Next Article in Journal
Comparison of Carotid Ultrasound Indices and the Triglyceride Glucose Index in Hypertensive and Normotensive Community-Dwelling Individuals: A Case Control Study for Evaluating Atherosclerosis
Next Article in Special Issue
Serum Levels of Carbamylated LDL and Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated with Coronary Artery Disease in Patients with Metabolic Syndrome
Previous Article in Journal
Changes in Morphology and Presence of Pinopodes in Endometrial Cells during the Luteal Phase in Women with Infertility Problems: A Pilot Study

Cardiac Glucolipotoxicity and Cardiovascular Outcomes

Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa
Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Stellenbosch, Tygerberg 7505, South Africa
Received: 7 September 2018 / Revised: 4 October 2018 / Accepted: 5 October 2018 / Published: 11 October 2018
Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the heart and vasculature culminate in diabetic cardiomyopathy, coronary artery disease, ischemia and eventually heart failure. Glucolipotoxicity describes the combined, often synergistic, adverse effects of elevated glucose and free fatty acid concentrations on heart structure, function, and survival. The quality of fatty acid shapes the cardiac structure and function, often influencing survival. A healthy fatty acid balance is therefore critical for maintaining cardiac integrity and function. View Full-Text
Keywords: bioenergetics; cardiac development; diabetes; fatty acids; glucose transport; hyperglycemia bioenergetics; cardiac development; diabetes; fatty acids; glucose transport; hyperglycemia
Show Figures

Figure 1

MDPI and ACS Style

Cerf, M.E. Cardiac Glucolipotoxicity and Cardiovascular Outcomes. Medicina 2018, 54, 70.

AMA Style

Cerf ME. Cardiac Glucolipotoxicity and Cardiovascular Outcomes. Medicina. 2018; 54(5):70.

Chicago/Turabian Style

Cerf, Marlon E. 2018. "Cardiac Glucolipotoxicity and Cardiovascular Outcomes" Medicina 54, no. 5: 70.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop