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Phenolic Compounds Diminish Antibiotic Resistance of Staphylococcus Aureus Clinical Strains

Department of Microbiology and Virology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, ul. Jagiellońska 4, 41-200 Sosnowiec, Poland
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Int. J. Environ. Res. Public Health 2018, 15(10), 2321; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph15102321
Received: 24 September 2018 / Revised: 11 October 2018 / Accepted: 17 October 2018 / Published: 22 October 2018
(This article belongs to the Section Global Health)
There is a growing body of evidence that flavonoids show antibacterial activity against both Gram-positive and Gram-negative bacteria. The mechanisms of action of phenolic compounds on bacterial cell have been partially attributed to damage to the bacterial membrane, inhibition of virulence factors such as enzymes and toxins, and suppression of bacterial biofilm formation. What is more, some natural polyphenols, aside from direct antibacterial activity, exert a synergistic effect when combined with common chemotherapeutics. Many studies have proved that in synergy with antibiotics plant flavonoids pose a promising alternative for therapeutic strategies against drug resistant bacteria. In this review most recent reports on antimicrobial action of polyphenols on Staphylococcus aureus strains are described, highlighting where proven, the mechanisms of action and the structure–activity relationships. Since many reports in this field are, to some extent, conflicting, a unified in vitro and in vivo susceptibility testing algorithms should be introduced to ensure the selection of effective antibacterial polyphenolic compounds with low cytotoxicity and minimal side effects. View Full-Text
Keywords: polyphenols; antibacterial activity; Staphylococcus aureus; antibiotics polyphenols; antibacterial activity; Staphylococcus aureus; antibiotics
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MDPI and ACS Style

Miklasińska-Majdanik, M.; Kępa, M.; Wojtyczka, R.D.; Idzik, D.; Wąsik, T.J. Phenolic Compounds Diminish Antibiotic Resistance of Staphylococcus Aureus Clinical Strains. Int. J. Environ. Res. Public Health 2018, 15, 2321. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph15102321

AMA Style

Miklasińska-Majdanik M, Kępa M, Wojtyczka RD, Idzik D, Wąsik TJ. Phenolic Compounds Diminish Antibiotic Resistance of Staphylococcus Aureus Clinical Strains. International Journal of Environmental Research and Public Health. 2018; 15(10):2321. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph15102321

Chicago/Turabian Style

Miklasińska-Majdanik, Maria, Małgorzata Kępa, Robert D. Wojtyczka, Danuta Idzik, and Tomasz J. Wąsik 2018. "Phenolic Compounds Diminish Antibiotic Resistance of Staphylococcus Aureus Clinical Strains" International Journal of Environmental Research and Public Health 15, no. 10: 2321. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph15102321

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