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Article

Antiparasitic Properties of Cardiovascular Agents against Human Intravascular Parasite Schistosoma mansoni

1
Research Center for Neglected Diseases, Guarulhos University, Praça Tereza Cristina 229, São Paulo 07023-070, SP, Brazil
2
Institute of Physics, University of São Paulo, São Paulo 05508-060, SP, Brazil
3
Department of Biophysics and Physiology, Federal University of Piaui, Teresina 64049-550, PI, Brazil
4
Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717853577, Iran
5
CICECO-Aveiro Institute of Materials & Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal
6
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
*
Authors to whom correspondence should be addressed.
Academic Editor: Marcelo J. Nieto
Pharmaceuticals 2021, 14(7), 686; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14070686
Received: 18 June 2021 / Revised: 12 July 2021 / Accepted: 13 July 2021 / Published: 16 July 2021
(This article belongs to the Special Issue Antiparasitics)
The intravascular parasitic worm Schistosoma mansoni is a causative agent of schistosomiasis, a disease of great global public health significance. Praziquantel is the only drug available to treat schistosomiasis and there is an urgent demand for new anthelmintic agents. Adopting a phenotypic drug screening strategy, here, we evaluated the antiparasitic properties of 46 commercially available cardiovascular drugs against S. mansoni. From these screenings, we found that amiodarone, telmisartan, propafenone, methyldopa, and doxazosin affected the viability of schistosomes in vitro, with effective concentrations of 50% (EC50) and 90% (EC90) values ranging from 8 to 50 µM. These results were further supported by scanning electron microscopy analysis. Subsequently, the most effective drug (amiodarone) was further tested in a murine model of schistosomiasis for both early and chronic S. mansoni infections using a single oral dose of 400 mg/kg or 100 mg/kg daily for five consecutive days. Amiodarone had a low efficacy in chronic infection, with the worm and egg burden reduction ranging from 10 to 30%. In contrast, amiodarone caused a significant reduction in worm and egg burden in early infection (>50%). Comparatively, treatment with amiodarone is more effective in early infection than praziquantel, demonstrating the potential role of this cardiovascular drug as an antischistosomal agent. View Full-Text
Keywords: antiparasitic; anthelmintic; antischistosomal; drug repurposing; amiodarone; cardiovascular agents; antiarrhythmic; schistosomiasis antiparasitic; anthelmintic; antischistosomal; drug repurposing; amiodarone; cardiovascular agents; antiarrhythmic; schistosomiasis
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MDPI and ACS Style

Porto, R.; Mengarda, A.C.; Cajas, R.A.; Salvadori, M.C.; Teixeira, F.S.; Arcanjo, D.D.R.; Siyadatpanah, A.; Pereira, M.d.L.; Wilairatana, P.; Moraes, J.d. Antiparasitic Properties of Cardiovascular Agents against Human Intravascular Parasite Schistosoma mansoni. Pharmaceuticals 2021, 14, 686. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14070686

AMA Style

Porto R, Mengarda AC, Cajas RA, Salvadori MC, Teixeira FS, Arcanjo DDR, Siyadatpanah A, Pereira MdL, Wilairatana P, Moraes Jd. Antiparasitic Properties of Cardiovascular Agents against Human Intravascular Parasite Schistosoma mansoni. Pharmaceuticals. 2021; 14(7):686. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14070686

Chicago/Turabian Style

Porto, Raquel, Ana C. Mengarda, Rayssa A. Cajas, Maria C. Salvadori, Fernanda S. Teixeira, Daniel D.R. Arcanjo, Abolghasem Siyadatpanah, Maria d.L. Pereira, Polrat Wilairatana, and Josué d. Moraes 2021. "Antiparasitic Properties of Cardiovascular Agents against Human Intravascular Parasite Schistosoma mansoni" Pharmaceuticals 14, no. 7: 686. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14070686

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