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Article

Albumin Nanoparticle Formulation for Heart-Targeted Drug Delivery: In Vivo Assessment of Congestive Heart Failure

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Department of Biomedical Engineering, Biomedical Technology and Cell Therapy Research Laboratory, McGill University, 3775 University Street, Montreal, QC H3A 2B4, Canada
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Division of Experimental Medicine, McGill University, 1001 Boulevard Décarie, Montréal, QC H4A 3J1, Canada
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Division of Cardiac Surgery and Surgical Research, McGill University, 1001 Boulevard Décarie, Montréal, QC H4A 3J1, Canada
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Meakins Christie Laboratories, Department of Microbiology and Immunology, McGill University, 1001 Boulevard Décarie, Montréal, QC H4A 3J1, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Kazuaki Taguchi and Victor Tuan Giam Chuang
Pharmaceuticals 2021, 14(7), 697; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14070697
Received: 10 June 2021 / Revised: 5 July 2021 / Accepted: 9 July 2021 / Published: 19 July 2021
Congestive heart failure is a fatal cardiovascular disease resulting in tissue necrosis and loss of cardiac contractile function. Inotropic drugs such as milrinone are commonly used to improve the myocardial contractility and heart function. However, milrinone is associated with severe side effects and lower circulation time. In this article, a novel protein nanoparticle formulation for heart-targeted delivery of milrinone has been designed and tested. The formulation was prepared using albumin protein conjugated with the targeting ligand, angiotensin II peptide to form nanoparticles following the ethanol desolvation method. The formulation was characterized for size, charge, and morphology and tested in a rat model of congestive heart failure to study pharmacokinetics, biodistribution, and efficacy. The overall cardiac output parameters were evaluated comparing the formulation with the control non-targeted drug, milrinone lactate. This formulation exhibited improved pharmacokinetics with a mean retention time of 123.7 min, half-life of 101.3 min, and clearance rate of 0.24 L/(kg*h). The targeted formulation also significantly improved ejection fraction and fractional shortening parameters thus improving cardiac function. This study demonstrates a new approach in delivering inotropic drugs such as milrinone for superior treatment of congestive heart failure. View Full-Text
Keywords: albumin; nanoparticle; protein; milrinone; heart failure; drug delivery; pharmacokinetics; biodistribution albumin; nanoparticle; protein; milrinone; heart failure; drug delivery; pharmacokinetics; biodistribution
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MDPI and ACS Style

Lomis, N.; Sarfaraz, Z.K.; Alruwaih, A.; Westfall, S.; Shum-Tim, D.; Prakash, S. Albumin Nanoparticle Formulation for Heart-Targeted Drug Delivery: In Vivo Assessment of Congestive Heart Failure. Pharmaceuticals 2021, 14, 697. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14070697

AMA Style

Lomis N, Sarfaraz ZK, Alruwaih A, Westfall S, Shum-Tim D, Prakash S. Albumin Nanoparticle Formulation for Heart-Targeted Drug Delivery: In Vivo Assessment of Congestive Heart Failure. Pharmaceuticals. 2021; 14(7):697. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14070697

Chicago/Turabian Style

Lomis, Nikita, Ziyab K. Sarfaraz, Aiman Alruwaih, Susan Westfall, Dominique Shum-Tim, and Satya Prakash. 2021. "Albumin Nanoparticle Formulation for Heart-Targeted Drug Delivery: In Vivo Assessment of Congestive Heart Failure" Pharmaceuticals 14, no. 7: 697. https://0-doi-org.brum.beds.ac.uk/10.3390/ph14070697

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