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Prevalence, Epidemiological Characteristics, and Pharmacotherapy of Coronary Artery Disease among Patients with Atrial Fibrillation: Data from Jo-Fib Study

1
Division of Cardiology, Department of Internal Medicine, Jordan University Hospital, University of Jordan School of Medicine, Amman 11942, Jordan
2
University of Jordan School of Medicine, Amman 11942, Jordan
3
Department of neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA
4
Department of Cardiology, Istishari Hospital, Amman 11184, Jordan
*
Author to whom correspondence should be addressed.
Academic Editor: Fabio Angeli
Received: 21 May 2021 / Revised: 31 May 2021 / Accepted: 8 June 2021 / Published: 11 June 2021
(This article belongs to the Section Cardiology)
Background and Objectives: Patients with AF are at increased risk for Coronary Artery Disease (CAD) owing to their shared etiologies and risk factors. This study aimed to assess the prevalence, cardiovascular risk factors, and used medications of CAD in AF patients. Materials and Methods: This retrospective, case-control study utilized data from the Jordanian Atrial Fibrillation (Jo-Fib) registry. Investigators collected clinical features, history of co-existing comorbidities, CHA2DS2-VASc, and HAS BLED scores for all AF patients aged >18 visiting 19 hospitals and 30 outpatient cardiology clinics. A multivariable binary logistic regression was used to asses for factors associated with higher odds of having CAD. Results: Out of 2000 patients with AF, 227 (11.35%) had CAD. Compared to the rest of the sample, those with CAD had significantly higher prevalence of hypertension (82.38%; p < 0.01), hypercholesterolemia (66.52%, p < 0.01), diabetes (56.83%, p < 0.01), and smoking (18.06%, p = 0.04). Patients with AF and CAD had higher use of anticoagulants/antiplatelet agents combination (p < 0.01) compared to the rest of the sample. Females had lower CAD risk than males (OR = 0.35, 95% CI: 0.24–0.50). AF Patients with dyslipidemia (OR = 2.5, 95% CI: 1.8–3.4), smoking (OR = 1.7, 95% CI: 1.1–2.6), higher CHA2DS2-VASc score (OR = 1.5, 95% CI: 1.4–1.7), and asymptomatic AF (OR = 1.9, 95% CI: 1.3–2.6) had higher risk for CAD. Conclusions: Owing to the increased prevalence of CAD in patients with AF, better control of cardiac risk factors is recommended for this special group. Future studies should investigate such interesting relationships to stratify CAD risk in AF patients. We believe that this study adds valuable information regarding the prevalence, epidemiological characteristics, and pharmacotherapy of CAD in patients with AF. View Full-Text
Keywords: atrial fibrillation; coronary artery disease; Jordan; bleeding risk; thromboembolism atrial fibrillation; coronary artery disease; Jordan; bleeding risk; thromboembolism
MDPI and ACS Style

Al-Makhamreh, H.K.; Al-Sabbagh, M.Q.; Shaban, A.E.; Obiedat, A.F.; Hammoudeh, A.J. Prevalence, Epidemiological Characteristics, and Pharmacotherapy of Coronary Artery Disease among Patients with Atrial Fibrillation: Data from Jo-Fib Study. Medicina 2021, 57, 605. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57060605

AMA Style

Al-Makhamreh HK, Al-Sabbagh MQ, Shaban AE, Obiedat AF, Hammoudeh AJ. Prevalence, Epidemiological Characteristics, and Pharmacotherapy of Coronary Artery Disease among Patients with Atrial Fibrillation: Data from Jo-Fib Study. Medicina. 2021; 57(6):605. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57060605

Chicago/Turabian Style

Al-Makhamreh, Hanna K., Mohammed Q. Al-Sabbagh, Ala’ E. Shaban, Abdelrahman F. Obiedat, and Ayman J. Hammoudeh 2021. "Prevalence, Epidemiological Characteristics, and Pharmacotherapy of Coronary Artery Disease among Patients with Atrial Fibrillation: Data from Jo-Fib Study" Medicina 57, no. 6: 605. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57060605

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