Helicobacter pylori genotypes in Lithuanian patients with chronic gastritis and duodenal ulcer
Abstract
Results. The cagPAI was identified in 59.3% of Lithuanian H. pylori strains investigated. H. pylori strains cultured from duodenal ulcer (DU) patients more frequently (P<0.01) contained cagPAI and vacA s1 genotypes (75.7% and 75.7%, respectively) in comparison to isolates from chronic gastritis (CG) patients (45.5% and 40.9%, respectively). Evaluation of nucleotide sequence of the vacA middle-region revealed that vacA s2/m2 genotype was more frequent in CG than in DU patients (56.8% and 24.3%, respectively; P<0.05). We have not found any differences in the frequency of iceA1 genotype between the DU and CG patients (46.0% and 40.9%, respectively; P>0.05).
Conclusion. Our study suggests that cagPAI and vacA s1 genotypes are associated with peptic ulceration in Lithuanian patients infected by H. pylori.
Share and Cite
Miciulevičienė, J.; Čalkauskas, H.; Jonaitis, L.; Kiudelis, G.; Tamošiūnas, V.; Praškevičius, A.; Kupčinskas, L.; Berg, D. Helicobacter pylori genotypes in Lithuanian patients with chronic gastritis and duodenal ulcer. Medicina 2008, 44, 449. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina44060058
Miciulevičienė J, Čalkauskas H, Jonaitis L, Kiudelis G, Tamošiūnas V, Praškevičius A, Kupčinskas L, Berg D. Helicobacter pylori genotypes in Lithuanian patients with chronic gastritis and duodenal ulcer. Medicina. 2008; 44(6):449. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina44060058
Chicago/Turabian StyleMiciulevičienė, Jolanta, Henrikas Čalkauskas, Laimas Jonaitis, Gediminas Kiudelis, Vytas Tamošiūnas, Antanas Praškevičius, Limas Kupčinskas, and Duglas Berg. 2008. "Helicobacter pylori genotypes in Lithuanian patients with chronic gastritis and duodenal ulcer" Medicina 44, no. 6: 449. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina44060058