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Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals

Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.

National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Institute of Marine Biology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Eastern Marine Biology Research Center, Fisheries Research Institute, Taitung 961, Taiwan
Author to whom correspondence should be addressed.
Mar. Drugs 2012, 10(5), 987-997;
Received: 28 March 2012 / Revised: 18 April 2012 / Accepted: 24 April 2012 / Published: 27 April 2012
One new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane–type sesterterpenes (38), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported from this genus. Compounds 35 exhibited significant cytotoxicity against DLD-1, HCT-116, T-47D and K562 cancer cell lines. View Full-Text
Keywords: sesterterpenoid; scalarane; sponge; Hippospongia sesterterpenoid; scalarane; sponge; Hippospongia
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MDPI and ACS Style

Chang, Y.-C.; Tseng, S.-W.; Liu, L.-L.; Chou, Y.; Ho, Y.-S.; Lu, M.-C.; Su, J.-H. Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.. Mar. Drugs 2012, 10, 987-997.

AMA Style

Chang Y-C, Tseng S-W, Liu L-L, Chou Y, Ho Y-S, Lu M-C, Su J-H. Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.. Marine Drugs. 2012; 10(5):987-997.

Chicago/Turabian Style

Chang, Yu-Chia, Shang-Wei Tseng, Li-Lian Liu, Yalan Chou, Yuan-Shing Ho, Mei-Chin Lu, and Jui-Hsin Su. 2012. "Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp." Marine Drugs 10, no. 5: 987-997.

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