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Pharmaceuticals
Volume 14
Issue 6
10.3390/ph14060585
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Article
Peer-Review Record

HDAC Inhibitor Abrogates LTA−Induced PAI-1 Expression in Pleural Mesothelial Cells and Attenuates Experimental Pleural Fibrosis

Pharmaceuticals 2021, 14(6), 585; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060585
by Wei-Lin Chen 1,†, Mei-Chuan Chen 2,†, Shang-Fu Hsu 2, Shih-Hsin Hsiao 2,3,* and Chi-Li Chung 2,3,4,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Pharmaceuticals 2021, 14(6), 585; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14060585
Submission received: 1 June 2021 / Revised: 15 June 2021 / Accepted: 16 June 2021 / Published: 18 June 2021
(This article belongs to the Special Issue Lung Injury and Repair)

Round 1

Reviewer 1 Report

Authors performed the requested experiments showing a partial involvement of JNK activation in their system. Authors should still change figure legends describing data obtained from Western Blot by Optical densitometry analysis. Data shown in the figures are fold change and not only means of different experiments.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Thank you for the new version of the manuscript; all my comments were taken into account by the authors. I have some minor points and remarks.

 

-Page 4, line 35, I think it should be better to slightly modify the sentence to add the information on what kind of predictive value is PAI-1. The PAI-1 level presents an excellent predictive value on RPT>10mm if I understand the paper well.

- Page 4 lin 36 “Correlate well with….” Maybe splitting this long and complex sentence would help the reader accurately understand the sentence's information.

-Page 5, line 46 “were stimulated with LTA” better suited.

- Page 5. The maximal effect is recorded with 1mg/ml of LTA. Do authors have some explanation or hypothesis on why dose-response is not observed?

-Page 5, line 47, I think that the sentence must be rewritten in that way: LTA stimulates the production of PAI-1” No data on the expression level of PAI-1 mRNA are given.

- Line 51, “Abrogate the stimulatory effect of LTA on PAI-1 production”.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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