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Article

Anti-Vasculogenic, Antioxidant, and Anti-Inflammatory Activities of Sulfated Polysaccharide Derived from Codium tomentosum: Pharmacokinetic Assay

1
Laboratory of Medicinal and Environment Chemistry, Higher Institute of Biotechnology, University of Sfax, Sfax 3000, Tunisia
2
Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences of Settat, Settat 26000, Morocco
3
Laboratory Agrifood and Health, Faculty of Science and Technology, Hasan First University of Settat, Settat 26000, Morocco
4
Laboratory of Anatomopathology, CHU Habib Bourguiba, University of Sfax, Sfax 3029, Tunisia
5
Laboratory of Hematology, CHU Habib Bourguiba, University of Sfax, Sfax 3029, Tunisia
6
Neurology Department, Cayenne General Hospital, Cayenne 97300, French Guiana
7
Clinical Investigation Center, CIC INSERM 142, Cayenne General Hospital Andrée Rosemon, Guiana University, Cayenne 97300, French Guiana
8
Emergency Department, Cayenne General Hospital, Cayenne 97300, French Guiana
9
Department of Biology, University of Ha’il, Ha’il 81451, Saudi Arabia
10
Section of Histology-Cytology, Medicine Faculty of Tunis, University of Tunis El Manar, La Rabta 1007, Tunisia
11
Biome and Immunopathology CNRS UMR-9017, Inserm U 1019, Université de Guyane, Cayenne 97300, French Guiana
12
Intensive Care Unit, Cayenne General Hospital, Cayenne 97300, French Guiana
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
Pharmaceuticals 2024, 17(6), 672; https://0-doi-org.brum.beds.ac.uk/10.3390/ph17060672
Submission received: 8 April 2024 / Revised: 3 May 2024 / Accepted: 8 May 2024 / Published: 23 May 2024
(This article belongs to the Topic Research in Pharmacological Therapies)

Abstract

The purpose of this paper was to investigate the anti-inflammatory and anti-angiogenic activities of sulfated polysaccharide from C. tomentosum (PCT) using carrageenan (CARR)-induced paw edema in a rat model and anti-vasculogenic activity on a chorioallantoic membrane assay (CAM) model. Based on in vitro tests of anti-radical, total antioxidant, and reducing power activities, PCT presents a real interest via its antioxidant activity and ability to scavenge radical species. The in vivo pharmacological tests suggest that PCT possesses anti-inflammatory action by reducing paw edema and leukocyte migration, maintaining the redox equilibrium, and stabilizing the cellular level of several pro-/antioxidant system markers. It could significantly decrease the malondialdehyde levels and increase superoxide dismutase, glutathione peroxidase, and glutathione activities in local paw edema and erythrocytes during the acute inflammatory reaction of CARR. PCT pretreatment was effective against DNA alterations in the blood lymphocytes of inflamed rats and reduced the hematological alteration by restoring blood parameters to normal levels. The anti-angiogenic activity results revealed that CAM neovascularization, defined as the formation of new vessel numbers and branching patterns, was decreased by PCT in a dose-dependent manner, which supported the in silico bioavailability and pharmacokinetic findings. These results indicated the therapeutic effects of polysaccharides from C. tomentosum and their possible use as anti-proliferative molecules based on their antioxidant, anti-inflammatory, and anti-angiogenic activities.
Keywords: polysaccharide; antioxidant activities; oxidative stress; inflammatory reaction; Codium tomentosum; pharmacokinetics; bioavailability; anti-angiogenic action polysaccharide; antioxidant activities; oxidative stress; inflammatory reaction; Codium tomentosum; pharmacokinetics; bioavailability; anti-angiogenic action

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MDPI and ACS Style

Lakhrem, M.; Eleroui, M.; Boujhoud, Z.; Feki, A.; Dghim, A.; Essayagh, S.; Hilali, S.; Bouhamed, M.; Kallel, C.; Deschamps, N.; et al. Anti-Vasculogenic, Antioxidant, and Anti-Inflammatory Activities of Sulfated Polysaccharide Derived from Codium tomentosum: Pharmacokinetic Assay. Pharmaceuticals 2024, 17, 672. https://0-doi-org.brum.beds.ac.uk/10.3390/ph17060672

AMA Style

Lakhrem M, Eleroui M, Boujhoud Z, Feki A, Dghim A, Essayagh S, Hilali S, Bouhamed M, Kallel C, Deschamps N, et al. Anti-Vasculogenic, Antioxidant, and Anti-Inflammatory Activities of Sulfated Polysaccharide Derived from Codium tomentosum: Pharmacokinetic Assay. Pharmaceuticals. 2024; 17(6):672. https://0-doi-org.brum.beds.ac.uk/10.3390/ph17060672

Chicago/Turabian Style

Lakhrem, Marwa, Malek Eleroui, Zakaria Boujhoud, Amal Feki, Amel Dghim, Sanah Essayagh, Said Hilali, Marwa Bouhamed, Choumous Kallel, Nathalie Deschamps, and et al. 2024. "Anti-Vasculogenic, Antioxidant, and Anti-Inflammatory Activities of Sulfated Polysaccharide Derived from Codium tomentosum: Pharmacokinetic Assay" Pharmaceuticals 17, no. 6: 672. https://0-doi-org.brum.beds.ac.uk/10.3390/ph17060672

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