Mar. Drugs, Volume 19, Issue 2 (February 2021) – 75 articles
Cover Story (view full-size image): Biodiscovery from understudied taxa, such as the rare actinomycetes combined with underexplored environments, such as polar marine ecosystems, holds promise for uncovering novel biosynthetic and chemical diversity. However, with increasingly complex specialised metabolite datasets, methods to prioritize this potential are greatly needed. In this study, NPLinker, a new and publicly available software framework was used to integrate, link, and rank (based on scoring functions) metabolomics (molecular families) and genomics (gene cluster families) datasets. This automated approach enables accelerated and informed comparative metabologenomics and, combined with bioactivity data, demonstrates an exciting step towards an integrated-data era for microbial discovery. View this paper.
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