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Open AccessArticle

The Alkaloid Ageladine A, Originally Isolated from Marine Sponges, Used for pH-Sensitive Imaging of Transparent Marine Animals

Alfred Wegener Institute for Polar and Marine Research in the Helmholtz Society, Am Handelshafen 12, 27570 Bremerhaven, Germany
Mar. Drugs 2012, 10(1), 223-233; https://0-doi-org.brum.beds.ac.uk/10.3390/md10010223
Received: 7 December 2011 / Revised: 10 January 2012 / Accepted: 10 January 2012 / Published: 19 January 2012
(This article belongs to the Special Issue Bioactive Compound from Marine Sponges)
The brominated pyrrole-imidazole Ageladine A was used for live imaging of the jellyfish (jellies) Nausithoe werneri, the sea anemone Metridium senile and the flatworm Macrostomum lignano. The fluorescence properties of Ageladine A allow for estimation of pH values in tissue and organs in living animals. The results showed that Nausithoe werneri had the most acidic areas in the tentacles and close to the mouth (pH 4–6.5), Metridium senile harbours aggregates of high acidity in the tentacles (pH 5) and in Macrostomum lignano, the rhabdoids, the gonads and areas close to the mouth were the most acidic with values down to pH 5. View Full-Text
Keywords: confocal microscopy; fluorescence; transparent animal; non invasive confocal microscopy; fluorescence; transparent animal; non invasive
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Bickmeyer, U. The Alkaloid Ageladine A, Originally Isolated from Marine Sponges, Used for pH-Sensitive Imaging of Transparent Marine Animals. Mar. Drugs 2012, 10, 223-233.

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