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Article

GC-MS Chemical Characterization and In Vitro Evaluation of Antioxidant and Toxic Effects Using Drosophila melanogaster Model of the Essential Oil of Lantana montevidensis (Spreng) Briq.

1
Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry, Regional University of Cariri—URCA, Crato-Ceará CEP 63105-000, Brazil
2
Center for Biological and Health Sciences-CCBS, Department of Biological Chemistry Sciences, Regional University of Cariri—URCA, Pimenta, Crato-Ceará CEP 63105-000, Brazil
3
Laboratory of Phytochemistry, Department of Industrial Pharmacy, Federal University of Santa Maria, Santa Maria RS 97105-900, Brazil
*
Authors to whom correspondence should be addressed.
Received: 14 March 2019 / Revised: 27 March 2019 / Accepted: 15 May 2019 / Published: 23 May 2019
(This article belongs to the Special Issue Complementary and Integrative Medicine)
Background and objectives: Natural products such as essential oils with antioxidant potential can reduce the level of oxidative stress and prevent the oxidation of biomolecules. In the present study, we investigated the antioxidant potential of Lantana montevidensis leaf essential oil (EOLM) in chemical and biological models using Drosophila melanogaster. Materials and methods: in addition, the chemical components of the oil were identified and quantified by gas chromatography coupled to mass spectrometry (GC-MS), and the percentage compositions were obtained from electronic integration measurements using flame ionization detection (FID). Results: our results demonstrated that EOLM is rich in terpenes with Germacrene-D (31.27%) and β-caryophyllene (28.15%) as the major components. EOLM (0.12–0.48 g/mL) was ineffective in scavenging DPPH radical, and chelating Fe(II), but showed reducing activity at 0.24 g/mL and 0.48 g/mL. In in vivo studies, exposure of D. melanogaster to EOLM (0.12–0.48 g/mL) for 5 h resulted in 10% mortality; no change in oxidative stress parameters such as total thiol, non-protein thiol, and malondialdehyde contents, in comparison to control (p > 0.05). Conclusions: taken together, our results indicate EOLM may not be toxic at the concentrations tested, and thus may not be suitable for the development of new botanical insecticides, such as fumigants or spray-type control agents against Drosophila melanogaster. View Full-Text
Keywords: Lantana montevidensi; antioxidant activity; fumigant; Drosophila melanogaster; biological activity Lantana montevidensi; antioxidant activity; fumigant; Drosophila melanogaster; biological activity
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MDPI and ACS Style

de Oliveira, M.R.C.; Barros, L.M.; Duarte, A.E.; Gabriely de Lima Silva, M.; da Silva, B.A.F.; Oliveira Brito Pereira Bezerra, A.; Oliveira Tintino, C.D.M.; Afonso Pereira de Oliveira, V.; Boligon, A.A.; Kamdem, J.P.; Coutinho, H.D.M.; de Menezes, I.R.A. GC-MS Chemical Characterization and In Vitro Evaluation of Antioxidant and Toxic Effects Using Drosophila melanogaster Model of the Essential Oil of Lantana montevidensis (Spreng) Briq. Medicina 2019, 55, 194. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina55050194

AMA Style

de Oliveira MRC, Barros LM, Duarte AE, Gabriely de Lima Silva M, da Silva BAF, Oliveira Brito Pereira Bezerra A, Oliveira Tintino CDM, Afonso Pereira de Oliveira V, Boligon AA, Kamdem JP, Coutinho HDM, de Menezes IRA. GC-MS Chemical Characterization and In Vitro Evaluation of Antioxidant and Toxic Effects Using Drosophila melanogaster Model of the Essential Oil of Lantana montevidensis (Spreng) Briq. Medicina. 2019; 55(5):194. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina55050194

Chicago/Turabian Style

de Oliveira, Maria R.C.; Barros, Luiz M.; Duarte, Antônia E.; Gabriely de Lima Silva, Maria; da Silva, Bruno A.F.; Oliveira Brito Pereira Bezerra, Anita; Oliveira Tintino, Cícera D.M.; Afonso Pereira de Oliveira, Victor; Boligon, Aline A.; Kamdem, Jean P.; Coutinho, Henrique D.M.; de Menezes, Irwin R.A. 2019. "GC-MS Chemical Characterization and In Vitro Evaluation of Antioxidant and Toxic Effects Using Drosophila melanogaster Model of the Essential Oil of Lantana montevidensis (Spreng) Briq." Medicina 55, no. 5: 194. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina55050194

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