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Review

Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer

1
Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country, P.O. Box 644, 48980 Bilbao, Spain
2
Respiratory Department, Cruces University Hospital, P.O. Box 644, 48903 Barakaldo, Spain
3
Ragon Institute of MGH, MITHarvard and HarvardMIT, Cambridge, MA 02139, USA
4
Harvard Medical School, Boston, MA 02114, USA
5
Clinical Neurosciences Research Laboratories, Health Research Institute of Santiago de Compostela (IDIS), Travesa da Choupana s/n, 15706 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Udo Schumacher
Received: 27 June 2021 / Revised: 7 July 2021 / Accepted: 13 July 2021 / Published: 19 July 2021
(This article belongs to the Special Issue Research on Cancer Biology)
Sphingolipids are both structural molecules that are essential for cell architecture and second messengers that are involved in numerous cell functions. Ceramide is the central hub of sphingolipid metabolism. In addition to being the precursor of complex sphingolipids, ceramides induce cell cycle arrest and promote cell death and inflammation. At least some of the enzymes involved in the regulation of sphingolipid metabolism are altered in carcinogenesis, and some are targets for anticancer drugs. A number of scientific reports have shown how alterations in sphingolipid pools can affect cell proliferation, survival and migration. Determination of sphingolipid levels and the regulation of the enzymes that are implicated in their metabolism is a key factor for developing novel therapeutic strategies or improving conventional therapies. The present review highlights the importance of bioactive sphingolipids and their regulatory enzymes as targets for therapeutic interventions with especial emphasis in carcinogenesis and cancer dissemination. View Full-Text
Keywords: ceramide (Cer); sphingolipids (Sphs); cancer; ceramide 1-phosphate (C1P); shingosine 1-phosphate (S1P); deoxy-sphingolipids; apoptosis; cell proliferation ceramide (Cer); sphingolipids (Sphs); cancer; ceramide 1-phosphate (C1P); shingosine 1-phosphate (S1P); deoxy-sphingolipids; apoptosis; cell proliferation
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MDPI and ACS Style

Gomez-Larrauri, A.; Das Adhikari, U.; Aramburu-Nuñez, M.; Custodia, A.; Ouro, A. Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer. Medicina 2021, 57, 729. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57070729

AMA Style

Gomez-Larrauri A, Das Adhikari U, Aramburu-Nuñez M, Custodia A, Ouro A. Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer. Medicina. 2021; 57(7):729. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57070729

Chicago/Turabian Style

Gomez-Larrauri, Ana, Upasana Das Adhikari, Marta Aramburu-Nuñez, Antía Custodia, and Alberto Ouro. 2021. "Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer" Medicina 57, no. 7: 729. https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57070729

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