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Article

Serum Levels of Carbamylated LDL and Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated with Coronary Artery Disease in Patients with Metabolic Syndrome

1
Department of Biochemistry, Faculty of Pharmacy, Medical University—Plovdiv, 4002 Plovdiv, Bulgaria
2
Clinic of Endocrinology and Metabolic Disorders, University Hospital “Kaspela”, 4001 Plovdiv, Bulgaria
*
Author to whom correspondence should be addressed.
Received: 1 July 2019 / Revised: 11 August 2019 / Accepted: 13 August 2019 / Published: 15 August 2019
Background and objectives: Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) has been recognized as the primary receptor for carbamylated low-density lipoproteins (cLDL) and is increasingly being viewed as a critical mediator of vascular inflammation and atherosclerosis. The aim of the current study was to evaluate the possible role of circulating cLDL and soluble LOX-1 (sLOX-1) as potential biomarkers of metabolic syndrome (MetS) as well as of coronary artery disease (CAD) among MetS patients. Materials and Methods: The serum levels of cLDL and sLOX-1 were measured by ELISA in 30 MetS patients without CAD, 30 MetS patients with CAD, and 30 healthy controls. Results: Patients with MetS had significantly higher serum levels of both cLDL and sLOX-1 than the healthy controls but lower in comparison to MetS + CAD subjects. Serum sLOX-1 concentration correlated significantly with fasting glucose (rs = 0.414, p = 0.001) and high-density lipoprotein (HDL)-cholesterol (rs = −0.273, p = 0.035) in the whole MetS cohort, whereas it correlated with cLDL only in the MetS + CAD subgroup (rs = 0.396, p = 0.030). The receiver-operating characteristic (ROC) curves of cLDL and sLOX-1 for MetS diagnosis had area under the curve (AUC) values of 0.761 and 0.692, respectively. AUC values of cLDL and sLOX-1 for CAD diagnosis among MetS patients were 0.811 and 0.739. Elevated serum levels of cLDL and sLOX-1 were associated with a higher risk of MetS development [odds ratio (OR) 24.28, 95% confidence interval (CI): 5.86–104.61, p < 0.001 and OR 4.75; 95% CI: 1.58–14.25, p = 0.009] as well as with presence of CAD among MetS subjects (OR 11.23; 95% CI: 3.10–40.71, p < 0.001 and OR 4.03; 95% CI: 1.73–11.84, p = 0.019, respectively). Conclusions: The present study underscores the potential of cLDL and sLOX-1 as promising biomarkers for diagnosis and risk assessment of MetS and CAD among the MetS population. View Full-Text
Keywords: carbamylated LDL; soluble lectin-like oxidized LDL receptor-1 (LOX-1); metabolic syndrome; coronary artery disease; serum biomarkers; lipoprotein modifications carbamylated LDL; soluble lectin-like oxidized LDL receptor-1 (LOX-1); metabolic syndrome; coronary artery disease; serum biomarkers; lipoprotein modifications
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MDPI and ACS Style

Stankova, T.; Delcheva, G.; Maneva, A.; Vladeva, S. Serum Levels of Carbamylated LDL and Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated with Coronary Artery Disease in Patients with Metabolic Syndrome. Medicina 2019, 55, 493. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina55080493

AMA Style

Stankova T, Delcheva G, Maneva A, Vladeva S. Serum Levels of Carbamylated LDL and Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated with Coronary Artery Disease in Patients with Metabolic Syndrome. Medicina. 2019; 55(8):493. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina55080493

Chicago/Turabian Style

Stankova, Teodora, Ginka Delcheva, Ana Maneva, and Stefka Vladeva. 2019. "Serum Levels of Carbamylated LDL and Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated with Coronary Artery Disease in Patients with Metabolic Syndrome" Medicina 55, no. 8: 493. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina55080493

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