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Article

Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test

1
Department of ‘Organi di Senso’, University “Sapienza”, Viale dell’Università 33, 00161 Rome, Italy
2
Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121 Forlì, Italy
3
Department ENT and Audiology, University of Ferrara, Via Aldo Moro, 8, 44124 Ferrara, Italy
4
Department of Oral and Maxillo Facial Sciences, University “Sapienza”, Via Caserta, 6, 00161 Rome, Italy
5
Department of Cardiovascular, Respiratory, Nephrologic, Anaesthesiologic and Geriatric Sciences, Sapienza University, Viale dell’Università 33, 00161 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(11), 2056; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16112056
Received: 16 April 2019 / Revised: 5 June 2019 / Accepted: 6 June 2019 / Published: 10 June 2019
(This article belongs to the Special Issue Sleep Disorders Across the Lifespan: A Different Perspective)
Background: To investigate the presence of laryngopharyngeal reflux in patients with obstructive sleep apnea (OSA) employing the salivary pepsin concentration method. To compare the results of pepsin concentration with the severity of the pathology. Methods: Seventy-five OSA patients (44 males, 31 females) were enrolled in the study. For each patient, the AHI (apnea–hypopnea index) and the BMI (body mass index) were initially evaluated. All the patients enrolled were assessed using the reflux symptom index (RSI) and the reflux finding score (RFS) in order to perform a clinical diagnosis of laryngopharyngeal reflux. In all patients a salivary sample was taken to estimate the presence of pepsin and its concentration. Results: The incidence of LPR (laryngopharyngeal reflux) in OSA patients, evaluated using the salivary pepsin concentration test (PEP-test), was found to be 32% of cases. Linear regression testing did not show any correlation between AHI and pepsin concentration in salivary samples (p = 0.1). Conclusion: A high number of patients with OSA seem to show positivity for salivary pepsin, correlated to an LPR. There does not appear to be a correlation between the severity of apnea and the grade of salivary pepsin reflux. On the other hand, direct correlation between BMI and the value of pepsin in salivary specimens was observed. View Full-Text
Keywords: laryngopharyngeal reflux; obstructive sleep apnea; Obstructive Sleep Apnea Syndrome; PEP-test laryngopharyngeal reflux; obstructive sleep apnea; Obstructive Sleep Apnea Syndrome; PEP-test
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MDPI and ACS Style

Iannella, G.; Vicini, C.; Polimeni, A.; Greco, A.; Gobbi, R.; Montevecchi, F.; De Vito, A.; Meccariello, G.; Cammaroto, G.; D’Agostino, G.; Pace, A.; Cascella, R.; Brunori, M.; Lo Iacono, C.A.M.; Pelucchi, S.; Magliulo, G. Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test. Int. J. Environ. Res. Public Health 2019, 16, 2056. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16112056

AMA Style

Iannella G, Vicini C, Polimeni A, Greco A, Gobbi R, Montevecchi F, De Vito A, Meccariello G, Cammaroto G, D’Agostino G, Pace A, Cascella R, Brunori M, Lo Iacono CAM, Pelucchi S, Magliulo G. Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test. International Journal of Environmental Research and Public Health. 2019; 16(11):2056. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16112056

Chicago/Turabian Style

Iannella, Giannicola, Claudio Vicini, Antonella Polimeni, Antonio Greco, Riccardo Gobbi, Filippo Montevecchi, Andrea De Vito, Giuseppe Meccariello, Giovanni Cammaroto, Giovanni D’Agostino, Annalisa Pace, Raffaella Cascella, Marco Brunori, Cristina A.M. Lo Iacono, Stefano Pelucchi, and Giuseppe Magliulo. 2019. "Laryngopharyngeal Reflux Diagnosis in Obstructive Sleep Apnea Patients Using the Pepsin Salivary Test" International Journal of Environmental Research and Public Health 16, no. 11: 2056. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16112056

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