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Cardiac Glucolipotoxicity and Cardiovascular Outcomes

1
Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa
2
Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Stellenbosch, Tygerberg 7505, South Africa
Received: 7 September 2018 / Revised: 4 October 2018 / Accepted: 5 October 2018 / Published: 11 October 2018
Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the heart and vasculature culminate in diabetic cardiomyopathy, coronary artery disease, ischemia and eventually heart failure. Glucolipotoxicity describes the combined, often synergistic, adverse effects of elevated glucose and free fatty acid concentrations on heart structure, function, and survival. The quality of fatty acid shapes the cardiac structure and function, often influencing survival. A healthy fatty acid balance is therefore critical for maintaining cardiac integrity and function. View Full-Text
Keywords: bioenergetics; cardiac development; diabetes; fatty acids; glucose transport; hyperglycemia bioenergetics; cardiac development; diabetes; fatty acids; glucose transport; hyperglycemia
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MDPI and ACS Style

Cerf, M.E. Cardiac Glucolipotoxicity and Cardiovascular Outcomes. Medicina 2018, 54, 70. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina54050070

AMA Style

Cerf ME. Cardiac Glucolipotoxicity and Cardiovascular Outcomes. Medicina. 2018; 54(5):70. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina54050070

Chicago/Turabian Style

Cerf, Marlon E. 2018. "Cardiac Glucolipotoxicity and Cardiovascular Outcomes" Medicina 54, no. 5: 70. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina54050070

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