palumbo, Federica Visconti, and Costantino Di Carlo. 2021. "Safety and Benefits of Contraceptives Implants: A Systematic Review" Pharmaceuticals 14, no. 6: 548. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060548

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