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Open AccessArticle

Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy

1
INAIL, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Via di Fontana Candida 1, Monteporzio Catone, 00078 Rome, Italy
2
Lazio Regional Health Service, Department of Epidemiology, Via Cristoforo Colombo 112, 00147 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(4), 804; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph15040804
Received: 6 March 2018 / Revised: 13 April 2018 / Accepted: 17 April 2018 / Published: 19 April 2018
(This article belongs to the Special Issue Environmental Tobacco Smoke: Exposure and Effects)
Background: Urinary cotinine, a metabolite of nicotine, is a marker of tobacco smoke exposure. A cutoff value for cotinine concentration can be set to distinguish smokers from non-smokers, independently from self-declared status. Method: Cotinine was determined by isotopic dilution High Performance Liquid Chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) between 2013 and 2014 on urine samples of a population of 1075 subjects. Results: 296 subjects have a cotinine level higher than 100 μg/g of creatinine (cutoff), with a median cotinine concentration of 1504.70 μg/g of creatinine. The mean is 27.5% of smokers and 60.5% in this group are females. The median value for non-smokers is 5.6 μg/g of creatinine. Two hundred and seventy-five subjects declared to be smokers in the questionnaire, but 6 (2.2%) present urinary cotinine levels lower than cutoff; 800 subjects declared to be non-smokers, but 26 of them presented urinary cotinine levels that were higher than the cutoff (3.3%). Conclusion: Using the cutoff of 100 μg/g, the misclassification of smokers resulted to be 2.2%, indicating that the selected value is suitable for studying the human exposures to environmental and occupational pollutants, including those produced by smoking. View Full-Text
Keywords: biomarkers; urinary cotinine; environmental tobacco smoke; smoking; cutoff; HPLC-MS/MS biomarkers; urinary cotinine; environmental tobacco smoke; smoking; cutoff; HPLC-MS/MS
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MDPI and ACS Style

Paci, E.; Pigini, D.; Bauleo, L.; Ancona, C.; Forastiere, F.; Tranfo, G. Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy. Int. J. Environ. Res. Public Health 2018, 15, 804. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph15040804

AMA Style

Paci E, Pigini D, Bauleo L, Ancona C, Forastiere F, Tranfo G. Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy. International Journal of Environmental Research and Public Health. 2018; 15(4):804. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph15040804

Chicago/Turabian Style

Paci, Enrico; Pigini, Daniela; Bauleo, Lisa; Ancona, Carla; Forastiere, Francesco; Tranfo, Giovanna. 2018. "Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy" Int. J. Environ. Res. Public Health 15, no. 4: 804. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph15040804

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