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Article

Non-Surgical Treatment of Periodontal Disease in a Pregnant Caucasian Women Population: Adverse Pregnancy Outcomes of a Randomized Clinical Trial

1
Medical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain
2
Department of Obstetrics and Gynecology, Clinic University Hospital of Santiago de Compostela, 15782 Santiago de Compostela, Spain
3
Special Needs Unit, School of Medicine and Dentistry, Santiago de Compostela University, 15782 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(19), 3638; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16193638
Received: 9 August 2019 / Revised: 22 September 2019 / Accepted: 24 September 2019 / Published: 27 September 2019
(This article belongs to the Special Issue Oral Health and Diseases)
Aim: To analyze if non-surgical treatment of periodontitis in a pregnant Caucasian women population can reduce adverse pregnancy outcomes. Methods and results: A parallel randomized clinical trial was designed and approved by the Ethical Committee of Sanitary Area Santiago-Lugo, Spain (registration number: 2016/451). Forty patients with periodontitis stage II grade B were randomly allocated to receive either comprehensive non-surgical periodontal therapy (test group; n = 20) or professional tooth cleaning (control group; n = 20) before 24 gestational weeks. Randomization was computer-generated by the statistic program Epidat v.4.1 and allocation was performed using sealed opaque envelopes. Clinical measurements and peripheral blood samples for biochemical variables were collected at baseline, in the middle of second trimester before non-surgical treatment, and in the third trimester. Microbiological samples were collected in the second and third trimester. A statistically significant reduction was verified in all clinical and microbiological parameters after periodontal treatment in the test group. No significant differences were observed for the rest of the variables, including preterm birth and/or low birth weight. No adverse events related to periodontal treatment were reported. Conclusions: Non-surgical periodontal treatment in Caucasian patients with periodontitis stage II grade B did not significantly reduce the risk of adverse pregnancy outcomes. View Full-Text
Keywords: preterm birth; low birth weight; pregnancy; periodontal disease preterm birth; low birth weight; pregnancy; periodontal disease
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MDPI and ACS Style

Caneiro-Queija, L.; López-Carral, J.; Martin-Lancharro, P.; Limeres-Posse, J.; Diz-Dios, P.; Blanco-Carrion, J. Non-Surgical Treatment of Periodontal Disease in a Pregnant Caucasian Women Population: Adverse Pregnancy Outcomes of a Randomized Clinical Trial. Int. J. Environ. Res. Public Health 2019, 16, 3638. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16193638

AMA Style

Caneiro-Queija L, López-Carral J, Martin-Lancharro P, Limeres-Posse J, Diz-Dios P, Blanco-Carrion J. Non-Surgical Treatment of Periodontal Disease in a Pregnant Caucasian Women Population: Adverse Pregnancy Outcomes of a Randomized Clinical Trial. International Journal of Environmental Research and Public Health. 2019; 16(19):3638. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16193638

Chicago/Turabian Style

Caneiro-Queija, Leticia, Jose López-Carral, Pablo Martin-Lancharro, Jacobo Limeres-Posse, Pedro Diz-Dios, and Juan Blanco-Carrion. 2019. "Non-Surgical Treatment of Periodontal Disease in a Pregnant Caucasian Women Population: Adverse Pregnancy Outcomes of a Randomized Clinical Trial" International Journal of Environmental Research and Public Health 16, no. 19: 3638. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph16193638

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