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A Systematic Review of the Role of Prebiotics and Probiotics in Autism Spectrum Disorders

MOH Holdings Pte Ltd., 1 Maritime Square, Singapore 099253, Singapore
KK Women’s and Children’s Hospital, 100 Bukit Timah Rd, Singapore 229899, Singapore
National University Hospital, National University Health System, Singapore 119074, Singapore
Department of Child and Adolescent Psychiatry, Institute of Mental Health, 10 Buangkok View, Singapore 539747, Singapore
Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
Author to whom correspondence should be addressed.
Received: 21 February 2019 / Revised: 25 March 2019 / Accepted: 7 May 2019 / Published: 10 May 2019
(This article belongs to the Special Issue Complementary and Integrative Medicine)
Background: Autism spectrum disorder (ASD) is a complex developmental condition typically characterized by deficits in social and communicative behaviors as well as repetitive patterns of behaviors. Despite its prevalence (affecting 0.1% to 1.8% of the global population), the pathogenesis of ASD remains incompletely understood. Patients with ASD are reported to have more frequent gastrointestinal (GI) complaints. There is some anecdotal evidence that probiotics are able to alleviate GI symptoms as well as improve behavioral issues in children with ASD. However, systematic reviews of the effect of prebiotics/probiotics on ASD and its associated symptoms are lacking. Methods: Using the keywords (prebiotics OR probiotics OR microbiota OR gut) AND (autism OR social OR ASD), a systematic literature search was conducted on PubMed, EMBASE, Medline, and Google Scholar databases. The inclusion criteria were original clinical trials, published in English between the period 1st January 1988 and 1st February 2019. Results: A total of eight clinical trials were systematically reviewed. Two clinical trials examined the use of prebiotic and/or diet exclusion while six involved the use of probiotic supplementation in children with ASD. Most of these were prospective, open-label studies. Prebiotics only improved certain GI symptoms; however, when combined with an exclusion diet (gluten and casein free) showed a significant reduction in anti-sociability scores. As for probiotics, there is limited evidence to support the role of probiotics in alleviating the GI or behavioral symptoms in children with ASD. The two available double-blind, randomized, placebo-controlled trials found no significant difference in GI symptoms and behavior. Conclusion: Despite promising preclinical findings, prebiotics and probiotics have demonstrated an overall limited efficacy in the management of GI or behavioral symptoms in children with ASD. In addition, there was no standardized probiotics regimen, with multiple different strains and concentrations of probiotics, and variable duration of treatments. View Full-Text
Keywords: probiotics; Lactobacillus; Bifidobacterium; autism; ASD; gut microbiota probiotics; Lactobacillus; Bifidobacterium; autism; ASD; gut microbiota
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MDPI and ACS Style

Ng, Q.X.; Loke, W.; Venkatanarayanan, N.; Lim, D.Y.; Soh, A.Y.S.; Yeo, W.S. A Systematic Review of the Role of Prebiotics and Probiotics in Autism Spectrum Disorders. Medicina 2019, 55, 129.

AMA Style

Ng QX, Loke W, Venkatanarayanan N, Lim DY, Soh AYS, Yeo WS. A Systematic Review of the Role of Prebiotics and Probiotics in Autism Spectrum Disorders. Medicina. 2019; 55(5):129.

Chicago/Turabian Style

Ng, Qin X.; Loke, Wayren; Venkatanarayanan, Nandini; Lim, Donovan Y.; Soh, Alex Y.S.; Yeo, Wee S. 2019. "A Systematic Review of the Role of Prebiotics and Probiotics in Autism Spectrum Disorders" Medicina 55, no. 5: 129.

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