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Article

Antimicrobial Peptides: Identification of two Beta-Defensins in a Teleost Fish, the European Sea Bass (Dicentrarchus labrax)

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i3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal
2
Iron and Innate Immunity, IBMC—Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal
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Programa Doutoral em Biologia Molecular e Celular (MCbiology), ICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313, Porto, Portugal
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ICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal
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CIIMAR—Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto, 4450-208 Porto, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Angela Arciello
Pharmaceuticals 2021, 14(6), 566; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060566
Received: 24 May 2021 / Revised: 8 June 2021 / Accepted: 9 June 2021 / Published: 14 June 2021
Beta-defensins consist in a group of cysteine-rich antimicrobial peptides (AMPs), widely found throughout vertebrate species, including teleost fish, with antimicrobial and immunomodulatory activities. However, although the European sea bass (Dicentrarchus labrax) is one of the most commercially important farmed fish species in the Mediterranean area, the characterization of its beta-defensins and its potential applications are still missing. In this study, we characterized two members of the beta-defensin family in this species. Phylogenetic and synteny analysis places sea bass peptides in the beta-defensin subfamilies 1 and 2, sharing similar features with the other members, including the six cysteines and the tertiary structure, that consists in three antiparallel beta-sheets, with beta-defensin 1 presenting an extra alpha-helix at the N-terminal. Further studies are necessary to uncover the functions of sea bass beta-defensins, particularly their antimicrobial and immunomodulatory properties, in order to develop novel prophylactic or therapeutic compounds to be used in aquaculture production. View Full-Text
Keywords: aquaculture; European sea bass (Dicentrarchus labrax); antimicrobial peptides; beta-defensins aquaculture; European sea bass (Dicentrarchus labrax); antimicrobial peptides; beta-defensins
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MDPI and ACS Style

Barroso, C.; Carvalho, P.; Gonçalves, J.F.M.; Rodrigues, P.N.S.; Neves, J.V. Antimicrobial Peptides: Identification of two Beta-Defensins in a Teleost Fish, the European Sea Bass (Dicentrarchus labrax). Pharmaceuticals 2021, 14, 566. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060566

AMA Style

Barroso C, Carvalho P, Gonçalves JFM, Rodrigues PNS, Neves JV. Antimicrobial Peptides: Identification of two Beta-Defensins in a Teleost Fish, the European Sea Bass (Dicentrarchus labrax). Pharmaceuticals. 2021; 14(6):566. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060566

Chicago/Turabian Style

Barroso, Carolina, Pedro Carvalho, José F.M. Gonçalves, Pedro N.S. Rodrigues, and João V. Neves 2021. "Antimicrobial Peptides: Identification of two Beta-Defensins in a Teleost Fish, the European Sea Bass (Dicentrarchus labrax)" Pharmaceuticals 14, no. 6: 566. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060566

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